Cytokine is a substance that is made by cells of the immune system. Some cytokines can boost the immune response and others can suppress it. Cytokines can also be made in the laboratory by recombinant DNA technology and used in the treatment of various diseases, including cancer.
Researchers from Nagoya University’s Graduate School of Medicine in Japan have uncovered how microRNA (miRNA) affects inflammation in mice with lupus. They discovered two downregulated miRNAs in the disease along with a rare circumstance where several miRNAs control the same set of genes.
An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including life-threatening fungal pneumonia.
Trinity researchers have made a significant advance in understanding how inflammation is controlled. They recently discovered that a crucial immunological alarm protein that was previously thought to quiet the immune response apparently performs the opposite.
In two distinct studies, scientists show how synthetic biology can be used to address a challenging problem in cancer immunotherapy: the way immunotherapy-related approaches focused on the short-term killing of tumor cells could fail to eradicate tumors because tumor growth occurs on longer timescales.
Gyros Protein Technologies AB today introduced Gyrolab® Human Cytokine Kit Reagents, the first in a range of new biomarker kits.
Mitochondria are highly regarded as the cell's powerhouse. However, these cellular organelles are essential for more than only energy production: Professor Konstanze Winklhofer and her colleagues at Ruhr University Bochum’s Faculty of Medicine have found that mitochondria play an essential role in signal transduction in innate immune pathways.
After analyzing data from a public repository, CD4-T, CD8-T cells, and Treg cells, a team of researchers led by bioinformatics Mabel Vidal from the University of Concepcion and working with researchers from MELISA Institute and other academic institutions discovered a distinctive genetic signature among subsets of infiltrating T cells of various types of cancer.
Researchers from Tohoku University have now shown that the consolidation and extinction of contextual fear conditioning alter the microglial genes connected to the synapse—structures that permit neurons to communicate with one another.
The University of Texas MD Anderson Cancer Center and Virogin Biotech today announced a strategic collaboration to accelerate the development of investigational treatments, including oncolytic viruses and immunotherapies, for patients with advanced cancers.
Mitochondria are self-contained organelles that reside inside cells and are tasked with producing the chemical energy required to power vital tasks necessary for life and wellbeing. They have their own mini-chromosome and DNA.
A new study performed has offered better knowledge about how genetic factors tend to impact the immune response of the body in type 1 diabetes.
G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved drugs, are being studied by scientists at St. Jude Children’s Research Hospital and Columbia University/New York State Psychiatric Institute.
A new study reports that immune cell responses to bacteria affect the intrinsic excitability of rat neuronal subtypes differently.
A team of researchers at Sweden’s Karolinska Institutet studied how specific immune cells known as innate lymphoid cells (ILCs), which play a role in inflammatory bowel disease (IBD), evolve into mature cells.
Researchers have identified a family of proteins that is significantly elevated in the saliva of patients hospitalized with COVID-19.
Sepsis is a high-mortality disease that arises when the body's immune reaction to pathogens causes multi-organ defects.
Researchers at the La Jolla Institute for Immunology have uncovered novel genes associated with the risk of autoimmune disorders in the CD4+ “helper” T cell subset.
According to a recent preclinical study from Weill Cornell Medicine, a certain species of fungus found in the intestines can protect against intestinal damage.
A one-time infusion of stem cells from bone marrow improves the survival of mice with sepsis, shows a study published today in eLife.
Humans and their pathogens interact in a complex way, resulting in disease and health.