DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.
A higher risk of reproductive and child health issues is linked to advanced paternal age. Increasing evidence points to age-related alterations in the sperm epigenome as one underlying cause.
Experts from the University of Barcelona, the Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), the Institute of Microelectronics of Barcelona (IMB-CNM-CSIC) and the Aragon Nanoscience and Materials Institute of Aragon (INMA) -;a joint institute of the CSIC and the University of Zaragoza-; have developed a new method to detect RNA viruses based on the triplex-forming probe technology.
To share nutrients and enhance their capacity for environmental adaptability, tree roots frequently collaborate with fungi. Although this interaction is mutually beneficial (namely, ectomycorrhizae), the biological mechanisms at play have not yet been completely analyzed.
Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).
If the genome is viewed as a guidebook for how a cell should operate, then annotations, highlights, and bookmarks are included on every page.
The January 2023 issue of SLAS Discovery contains a collection of four full-length articles and one technical brief covering cancer research, high-throughput screening (HTS) assay development and other drug discovery exploration.
Twenty years ago, following the initial sequencing of the human genome, geneticists started carrying out extensive genome-wide association studies to find genomic regions connected to human disease.
As seasoned gardeners know, broccoli heads don't develop properly and can resemble cauliflower when grown in higher temperatures.
For the first time, researchers at the University of Helsinki in Finland examined the effects of prenatal alcohol exposure on the epigenome and gene function of the placenta. The epigenome is a molecular coating on a DNA strand that controls how genes are expressed.
According to findings published in eLife, genetics may contribute to the explanation of the connection between unhealthy lifestyles and increased biological aging in young adults.
Strict parenting can influence how the body reads the children’s DNA. These modifications can become “hard-wired” into the DNA of kids who consider their parents to be harsh, enhancing their biological risk for depression in adolescence and later life.
The Babraham Institute’s Reik lab’s study has improved the understanding of the function of DNA methylation during the early stages of development.
DNA analysis and a collection of photographs of genetically unrelated lookalikes have shown that strong facial likeness is tied to shared genetic variations. The article is published in Cell Reports on August 23rd, 2022.
Research reported that the DMDRMR/miR-378a-5p/ DAB2IP axis enhances angiogenesis and sunitinib resistance, suggesting that it could be used for patients with ccRCC.
DNA methylation is a critical epigenetic alteration for mammalian development.
Jerry Guintivano, PhD, of the University of North Carolina School of Medicine, led an exclusive transcriptome-wide association research that showed substantial changes in B-cells in women with postpartum depression, with pathway observations indicating modified B-cell activation and insulin resistance.
A new study headed by ISGlobal, an organization financed by “Ia Caixa” Foundation, finds links between DNA methylation patterns and gene expression levels in blood samples from youngsters.
In the current study, scientists at Baylor College of Medicine identified that the cells of humans and animals that recovered from tuberculosis had prematurely aged up to 12 to 14 years.
Citrus is a significant and economically beneficial horticultural crop with nucellar polyembryony, which prevents hybrid offspring from being produced. Citrus is produced mostly through asexual methods like grafting and cuttings.
A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.