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Exploring how smoking cannabis alters the oral microbiome and its impact on the brain

Inspiration strikes when you least expect it. For Wei Jiang, M.D., a professor of Microbiology and Immunology at the Medical University of South Carolina (MUSC), inspiration came in 2018 on a smoke-filled boat tour around Amsterdam during an international conference.

30 Jan 2023

Accumulation of collagen at injured sites in the gut stimulates cellular reprogramming, study reveals

Most cells have a pretty normal life: they're born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.

30 Jan 2023

Gene editing made faster than ever before using AI

The first simple production of customizable proteins known as zinc fingers to treat diseases by turning genes on and off might be enabled with the help of an artificial intelligence (AI) program.

From New York University (NYU) 27 Jan 2023

MicroRNA’s influence on lupus disease inflammation

Researchers from Nagoya University’s Graduate School of Medicine in Japan have uncovered how microRNA (miRNA) affects inflammation in mice with lupus. They discovered two downregulated miRNAs in the disease along with a rare circumstance where several miRNAs control the same set of genes.

27 Jan 2023

New solution to treat diseases caused by exaggerated inflammation

A recent study guided by the Instituto Gulbenkian de Ciência (IGC) shows how anticancer drugs reduce inflammation, establishing them as prospective sepsis treatments.

11 Jan 2023

Novel blood biomarker predicts a favorable response to CART cell therapy

A MedUni Vienna research group identified a particularly potent biomarker for clinical response to CAR-T cell therapy, establishing the conditions for the most effective use of this innovative therapy for lymphoma treatment.

11 Jan 2023

New technologies reveal cross-cutting breakdowns in Alzheimer’s disease

A figure from the paper depicts pathways perturbed in Alzheimer's disease. Below examples are listed for each pathway by major brain cell type. Image Credit: The Picower Institute.

4 Jan 2023

Uncovering new function for small RNAs in Salmonella infections

Millions of people get sick from Salmonella each year because they are food-borne pathogens. These bacteria rely on a sophisticated network of genes and gene products that give them the ability to sense environmental conditions to do this.

4 Jan 2023

Common food dye can be a potential dietary trigger for IBDs, study shows

Long-term consumption of Allura Red food dye can be a potential trigger of inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, says McMaster University's Waliul Khan.

21 Dec 2022

Key immune alarm protein that regulates inflammation identified

Trinity researchers have made a significant advance in understanding how inflammation is controlled. They recently discovered that a crucial immunological alarm protein that was previously thought to quiet the immune response apparently performs the opposite.

20 Dec 2022

Involvement of the piRNA pathway in brain plasticity and successful aging

The Neurobiology of miRNA team, headed by Davide De Pietri Tonelli of the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology), established a link between a family of small RNA molecules known as piRNAs and brain inflammation.

16 Dec 2022

Small fluorescent protein helps researchers to capture deeper, more precise biomedical images

Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.

7 Dec 2022

Microglial cells trigger inflammatory protective mechanisms in the immune system

Microglia, the brain’s own immune cells, are present in the central nervous system.

1 Dec 2022

Mitochondria play a crucial role in the regulation of the NF-κB signaling pathway

Mitochondria are highly regarded as the cell's powerhouse. However, these cellular organelles are essential for more than only energy production: Professor Konstanze Winklhofer and her colleagues at Ruhr University Bochum’s Faculty of Medicine have found that mitochondria play an essential role in signal transduction in innate immune pathways.

21 Nov 2022

Role of VWF in triggering inflammation

The blood clotting protein von Willebrand Factor (VWF) has a new function that has been identified by researchers at RCSI University of Medicine and Health Sciences.

4 Nov 2022

The primary functions of innate immune cells

An inflammation and a rise in mucus production are typical signs of allergies and worm infections. The innate immune cells are involved in this immunological response, although it is still unclear exactly what they do.

4 Nov 2022

New drug to tackle complex cases of UTI

A new drug combination has been shown to be more successful, especially against persistent, drug-resistant infections, according to an international study conducted by a Rutgers Researcher comparing new and older therapies for complex urinary tract infections.

From Rutgers University 28 Oct 2022

New gene linked to the growth of colon cancer discovered

Researchers at Mount Sinai’s Tisch Cancer Institute have discovered a new gene that is crucial to the development of colon cancer and established that inflammation in the region surrounding the tumor can contribute to the development of tumor cells.

20 Oct 2022

Gut microbiome’s influence on how lifestyle affects dementia risk

A recent Baycrest study points to the possibility that the gut microbiome influences how nutrition and exercise impact brain health and dementia risk. Physicians and researchers could be able to improve dementia prevention efforts with the use of this knowledge.

13 Oct 2022

New technique identifies tumor-associated microbes

Researchers from Rutgers Cancer Institute of New Jersey and RWJBarnabas Health investigated the microbiome of pancreatic tumors and discovered certain microbes linked to inflammation and poor survival.

From Rutgers University 12 Oct 2022