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Fission Yeast Analysis Reveals Two Key Genes Involved in Gross Chromosomal Rearrangement

When creating a computer program, errors in the code can introduce bugs to the software. Similarly, errors in our body's genetic code, DNA, which is stored in structures known as chromosomes, can bring about mutations in the body.

26 May 2023

Fructose is Needed for Enhanced Egg Production in Fruit Flies, Study Reveals

To many people, the sugars we eat may seem like a luxury that can do more harm than good. But now, researchers from Japan have discovered that in insects, dietary sugars play a key role in reproduction.

25 May 2023

Activated B Cells in Gastrointestinal Tract Contribute to the Development of Liver Cancer

Inflammatory fatty liver disease (NASH, non alcoholic steatohepatitis ) and the resulting liver cancer are driven by autoaggressive T cells. Scientists from the German Cancer Research Center (DKFZ) now show what ist behind this destructive behavior. I

24 May 2023

New Insight into the Dynamics of a Ribosomal Protein - RPL3L

A team of researchers have discovered that a mutation in a ribosomal protein found specifically in heart and skeletal muscle leads to impaired cardiac contractility in mice.

23 May 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Research Details the Food Safety Profile of Genetically Edited Allergen-Free Eggs

Researchers have developed a chicken egg that may be safe for people with egg white allergies. Chicken egg allergies are one of the most common allergies in children.

18 May 2023

New Insights Into How Diverse Chromosomal Alterations Form and Drive Cancer Development

The goal of every dividing cell is to accurately segregate its genome into two genetically identical daughter cells.

12 May 2023

Essential Oil From the Leaves of Labrador Tea Plant Has Antimalarial Properties

Much of what is now considered modern medicine originated as folk remedies or traditional, Indigenous practices. These customs are still alive today, and they could help address a variety of conditions.

12 May 2023

Researchers Reveal the Initiation and Early Stages of Tube Formation in the Sea Star

One of the most basic and crucial embryonic processes to unfold in virtually every living organism is the formation of hollow, tubular structures of various kinds.

10 May 2023

NSU Research Unlocks How Bacteria "Work Together" to Exacerbate Infections

"Know thy self; know thy enemy" - Sun Tzu. That quote is from centuries ago, but it is applicable in so many ways.

9 May 2023

Tokyo Tech Researchers Discover How Surface Chemistry can Influence Adhesion of Bacterial Cells

The biofilm-forming bacteria E. coli adheres firmly to hydrophobic and hydrophilic protein-adsorbing self-assembling monolayers (SAMs) and weakly to hydrophilic protein-resisting SAMs, uncovered a recent study by Tokyo Tech researchers.

8 May 2023

Study Sheds Light on How Foxp2 Gene Controls the Ability to Produce Speech

Mutations of a gene called Foxp2 have been linked to a type of speech disorder called apraxia that makes it difficult to produce sequences of sound. A new study from MIT and National Yang Ming Chiao Tung University sheds light on how this gene controls the ability to produce speech.

5 May 2023

Immune Evasion Mechanism of TNBC Cells Discovered

Freiburg researchers discover a mechanism by which cancer cells escape the immune system.

5 May 2023

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

Cancer immunotherapy has transformed the treatment of many types of cancer. Yet, for reasons that remain poorly understood, not all patients get the same benefit from these powerful therapies.

4 May 2023

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

Prostate cancer frequently metastasizes to the bone and is incurable. Moffitt Cancer Center researchers are working to identify new treatment options for this subset of patients.

4 May 2023

Study Advances Understanding of the Deep Evolutionary History of Viruses

Researchers have proposed a new evolutionary model for the origin of a kingdom of viruses called Bamfordvirae, suggesting a billion-years evolutionary arms race between two groups within this kingdom and their hosts.

3 May 2023

Occludin Protein Plays a Critical Role in Cell-to-Cell Transmission of SARS-CoV-2 Virus

While the coronavirus continues to infect people around the world, researchers at the University of Missouri have identified a specific protein inside the human body that plays a critical role in how the virus spreads from cell to cell after infection -; a discovery that will help better understand the COVID-19 disease and could lead to the development of new antiviral drugs in the future.

2 May 2023

3D Genome Mapping may Lead to Targeted Therapeutic Options for Ependymoma

Researchers led by Sanford Burnham Prebys assistant professor Lukas Chavez, Ph.D., are leveraging the latest technology to take a never-before-seen look at ependymoma, one of the deadliest pediatric brain tumors.

28 Apr 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

The April 2023 issue of SLAS Discovery contains six full-length articles and one mini-review covering high-throughput screening (HTS) for protease-inhibiting drugs, high-content phenotypic screening and other life sciences research.

28 Apr 2023

Education News and Research

Fission Yeast Analysis Reveals Two Key Genes Involved in Gross Chromosomal Rearrangement

Fructose is Needed for Enhanced Egg Production in Fruit Flies, Study Reveals

Activated B Cells in Gastrointestinal Tract Contribute to the Development of Liver Cancer

New Insight into the Dynamics of a Ribosomal Protein - RPL3L

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Research Details the Food Safety Profile of Genetically Edited Allergen-Free Eggs

New Insights Into How Diverse Chromosomal Alterations Form and Drive Cancer Development

Essential Oil From the Leaves of Labrador Tea Plant Has Antimalarial Properties

Researchers Reveal the Initiation and Early Stages of Tube Formation in the Sea Star

NSU Research Unlocks How Bacteria "Work Together" to Exacerbate Infections

Tokyo Tech Researchers Discover How Surface Chemistry can Influence Adhesion of Bacterial Cells

Study Sheds Light on How Foxp2 Gene Controls the Ability to Produce Speech

Immune Evasion Mechanism of TNBC Cells Discovered

Study Reveals an Immunological Strategy to Overcome Microbiome-Related Immunotherapy Resistance

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

Study Advances Understanding of the Deep Evolutionary History of Viruses

Occludin Protein Plays a Critical Role in Cell-to-Cell Transmission of SARS-CoV-2 Virus

3D Genome Mapping may Lead to Targeted Therapeutic Options for Ependymoma

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

CITES: Regulating the International Wildlife Trade to Preserve the Viability of Species

How can the adoption of AI technology accelerate drug discovery?

Gaining insights into human disease biology through CRISPR platforms

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