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Study Unravels How Tumors Evade Immune Response by Targeting T Cells

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer.

25 Apr 2024

Immune System's Standby Mode: Healthy Tissue Keeps Defenses Ready

When pathogens invade the body, the immune system must react immediately to prevent or contain an infection.

25 Apr 2024

Small RNA-Binding Protein Promotes Prime Editing Efficiency

Through years of engineering gene-editing systems, researchers have developed a suite of tools that enable the modification of genomes in living cells, akin to 'genome surgery'.

23 Apr 2024

Unveiling Cannabinoid’s Potential for Treating Age-Related Brain Degeneration

Scientists at the Salk Institute observed the neuroprotective effects of cannabinol in fruit flies and discovered cannabinoid analogs that may prove to be promising future treatments for Parkinson's, Alzheimer's, and traumatic brain injury.

18 Apr 2024

U of T Scientists Make Breakthrough Discovery in DNA Repair Mechanism

Researchers at the University of Toronto have discovered a DNA repair mechanism that advances understanding of how human cells stay healthy, and which could lead to new treatments for cancer and premature aging.

18 Apr 2024

Mysterious Plasmid in Human Gut Holds Potential for Health Hazard Detection

A component of the human intestinal flora that has been little studied to date is the focus of a new study.

17 Apr 2024

Nasal Cells in Children Shield Against Severe COVID-19

Children usually have milder COVID-19 symptoms; this could be due to differences in how elderly and young people's nasal cells react to the SARS-CoV-2 virus.

16 Apr 2024

Genetic Link to Persistent HPV Infections Identified

Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide.

15 Apr 2024

Genomic Deletions Drive Development of Melanoma Drug Resistance

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment.

15 Apr 2024

Study Reveals Genetic Underpinnings for Cervical Cancer Risk from Persistent HPV Infections

Human papillomavirus (HPV) is the second most common cancer-causing virus, accounting for 690,000 cervical and other cancers each year worldwide.

12 Apr 2024

Precision Combination Therapy Better Controls High-Risk Subtypes of B-ALL in Mouse Models

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

9 Apr 2024

Engineering Live Vaccines for Improved Immune Response

Bacterial proteins frequently outsmart the immune system, making it more challenging to fight off the bacteria that cause illnesses like staph infections.

5 Apr 2024

RNA Modification Offers Hope for Treating Neurological Diseases

The research team led by Yongchao C. Ma, Ph.D., at the Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago, uncovered a fundamental biological mechanism that holds promise for the development of novel treatments for neurological disorders like spinal muscular atrophy (SMA) and autism, as well as various types of cancer.

5 Apr 2024

Gut Microbiota Signatures Linked to KRAS Mutations in Colorectal Cancer Patients

For about 40% of people diagnosed with colorectal cancer (CRC), the tumor carries a mutation in a gene called KRAS. Many of those mutations have been linked to shorter survival and more aggressive forms of disease.

5 Apr 2024

Using Nanoparticles to Inactivate Multidrug-Resistant Bacteria

An article published in the Journal of Environmental Chemical Engineering describes a possible strategy for promoting selective inhibition of multidrug-resistant bacteria, which are increasingly abundant owing to the indiscriminate use of antibiotics and are therefore a major human health hazard.

4 Apr 2024