Dementia is not a specific disease. It is a descriptive term for a collection of symptoms that can be caused by a number of disorders that affect the brain. People with dementia have significantly impaired intellectual functioning that interferes with normal activities and relationships. They also lose their ability to solve problems and maintain emotional control, and they may experience personality changes and behavioral problems, such as agitation, delusions, and hallucinations.
The research, headed by Professor Michael Schrader of the University of Exeter, looked at peroxisome dynamics and discovered new ways for them to divide.
Researchers employed gene editing to switch off a specific component in the tomato plant’s DNA, which led to an increase in provitamin D3 in both the fruit and leaves. After that, UVB light was used to convert it to vitamin D3.
Amyloidosis is a term used to describe a group of diseases defined by the formation of insoluble proteins called amyloids outside of cells as a result of misfolding and aggregation of soluble proteins.
Recently, researchers have discovered a novel method that could help avoid the formation of protein tangles, which are typical in dementia.
Scientists have known for years that amyloid fibrils -; fibrous, ropelike structures formed by closely linked protein molecules -; are present in the brains of patients with Alzheimer's and Parkinson's diseases and likely play a role in the progression of these disorders.
The loss of functional neurons in the brain is a characteristic of Alzheimer’s disease. What, on the other hand, is the source of this loss?
For World Creativity and Innovation Day, we asked leading experts within the life sciences industry 'What does creativity and innovation look like to you within science?'.
According to the Alzheimer’s Association, around 11% of the population, comprising 65-year old and above—in the United States has been diagnosed with Alzheimer’s disease (AD), the most prevalent form of dementia that causes memory loss and cognitive impairment.
According to Weill Cornell Medicine researchers, inhibiting a critical signaling route in brain-resident immune cells may reduce brain inflammation and hence halt the progression of the disease in Alzheimer’s and other neurodegenerative disorders.
A recently discovered chemical compound helped elderly mice with obesity lose fat and weight, add muscle and strength, reduce age-related inflammation and increase physical activity, a new study shows.
If we want to enhance our knowledge and treatment of Alzheimer’s disease, we need to identify genetic risk factors.
Upon examining the gene activity in dog brain tissues, it was revealed that a major part is active in every animal.
An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.
In a study led by Cedars-Sinai, researchers have discovered two types of brain cells that play a key role in dividing continuous human experience into distinct segments that can be recalled later.
Take a cell-deep tour of a brain afflicted with Alzheimer's disease, and you will find minuscule clumps of protein that seem suspicious. Ever since the 1980s, when neuroscientists began identifying these protein tangles, researchers have discovered that other brain diseases have their own tangled-protein signatures.
Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia.
Parkinson's disease may be driven in part by cell stress-related biochemical events that disrupt a key cellular cleanup system, leading to the spread of harmful protein aggregates in the brain, according to a new study from scientists at Scripps Research.
Recent research discovered common genetic factors between depression and AD.
While the word "mutation" may conjure up alarming notions, a mutation in brain immune cells serves a positive role in protecting people against Alzheimer's disease.
An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.