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Microglia Replacement Halts Progression of Fatal Neurological Disease in Mice and Humans

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset of 43 years and an average life expectancy of only 3 to 5 years after symptoms begin.

11 Jul 2025

SNAP-tag2 System Improves Protein Imaging with Faster, Brighter Labeling

SNAP-tag2 boosts live-cell imaging with faster labeling, brighter fluorescence, and better protein tracking across biological systems.

11 Jul 2025

New Protein Superfamily Redefines Bacterial Interactions

A newly identified bacterial protein, PopA, reveals complex interactions in bacteria, challenging existing models of membrane protein formation.

9 Jul 2025

Obesity-Related Cognitive Deficits Improved Through Astrocyte Modulation

Fatty diets and obesity affect the structure and function of astrocytes, the star-shaped brain cells located in the striatum, a brain region involved in the perception of pleasure generated by food consumption.

8 Jul 2025

Scientists Discover Unique Bacterial Protein That Traps Membrane Lipids

Scientists have identified a new type of protein in bacteria that could change our understanding of how these organisms interact with their environments.

8 Jul 2025

Study Links Cell Surface Receptor Pairing to Proper Embryonic Body Shape

During animal development, cells divide and arrange themselves in a coordinated way, eventually forming the embryo.

4 Jul 2025

Fruit Fly Study Uncovers Key Mechanisms Behind Collective Cell Migration

Researchers uncover how Plexin A and Semaphorin 1b regulate collective cell migration in fruit fly testes, offering insights into organ development, cancer metastasis, and tissue engineering.

26 Jun 2025

Fluorescent Molecules Offer Unprecedented Insight into Cell Structures

Scientists have long used fluorescent dyes—which emit light—to research cell structures and activities.

25 Jun 2025

UT Southwestern Researchers Develop Multi-Organ Gene Editing Strategy

A gene-editing delivery system developed by UT Southwestern Medical Center researchers simultaneously targeted the liver and lungs of a preclinical model of a rare genetic disease known as alpha-1 antitrypsin deficiency (AATD), significantly improving symptoms for months after a single treatment, a new study shows.

23 Jun 2025

New Technique Enhances Three Dimensional Immunolabeling in Thick Tissues

Three dimensional immunohistochemistry (3D-IHC) has transformed our ability to visualize the spatial arrangement of cells and molecules in intact tissues.

20 Jun 2025

New STAMP Technique Combines Microscopy with Single-Cell RNA Analysis

Single-cell RNA sequencing provides scientists with important information about gene expression in health and disease.

18 Jun 2025

Hippocampal Neurons Show Surprising Flexibility in Brain Signal Processing

The brain is constantly mapping the external world like a GPS, even when we don't know about it. This activity comes in the form of tiny electrical signals sents between neurons -- specialized cells that communicate with one another to help us think, move, remember and feel.

17 Jun 2025