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Challenges in Drug Discovery; Where are we now, and where are we going?

As part of our SLAS Europe 2022 coverage, we speak to Steve Rees, Vice-President of Discovery Biology at AstraZeneca, about the challenges currently faced by the drug discovery sector.

From Society for Laboratory Automation and Screening (SLAS) 8 Jul 2022

Study reveals how RNAi workhorse protein optimizes to keep protein synthesis on track

Proteins are made in cells in the same way as they are made in factories. However, making too much at the wrong moment may lead to illnesses like cancer, so they use RNA interference (RNAi) to regulate production.

1 Jun 2022

Cancer biomarkers relying on methylation could forecast tumor type

In cancer management, biomarkers are commonly used to guide treatment decisions and evaluate patient outcomes.

23 May 2022

Researchers discover protein that enhances muscle mass

Humans are not just pumping iron in the gym, or not just oxygenating muscle cells, which keeps those muscles healthy, powerful, and developing—a process known as hypertrophy—that is defined as an increase in muscle mass, caused by an increase in muscle cell size.

29 Apr 2022

Study addresses genetic diversity of Clostridioides difficile using systems biology technique

Researchers from Jacobs School of Engineering and the University of California San Diego School of Medicine collaborated with colleagues from Baylor College of Medicine to decode the genetic diversity of Clostridioides difficile, an especially dangerous pathogen in healthcare settings, using a systems biology technique.

29 Apr 2022

SARS-CoV-2 can directly infect a specialized type of kidney cell

The virus that causes COVID-19, SARS-CoV-2, can directly infect a specialized type of kidney cell.

22 Apr 2022

Vitamin E can reinvigorate dendritic cells to enhance immunotherapy responses

Combining a retrospective analysis of clinical records with in-depth laboratory studies, researchers at The University of Texas MD Anderson Cancer Center have discovered that vitamin E can enhance immunotherapy responses by stimulating the activity of dendritic cells in the tumor.

18 Apr 2022

Certain RNA molecules may serve as markers of cellular stress in different diseases

The body's ability to respond to various types of stress is essential for maintaining health, and failure of such adaptive stress responses can trigger or worsen numerous diseases.

6 Apr 2022

Checkpoint immunotherapy acts as an interface between killer T cells and dendritic cells

Chronic viral infections and cancers can damage the immune system permanently, diminishing the ability of immune killer T cells to destroy tumor cells or virus-infected cells—a condition known as “immune exhaustion.”

5 Apr 2022

Researchers discover a gene linked to touch in sea anemones as well as hearing in humans

An international team of investigators, including several researchers in biological sciences from the U of A, have published a paper that reports the discovery of a developmental gene linked to touch in the tentacles of sea anemones as well as hearing in humans.

4 Apr 2022

Globins in the body help fight liver disease

Anti-fibrotic therapy is still a medical necessity in the treatment of chronic liver disease in humans. The anti-fibrotic activity of globin family members in hepatic stellate cells (HSCs), the principal cell type involved in liver fibrosis, was reported by a research group led by Professor Norifumi Kawada of Osaka Metropolitan University (OMU).

24 Mar 2022

Scientists develop a novel approach, enabling spatial mapping of single-cell data within tissue

Scientists develop a new approach that efficiently integrates information from parallel gene-expression profiling methods at single-cell resolution.

23 Mar 2022

Researchers investigate genomic data discrepancies among racial groups

The Cancer Genome Atlas, one of the biggest cancer research databases, was used by Mayo Clinic researchers to investigate disparities in genomic data quality.

21 Mar 2022

Researchers use GP2 and UMOD to prevent urinary tract infection

A team led by Karolinska Institute used AI and structural biology to learn more about two similar proteins that protect against bacterial infection in the urinary tract.

16 Mar 2022

Several variants of COVID-19 may hide away from body’s immune system, new study reveals

A recent study published in Nature Communications by an international research group suggests that people infected with COVID-19 may have several distinct SARS-CoV-2 variants stashed away from the immune system in various parts of the body.

3 Mar 2022

Researchers design a new imaging approach to accelerate imaging-based research

A new imaging method has been designed and tested by scientists from Johns Hopkins Medicine.

2 Mar 2022

Scientists use CRISPRa to discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

4 Feb 2022

Mother's unhealthy vaginal microbiome may contribute to mortality and altered development in babies

A new study in mice from University of Maryland School of Medicine researchers showed that an unhealthy vaginal microbiome in pregnant mothers in combination with an unhealthy diet contributed to increased pup deaths and altered development in the surviving babies.

28 Jan 2022

Researchers map the cellular landscape in diabetic foot ulcers

Diabetic foot ulcerations – open sores or wounds that refuse to heal – are a devastating complication affecting more than 15 percent of people with diabetes and resulting in more than 70,000 lower extremity amputations per year in the United States alone.

11 Jan 2022

Research explains how E4 peptide exerts antifibrotic effect and what makes it so effective

A research team at the Medical University of South Carolina led by Carol Feghali-Bostwick, Ph.D., reports in the Journal of Clinical Investigation Insight that the E4 peptide reverses fibrosis, or scarring, in human and mouse tissues by activating an antifibrotic pathway that is common to all organ systems.