DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.
According to findings published in eLife, genetics may contribute to the explanation of the connection between unhealthy lifestyles and increased biological aging in young adults.
Strict parenting can influence how the body reads the children’s DNA. These modifications can become “hard-wired” into the DNA of kids who consider their parents to be harsh, enhancing their biological risk for depression in adolescence and later life.
The Babraham Institute’s Reik lab’s study has improved the understanding of the function of DNA methylation during the early stages of development.
DNA analysis and a collection of photographs of genetically unrelated lookalikes have shown that strong facial likeness is tied to shared genetic variations. The article is published in Cell Reports on August 23rd, 2022.
Research reported that the DMDRMR/miR-378a-5p/ DAB2IP axis enhances angiogenesis and sunitinib resistance, suggesting that it could be used for patients with ccRCC.
DNA methylation is a critical epigenetic alteration for mammalian development.
Jerry Guintivano, PhD, of the University of North Carolina School of Medicine, led an exclusive transcriptome-wide association research that showed substantial changes in B-cells in women with postpartum depression, with pathway observations indicating modified B-cell activation and insulin resistance.
A new study headed by ISGlobal, an organization financed by “Ia Caixa” Foundation, finds links between DNA methylation patterns and gene expression levels in blood samples from youngsters.
In the current study, scientists at Baylor College of Medicine identified that the cells of humans and animals that recovered from tuberculosis had prematurely aged up to 12 to 14 years.
Citrus is a significant and economically beneficial horticultural crop with nucellar polyembryony, which prevents hybrid offspring from being produced. Citrus is produced mostly through asexual methods like grafting and cuttings.
A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.
A new study led by University of Liverpool reserchers has shown that the effects of pollutants can be transmitted over many generations in water fleas and may persist long enough to influence the evolutionary process.
Flow cytometry is a powerful and complex technology used to count, sort or measure characteristics of cells and to detect biomarkers.
For people who hate exercising, here comes some more bad news: it may also keep you younger. Not just looking younger, but actually younger, on an epigenetic level.
Researchers at Columbia University Mailman School of Public Health have developed a new blood test to measure the pace of biological aging. Based on an analysis of chemical tags on the DNA contained in white blood cells, called DNA methylation marks, the new test is named DunedinPACE, after the Dunedin Birth Cohort used to develop it.
Hereditary diseases, along with cancers and cardiovascular diseases, may be linked to genomic imprinting.
According to researchers at Salk, the CLASSY gene family controls which portions of the genome are turned off in a tissue-specific manner.
A folic acid-like drug, L-methylfolate, when administered alongside the standard therapy for patients with recurrent glioblastoma, changed aDNA process within their brain tumors, according to results from a phase 1 clinical trial.
The human immune system works hard to maintain an individual’s health and protect against viruses, bacteria, parasites, fungi, and cancerous cells.
The advancements in technology might come up with techniques that measure biological parameters in real-time in living organisms, which can help monitor tissue homeostasis, on the go. A significant component of such homeostasis is tissue oxygen concentration.