Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Neural Mechanism Involved in Leptin Resistance Revealed

Worldwide obesity rates have more than doubled since 1990, with nearly a billion people now falling into the category.

5 Mar 2025

New Approach Could Protect Insulin-Producing Beta Cells from Damage Related to Diabetes

Researchers from the Icahn School of Medicine at Mount Sinai in New York have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity-a harmful condition linked to the progression of type 2 diabetes (T2D).

5 Mar 2025

PanK4 Protein Could Be Key to Better Control of Blood Sugar and Metabolism

Physical activity is not only important for fitness, but also for health. This is confirmed by a new study conducted under the direction of Prof. Dr. Maximilian Kleinert at the German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE). His team discovered that the protein PanK4 plays a crucial role in the energy metabolism of skeletal muscles.

13 Feb 2025

Study Offers a New Perspective on the Evolution of Large Human Brains

Brain tissue is among the most energetically costly in the body, and as a result, larger-brained mammals require more energy to support brain growth and maintenance.

3 Dec 2024

Reduced Protein Mobility Linked to Chronic Diseases and Their Complications

Chronic diseases like type 2 diabetes and inflammatory disorders have a huge impact on humanity. They are a leading cause of disease burden and deaths around the globe, are physically and economically taxing, and the number of people with such diseases is growing.

28 Nov 2024

SGLT-2 Inhibitors May Lower Dementia Risk in Type 2 Diabetes Patients, Study Finds

A study reveals SGLT-2 inhibitors significantly reduce dementia risk in type 2 diabetes patients, with effects strengthening over longer treatment durations.

9 Sep 2024

New Population of Cells in Human Omental Fat Tissue Found to Hinder Adipogenesis

Understanding how fat tissue forms and functions is crucial for addressing obesity and related metabolic diseases. However, adipose tissue, or body fat, behaves differently based on its location in the body.

10 May 2024

Placenta's Role in Gestational Diabetes Revealed

A recent study led by the Harvard Pilgrim Health Care Institute has discovered that a deficiency in placental expression of the gene insulin-like growth factor 1 (IGFBP1) and low circulating levels of IGFBP1 are linked to insulin resistance during pregnancy, indicating a potential risk factor for the onset of gestational diabetes.

17 Apr 2024

Study Reveals Unique Bacterial Fingerprints and Their Impact on Health

The trillions of bacteria that call your body home -; collectively known as the microbiome -; appear to be unique to you, like a fingerprint.

13 Mar 2024

Strategies to Counter Postnatal Growth Retardation in Piglets

The metabolic basis of postnatal growth retardation (PGR) in piglets is not yet clear, but it is characterized by poor production performance, low feed conversion rate, and a high mortality rate.

4 Mar 2024

Study Shows How Obesity Causes Mitochondrial Fragmentation in Fat Cells

The number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic.

30 Jan 2024

Lipidome Study Reveals New Insights Into Human Health

The sequencing of the human genome promised a revolution in medicine, but scientists soon realized that a genetic blueprint alone does not show the body in action.

12 Sep 2023

Revealing a Novel Signaling Pathway Fostering Aging-Related Chronic Metabolic Disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

4 Aug 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

Disclosing the Key Role of Mitofusin 2 Cellular Makeup in Interconnecting Organelles Within Cells

Researchers at IRB Barcelona, the University of Barcelona (UB), VIMM, and the University of Padua unveil the key role of Mitofusin 2 cellular makeup in interconnecting organelles within cells.

29 Jun 2023

Lundquist Institute Contributes to Genetic Study of Insulin Response to a Glucose Challenge

The Lundquist Institute (TLI) announced that its Institute for Translational Genomics and Populations Sciences contributed to a new study published today in Nature Genetics of the DNA of more than 55,000 people worldwide.

12 Jun 2023

How Do Humans Maintain a Healthy Blood Sugar Level After Meals?

A study of more than 55,000 people’s DNA from around the world has given insight into how humans maintain appropriate blood sugar levels after eating, with implications for the current understanding of how the process goes awry in type 2 diabetes.

9 Jun 2023

Researchers Advance the Breeding of High-Resistant Starch Rice

Researchers have demonstrated that the loss of function of two paralogous starch biosynthesis genes increases the amount of resistant starch (RS) in cooked rice.

8 May 2023

Two subtypes of cells that produce insulin discovered

A team of scientists from the Van Andel Institute and the Max Planck Institute for Immunobiology and Epigenetics uncovered two unique subtypes of insulin-producing beta cells, or ß cells, each having important traits that could potentially be used to better understand and treat Type 1 and Type 2 diabetes.

30 Mar 2023

New insights into genetics of sexually dimorphic fat distribution in humans

Obesity causes many health problems and worsens several chronic illnesses, including type 2 diabetes and cardiovascular disease, however, some obese people are more susceptible to complications than others.

17 Feb 2023