Homologous Recombination News and Research

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DNA Repair Breakthrough: Scientists Reveal RecA's Precise Helix Navigation

Researchers from Tokyo Metropolitan University have been studying DNA repair by homologous recombination, where the RecA protein repairs breaks in double-stranded DNA by incorporating a dangling single-strand end into intact double strands, and repairing the break based on the undamaged sequence.

22 Jan 2024

NICER Gene Editing Technique Reduces Unintended Mutations

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

3 Apr 2023

Discovery could establish an effective control environment for chromosome instability

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

New insights into the distribution and regulation of meiotic DSB hotspots

A new method, DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling was developed recently.

3 Mar 2023

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Researchers at the Francis Crick Institute, in partnership with Artios, have discovered how an enzyme involved in DNA repair (POLQ) becomes critical to the survival of some tumors when the cancer cells lose the ability to employ a more frequent way of DNA repair.

1 Dec 2022

New transferrable and integrative type I CRISPR-based platform to efficiently edit superbugs

A research team led by Dr Aixin YAN, Associate Professor from the Research Division for Molecular & Cell Biology, Faculty of Science, in collaboration with Honorary Clinical Professor Patrick CY WOO from the Department of Microbiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, reported the development of a transferrable and integrative type I CRISPR-based platform.

23 Jul 2021

Insights on double-strand break repair may provide better understanding of cancer development

The BRCA1 protein known widely for its role in hereditary breast cancer is also a vital part of the cellular system repairing double-stranded DNA breaks.

From Osaka University 16 Jul 2021

Researchers establish efficient genetic engineering platform in Pichia pastoris

Pichia pastoris is a model methylotrophic yeast that can easily realize high-density fermentation.

13 Jul 2021

Carrying out CRISPR/Cas9 in Space

In our latest interview, AZoLifeSciences spoke to a team of researchers about their latest research which involved carrying out CRISPR/Cas9 in Space.

8 Jul 2021

Study reveals mechanisms behind the activation of MRN complex

Researchers from the Tokyo Institute of Technology have revealed mechanisms behind the stimulation of the MRN complex—the DNA scissors of the cells.

11 Mar 2021

Study may lead to new treatments for certain types of disease

Researchers at the Francis Crick Institute have found a new way to prevent some tumours from repairing their own DNA, a function that is essential for cancer cell survival. This discovery could lead to much needed new treatments for certain types of the disease.

17 Dec 2020

DNA repair tool is tailored to deal with specific type of complex break, study shows

Our cells are constantly dividing, and as they do, the DNA molecule - our genetic code - sometimes gets broken. DNA has twin strands, and a break in both is considered especially dangerous.

7 Jul 2020

Study sheds light on DNA sculpting properties of enigmatic protein

Sometimes, when something is broken, the first step to fixing it is to break it even more. In a recent example, scientists seeking to understand the mechanism of a DNA-repairing enzyme have discovered that the molecule performs its functions by first marking and then further breaking damaged DNA.

22 Jun 2020

Homologous Recombination News and Research

DNA Repair Breakthrough: Scientists Reveal RecA's Precise Helix Navigation

NICER Gene Editing Technique Reduces Unintended Mutations

"Visual Biochemistry" Approach to Understand How the BRCA2 Protein Binds and Interacts with DNA

Discovery could establish an effective control environment for chromosome instability

New insights into the distribution and regulation of meiotic DSB hotspots

Revealing the unappreciated role of POLQ in responding to DNA replication stress

New transferrable and integrative type I CRISPR-based platform to efficiently edit superbugs

Insights on double-strand break repair may provide better understanding of cancer development

Researchers establish efficient genetic engineering platform in Pichia pastoris

Carrying out CRISPR/Cas9 in Space

Study reveals mechanisms behind the activation of MRN complex

Study may lead to new treatments for certain types of disease

DNA repair tool is tailored to deal with specific type of complex break, study shows

Study sheds light on DNA sculpting properties of enigmatic protein

New insights into recombination of sex chromosomes during meiosis

Choosing alternate pathways of DNA repair to limit harmful chromosomal rearrangements

NMR spectroscopy reveals mechanisms involved in DNA repair

Study reveals key mechanism behind DNA repair processes

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