Dementia News and Research

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Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations.

Neuronal and glial circuits form loosely coupled super-network within the brain

Tohoku University scientists have shown that neuronal and glial circuits form a loosely coupled super-network within the brain.

25 Feb 2021

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

From UC San Diego 19 Feb 2021

Ancestral backgrounds can influence Alzheimer's disease risk, finds study

Genetics contributes to the risk of developing Alzheimer's disease, and the APOE gene is the strongest genetic risk factor, specifically the APOE4 allele.

5 Feb 2021

TBI: Increased levels of immune cells promote inflammation that may worsen brain damage

Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report.

27 Jan 2021

Researchers discover genetic risk factor for stroke

A research team from Geisinger Health System has detected a common genetic variant as a risk factor for stroke, particularly in patients aged more than 65.

20 Jan 2021

Study shows how AFV3-109 protein with slipknot structure folds and unfolds based on temperature

Scientists from the Pacific Quantum Center of Far Eastern Federal University (FEFU) figured out how the AFV3-109 protein with slipknot structure folds and unfolds depending on temperature. The protein is typical for the viruses of the oldest single-celled organisms that can survive in the extreme conditions of underwater volcanic sources - archaea. The research outcome appears in PLOS ONE.

15 Jan 2021

KAIST researchers identify mechanism underlying plasticity in adult brains

Developing brains constantly sprout new neuronal connections called synapses as they learn and remember. Important connections — the ones that are repeatedly introduced, such as how to avoid danger — are nurtured and reinforced, while connections deemed unnecessary are pruned away.

28 Dec 2020

Anti-diarrhea drug could be used to induce cell death in glioblastoma cell lines

The research group led by Dr Sjoerd van Wijk from the Institute of Experimental Cancer Research in Paediatrics at Goethe University already two years ago found evidence indicating that the anti-diarrhea drug loperamide could be used to induce cell death in glioblastoma cell lines.

23 Dec 2020

New model shows how the brain uses "gating" phenomenon to control information

Getting computers to "think" like humans is the holy grail of artificial intelligence, but human brains turn out to be tough acts to follow. T

17 Dec 2020

Study examines impacts of widespread ocean pollution on human health

Ocean pollution is widespread and getting worse, and when toxins in the oceans make landfall they imperil the health and well-being of more than 3 billion people, according to a new report by an international coalition of scientists led by Boston College's Global Observatory on Pollution on Health and the Centre Scientifique de Monaco, supported by the Prince Albert II of Monaco Foundation.

4 Dec 2020

Researchers identify promising treatments for late-onset Alzheimer’s disease

Scientists from The Mount Sinai Hospital and the National Center for Geriatrics and Gerontology based in Japan have recently discovered novel molecular mechanisms that drive late-onset Alzheimer’s disease (LOAD).

25 Nov 2020

Tau protein in Alzheimer's disease looks different at every dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes to propagating the disease in the brain.

19 Nov 2020

Study shows how air pollution exposures affect mental health later in life

In a study of women aged 80 years and older, living in locations with higher exposures to air pollution was associated with increased depressive symptoms.

19 Nov 2020

Study confirms correlation between gut microbiota and Alzheimer's disease

Alzheimer's disease is the most common cause of dementia. Still incurable, it directly affects nearly one million people in Europe, and indirectly millions of family members as well as society as a whole.

16 Nov 2020

Researcher develops procedures for defining preclinical stages of Alzheimer's disease

Both of Andrew Kiselica's grandfathers developed dementia when he was in graduate school. As Kiselica was going through neuropsychology training in graduate school, he saw his mother's father become unable to walk or speak due to severe dementia.

12 Nov 2020

Genetically edited form of herpes simplex virus outperforms key vaccine candidate

A genetically edited form of a herpes simplex virus -- rewired to keep it from taking refuge in the nervous system and eluding an immune response -- has outperformed a leading vaccine candidate in a new study from the University of Cincinnati, Northwestern University and the University of Nebraska-Lincoln.

9 Nov 2020

Dementia News and Research

Neuronal and glial circuits form loosely coupled super-network within the brain

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Ancestral backgrounds can influence Alzheimer's disease risk, finds study

TBI: Increased levels of immune cells promote inflammation that may worsen brain damage

Researchers discover genetic risk factor for stroke

Study shows how AFV3-109 protein with slipknot structure folds and unfolds based on temperature

KAIST researchers identify mechanism underlying plasticity in adult brains

Anti-diarrhea drug could be used to induce cell death in glioblastoma cell lines

New model shows how the brain uses "gating" phenomenon to control information

Study examines impacts of widespread ocean pollution on human health

Researchers identify promising treatments for late-onset Alzheimer’s disease

Tau protein in Alzheimer's disease looks different at every dementia stage

Study shows how air pollution exposures affect mental health later in life

Study confirms correlation between gut microbiota and Alzheimer's disease

Researcher develops procedures for defining preclinical stages of Alzheimer's disease

Genetically edited form of herpes simplex virus outperforms key vaccine candidate

LipiDiDiet project shows positive effects of nutrient intervention in early Alzheimer’s disease

Beetroot peptide may help treat inflammatory, neurodegenerative diseases

Study shows statins have different effects on different parts of the body

SARS-Cov-2 spike proteins can directly impact the function of blood-brain barrier

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