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Previously unknown telomere and cancer connection to the immune system revealed

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

31 Mar 2023

Clearance of senescent cells by boosting anti-viral immune response

Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders.

31 Mar 2023

Study expands understanding of PAK1-related IDDMSSD

A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein.

30 Mar 2023

3D cell culture system may be a valuable tool for assessing drug efficacy on tumor growth

Fibroblasts build and maintain the extracellular matrix, or physical scaffolding for cells, in the connective tissues within the body.

29 Mar 2023

Understanding the cellular effects of antibiotics targeting cell wall biosynthesis

It is still unclear how antibiotics work to destroy bacteria. This knowledge, however, is required for the development of new antibiotics. That is exactly what is required because bacteria are becoming increasingly resistant to existing antibiotics.

27 Mar 2023

Innovative new approach to constructing a nose in young patients with arhinia

Congenital arhinia (meaning patients born without a nose) is a rare condition associated with high mortality if not identified.

24 Mar 2023

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

23 Mar 2023

Researchers discover a new intracellular "smoke detector"

Researchers at the Universities of Bonn and Singapore have discovered a new intracellular "smoke detector." The sensor warns of damage to the mitochondria - the microscopic power plants that supply the cell with energy.

22 Mar 2023

Inaugural college and career program for oncology, hematology patients helps 'unlock' their future

On Thursday, March 2, 42 teens and young adults, all patients in the Adolescent and Young Adult Oncology Program (AYA), attended “Unlock Your Future,” the inaugural college and career program for oncology and hematology patients.

21 Mar 2023

T cell-driven changes in the gut may affect brain function associated with depression

In experiments with mice and humans, a team led by Johns Hopkins Medicine researchers says it has identified a particular intestinal immune cell that impacts the gut microbiome, which in turn may affect brain functions linked to stress-induced disorders such as depression.

21 Mar 2023

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

New combination therapy regimen may reduce prostate cancer progression or death by 37%

TALAPRO-2, a study led by Neeraj Agarwal, MD, FASCO, demonstrated that using TALZENNA, in combination with XTANDI, may reduce the risk of disease progression or death by 37%.

20 Mar 2023

Cancer cells use new DNA repair mechanism to recover from next-generation cancer radiation therapy

A team of scientists led by Dr. Kei-ichi TAKATA from the Center for Genomic Integrity within the Institute for Basic Science (IBS), has discovered a new type of DNA repair mechanism that cancer cells use to recover from next-generation cancer radiation therapy.

20 Mar 2023

Previously unknown genetic causes of three rare conditions discovered

Using a new computational approach they developed to analyze large genetic datasets from rare disease cohorts, researchers at the Icahn School of Medicine at Mount Sinai and colleagues have discovered previously unknown genetic causes of three rare conditions: primary lymphedema (characterized by tissue swelling), thoracic aortic aneurysm disease, and congenital deafness.

20 Mar 2023

Researchers discover previously unknown genetic causes of three rare conditions

17 Mar 2023

Influence of molecular component of caffeine on gut health

Certain microbes are considered to play a role in the development of inflammatory disorders such as inflammatory bowel disease (IBD).

16 Mar 2023

Study reveals the cellular composition and circuit organization of the locus coeruleus

A small nucleus in the brainstem called locus coeruleus (literally the "blue spot,") is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the 'fight or flight' response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons.

16 Mar 2023

Hospital News and Research

Previously unknown telomere and cancer connection to the immune system revealed

Clearance of senescent cells by boosting anti-viral immune response

Study expands understanding of PAK1-related IDDMSSD

3D cell culture system may be a valuable tool for assessing drug efficacy on tumor growth

Understanding the cellular effects of antibiotics targeting cell wall biosynthesis

Innovative new approach to constructing a nose in young patients with arhinia

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Researchers discover a new intracellular "smoke detector"

Inaugural college and career program for oncology, hematology patients helps 'unlock' their future

T cell-driven changes in the gut may affect brain function associated with depression

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

New combination therapy regimen may reduce prostate cancer progression or death by 37%

Cancer cells use new DNA repair mechanism to recover from next-generation cancer radiation therapy

Previously unknown genetic causes of three rare conditions discovered

Researchers discover previously unknown genetic causes of three rare conditions

Influence of molecular component of caffeine on gut health

Study reveals the cellular composition and circuit organization of the locus coeruleus

High doses of sucralose limit T cell proliferation and differentiation

Study examines the role of dietary vitamin A in preventing or treating AAP

Age-related sarcopenia prevented by AAV1.NT-3 gene therapy

How can the adoption of AI technology accelerate drug discovery?

Gaining insights into human disease biology through CRISPR platforms

Genome Editing Has A New Code

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