Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Teixobactin-based drug can kill superbugs

A team of researchers has reached one step closer in its quest for developing a feasible teixobactin-based drug.

8 Jun 2020

UCL scientists discover genes responsible for maintaining healthy hearing

Scientists at UCL have discovered sets of regulatory genes, which are responsible for maintaining healthy hearing. The finding, made in fruit flies, could potentially lead to treatments for age-related hearing loss (ARHL) in humans.

From University College London 3 Jun 2020

Research project launched to find new treatments for rare genetic diseases

The University Carlos III Madrid, Almirall, S.A. and the MEDINA Foundation have launched a project to find new treatments for recessive dystrophic epidermolysis bullosa and other genetic diseases caused by nonsense mutations.

29 May 2020

Innovative tool to speed up the drug discovery process

A better understanding of the interaction between a molecule and the organism is important to consider its therapeutic potential.

21 May 2020

X-ray experiments reveal antibody to block entry of SARS-CoV-2

As scientists across the globe race to develop a vaccine against SARS-CoV-2, the coronavirus that causes COVID-19, an international team led by Davide Corti at Vir Biotechnology and David Veesler at the University of Washington has been working around the clock on a complementary approach - identifying neutralizing antibodies that could be used as a preventative treatment or as a post-exposure therapy.

20 May 2020

The Global Hunt To Block COVID-19

A molecular biologist is working with a world leader in artificial intelligence-based drug discovery to help find a molecule that could prevent SARS-CoV-2.

19 May 2020

Study reveals nuanced role for oncogene in contact inhibition

Like subway com muters on a crowded train, cells generally prefer not to be packed in too tightly. In fact, they have set up mechanisms to avoid this, a phenomenon called "contact inhibition."

15 May 2020

Researchers identify missing component of innate immune signaling

How cells recognize pathogens and alert the immune system swiftly is a fundamental process of high importance for the survival of any species, including humans.

14 May 2020

Evidence of the ‘metabolon’

AZoLifeSciences speaks to Dr. Vidhi Pateek about her teams research that led to discovering evidence of the metabolon's existence.

From Penn State University 14 May 2020

New breakthrough could accelerate drug development

Scientists have successfully developed a new technique to reliably grow crystals of organic soluble molecules from nanoscale droplets, unlocking the potential of accelerated new drug development.

From Newcastle University 11 May 2020

Project Expands Use Of Metal Catalysts For Drug Discovery

The use of metals in drug delivery could offer major benefits, including allowing for lower dosages of a medication to achieve therapeutic effects.

7 May 2020

AI accelerates drug discovery to fight COVID-19

A global race is underway to discover a vaccine, drug, or combination of treatments that can disrupt the SARS-CoV-2 virus, which causes the COVID-19 disease, and prevent widespread deaths.

24 Apr 2020

Scientists elucidate precise shape of a key player in human metabolism

A USC-led international team of scientists has found the precise shape of a key player in human metabolism, which could lead the way to better treatments for obesity and other metabolic disease.

24 Apr 2020

New database of 14,000 known macrolactones could aid future drug discovery

Researchers from North Carolina State University and Collaborations Pharmaceuticals have created a free-to-use database of 14,000 known macrolactones - large molecules used in drug development - which contains information about the molecular characteristics, chemical diversity and biological activities of this structural class.

22 Apr 2020

Experience Matters For Immune Cells

The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer.

17 Apr 2020

Identifying Potential Drugs Earlier In Discovery

Scientists have developed a technique that could significantly reduce the time of discovering potential new antibody-based drugs to treat disease.

16 Apr 2020

Protein Abundant In The Heart Plays Key Role In Blood Clotting

Heart protein cardiac myosin, which is released into the body when a person suffers a heart attack, can cause blood to thicken or clot.

3 Apr 2020

Researchers develop 3D cultured cells that mimic liver fibrosis

Headed by researchers from Japan-based Tokyo University of Agriculture and Technology (TUAT), a group of scientists has effectively established three-dimensional (3D) cultured tissue that imitates liver fibrosis, which is a major trait of non-alcoholic steatohepatitis (NASH).

2 Apr 2020

New method for mapping the structures of heparan sulfate sugars

Heparin, the blood-thinning drug, is used worldwide. However, to date, mapping of the fundamental sugar structures of heparin and the wider class of heparan sulfate sugars in cells has not been accomplished.

23 Mar 2020

Study offers detailed molecular map of interaction patterns of GPCR and different G protein subtypes

G protein-coupled receptors (GPCRs) have crucial roles to play in cell signal transduction and can be used as vital therapeutic targets for several diseases.

20 Mar 2020