Cell Signaling News and Research

RSS

Cell signaling is vital for cells to communicate and coordinate their activities, not just in the human body, but in all organisms. There are thousands of signaling pathways, ranging from protein homeostasis to carcinogenesis and biofilm formation.

Ex Vivo Expansion of HSCs Using a Novel Culture System

Hematopoietic stem cells (HSCs) are immature blood cells found in the bone marrow that can be stimulated to develop into any type of blood cell.

25 May 2023

From Clocks to Cells: Unleashing the Potential of Dual Oscillatory Signaling

Christian Huygens recorded his observations of the synchronization of two pendulum clocks in 1665. It takes precise quantitative control to properly regulate oscillatory dynamics, which are seen in essential biological processes including circadian clocks, segmentation, and transcription factor responses in addition to physical systems.

22 May 2023

Understanding How Cell-to-Cell Communication Networks Drive Pancreatic Cancer Development

Discussions of cancer often stress the genetic mutations that drive disease by altering the normal function of cellular proteins.

12 May 2023

Senescent Cells Use Cell-Cell Communication to Influence Regeneration in Salamanders

Senescent cells are cells that have permanently stopped dividing in response to cellular stress but have not died.

17 Apr 2023

Determining the structure of protein pumps using cryo-EM

A rare, genetic disorder known as Hailey-Hailey disease causes patches of blisters to develop mainly in the folds of skin under the breasts, in the groin, and the armpits.

29 Mar 2023

Identifying the underlying causes of rare genetic immune disorders

The activated PI3K Delta syndrome 2 (APDS2) is a rare genetic disease that is caused by cellular anomalies, according to experts from the Garvan Institute of Medical Research.

23 Mar 2023

First molecular images of olfaction sets the stage to create novel smells

Breaking a longstanding impasse in our understanding of olfaction, scientists at UC San Francisco (UCSF) have created the first molecular-level, 3D picture of how an odor molecule activates a human odorant receptor, a crucial step in deciphering the sense of smell.

16 Mar 2023

New optical tool controls bacterial electrical signaling

Bacteria, like neurons in human brains, utilize electricity to interact and react to environmental cues. Scientists have now developed a strategy to regulate this electrical signaling in bacteria to better comprehend antibiotic resistance.

From The University of Warwick 15 Feb 2023

3D structure of a major protein complex in cilia revealed

Researchers at St. Jude Children’s Research Hospital have solved the 3D structure of an important protein complex in cilia, which are signaling appendages found on cells. The structure was pictured at the highest resolution available at the time.

15 Feb 2023

Grasping how a biological pathway causes stem cells to regenerate or die

According to a recent study conducted by Cedars-Sinai and the University of California, San Francisco (UCSF), altering a cellular process can cause stem cells, which are the cells that give rise to all other types of body cells, to either die or regenerate.

18 Jan 2023

Innovative strategy for studying membrane proteins

Membrane proteins are vital therapeutic targets. They exist between the interior and exterior of human cells. Some of them, known as “transporters,” transport substances into and out of the cellular environment.

26 Oct 2022

Characterizing the transcription profile of microglia in a mouse model

Researchers from Tohoku University have now shown that the consolidation and extinction of contextual fear conditioning alter the microglial genes connected to the synapse—structures that permit neurons to communicate with one another.

13 Sep 2022

Research reveals that pain-blocking neurotransmitters offer long-term relief in mice

An international team of researchers found that a gene therapy that prevents targeted nerve cell signaling substantially lower neuropathic pain with no detectable side effects.

From UC San Diego 12 May 2022

Microcolonies in the GI tract comprise an important niche for cell-cell signaling and plasmid transfer

Published in Nature Communications, research from the University of Minnesota and Mayo Clinic sought to understand how microbial communities help people resist pathogens.

11 Apr 2022

Powerhouse-pruning protein may be a sound target to help trigger new blood vessel growth

A protein that helps keep our cell powerhouses working at a premium appears to also help make energy rapidly available when it's time to make new blood vessels.

5 Apr 2022

Study helps to make sense of cell-to-cell variation in response to external stimuli

Why do genetically similar cells react to the same extrinsic stimuli, such as antibiotics, in such diverse ways?

1 Apr 2022

Unusual partners aid new blood vessel development

Insufficient oxygen to an area like the heart or legs, called hypoxia, is a cue to our bodies to make more blood vessels, and scientists have found some unusual partners are key to making that happen.

9 Mar 2022

Researchers gain better understanding of the fast signaling dynamics in stem cells

Divide, differentiate or die? Making decisions at the right time and place is what defines a cell's behavior and is particularly critical for stem cells of an developing organisms.

From The Max Planck Institute 25 Feb 2022

Central signaling pathway likely to help reduce the progression of autoimmune disorders

When the immune system fails and assaults the body’s own components, autoimmune disorders develop.

25 Feb 2022

Researchers identify protein switch that regulates enzymes in pathogens

Proteins are the “workhorses” of all living cells and are the chemical foundation of life.

22 Feb 2022