Insulin is a hormone that is needed to convert glucose, starches and other food into energy needed for daily life. Insulin allows cells to use glucose for fuel and is secreted by beta cells in the islets of Langerhans. The release of insulin from the pancreas is stimulated by increased blood glucose, vagal nerve stimulation, and other factors. Insulin is obtained from various animals and available in a variety of preparations. Commercial insulin preparations differ in a number of ways, including differences in the animal species from which they are obtained; their purity, concentration, and solubility; and the time of onset and duration of their biologic action. An oral hypoglycemic agent is not a form of insulin therapy.
A better understanding of cellular interactions is crucial to interpret several biological diseases and systems.
Currently, there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.
Professor Sang Woo’s research group has designed a synthetic protein quality control system to improve the full-length translation in bacteria.
A City of Hope-led research team found that the same gene that increases the risk for Alzheimer's disease, ApoE4, can increase the susceptibility to and severity of COVID-19.
A new study headed by the Ohio State University Wexner Medical Center and the College of Medicine has found a new compound that could form the base for creating a new class of diabetes drugs.
A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop the metabolic disease during their lifetime, as suggested by previous research.
Immediately after a traumatic brain injury and as long as one year later, there are increased levels of immune cells called ILCs in the brain promoting inflammation, which can worsen brain damage, scientists report.
In science, sometimes a new perspective can turn our interpretation of the data upside-down, and necessitate a paradigm shift.
UC San Francisco scientists have discovered a new way to control the immune system's "natural killer" (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.
Researchers from Tokyo Medical and Dental University (TMDU) identify a novel mechanism by which periodontal disease may cause diabetes
Scientists from the University of Utah School of Medicine have discovered a novel therapeutic target to treat type 1 diabetic patients.
People with pre-diabetes or diabetes who live in ozone-polluted areas may have an increased risk for an irreversible disease with a high mortality rate.
Scientists have revealed that fluorescent protein molecules serve as antennas with optical characteristics according to their spatial orientation.
Blackcurrants have a beneficial effect on post-meal glucose response, and the required portion size is much smaller than previously thought, a new study from the University of Eastern Finland shows.
A drug originally developed to treat bacterial infections has proved capable of boosting the metabolism and attenuating the weight gain induced by a fatty diet in tests with mice. The study was conducted at the University of Campinas (UNICAMP) with FAPESP's support, and the findings have just been published in the journal Science Advances.
An international team of researchers has explained the action mechanism of incretin-based medications in diabetes treatment.
The production of fat in the human body is essentially regulated by gut hormones.
Scientists have found that insulin has met an evolutionary cul-de-sac, limiting its ability to adapt to obesity and thereby rendering most people vulnerable to Type 2 diabetes.
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease.
Five research projects with exceptional promise to deliver new life-changing and health-altering therapies have received the inaugural Blavatnik Therapeutics Challenge Awards (BTCA) at Harvard Medical School.