Kinase News and Research

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Advancing Cancer Drug Discovery: The Enduring Value of Phenotypic Screening

The niche areas in which phenotypic screening continues to be advantageous over the targeted approach, and the recent advances in phenotypic screening technology that have increased their efficiency.

26 Jul 2024

Reawakened Endogenous Retroviruses can Play a Critical Role in Helping Cancer Survive

Peek inside the human genome and, among the 20,000 or so genes that serve as building blocks of life, you'll also find flecks of DNA left behind by viruses that infected primate ancestors tens of millions of years ago.

18 Jul 2024

Advancing the Understanding of Circadian Regulation with Melanopsin DNA Aptamers

DNA aptamers of melanopsin that regulate the clock hands of biological rhythms were developed by the Toyohashi University of Technology and the National Institute of Advanced Industrial Science and Technology (AIST) group.

15 Jul 2024

Enhancing Precision and Versatility in Genetic Sensor Design

Genetic sensors play a crucial role within organisms by regulating gene expression in response to environmental stimuli.

2 Jul 2024

Study Uncovers a Biological Explanation for Long-Term Memories

Whether it's a first-time visit to a zoo or when we learned to ride a bicycle, we have memories from our childhoods kept well into adult years.

27 Jun 2024

3D Cell Cultures Improve Drug Screening Accuracy but Show Lower Efficacy for Anti-Cancer Drugs

The existing knowledge on monolayers and spheroid-based cell cultures, including the constituent compounds, and the difference in efficacy during drug screening, especially for anti-cancer drugs targeting cytoskeletal dynamics and cell cycles.

21 Jun 2024

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

A synthetic platform that uses dimerization modules consisting of chemical proteins to precisely control the polymerization of actin and demonstrate symmetry breaking.

19 Jun 2024

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Whether forcing adult cardiomyocytes to reverse from the oxidative phosphorylation phenotype to the glycolysis phenotype would also restore their mitotic ability.

13 Jun 2024

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

A bacterial enzyme called histidine kinase is a promising target for new classes of antibiotics. However, it has been difficult to develop drugs that target this enzyme, because it is a "hydrophobic" protein that loses its structure once removed from its normal location in the cell membrane.

11 Jun 2024

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Scientists at the University of Dundee have uncovered the inner relay of a molecular switch that protects the brain against the development of Parkinson's disease.

10 Jun 2024

Researchers Identify Molecular Stop Signal in Cell Division Monitoring

Every second, many million cells divide throughout the body. During nuclear division (mitosis), the genetic material must be divided correctly and fully amongst daughter cells; faults in this process can result in improper development or genetic diseases, and many cancer cells have an uneven number of chromosomes.

5 Jun 2024

Stem Cell Factor Levels Show Promise in Predicting Successful IVF for Endometriosis

The ability of serum levels of stem cell factor to indicate the quality of oocyte and blastocyst development.

4 Jun 2024

Remote ischemic conditioning:A potential treatment option for necrotizing enterocolitis

Necrotizing enterocolitis is a life-threatening neonatal disease with high morbidity and mortality rates.

21 May 2024

Molecular Machinery Behind Plant Growth and Oil Production Deciphered

Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things -; and potentially how to change its effects.

20 May 2024

Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

An article published in The Faseb Journal describes a Brazilian study analyzing the correlation between two key energy metabolism regulation processes: the absorption and release of calcium ions by mitochondria, the organelles that generate energy for cells; and autophagy induced by calorie restriction.

3 May 2024

PI3K Enzyme's Dual Accelerator and Brake Mechanisms Uncovered

A group of researchers have expanded conventional knowledge on a critical enzyme that controls cell migration. In a recent publication in the journal Nature Communications, they reported that phosphoinositide 3-kinase (PI3K) not only acts as an accelerator to prompt cell motility, but it also has a built-in brake mechanism that impedes migration.

25 Apr 2024

Kinase News and Research

Advancing Cancer Drug Discovery: The Enduring Value of Phenotypic Screening

Reawakened Endogenous Retroviruses can Play a Critical Role in Helping Cancer Survive

Advancing the Understanding of Circadian Regulation with Melanopsin DNA Aptamers

Enhancing Precision and Versatility in Genetic Sensor Design

Study Uncovers a Biological Explanation for Long-Term Memories

3D Cell Cultures Improve Drug Screening Accuracy but Show Lower Efficacy for Anti-Cancer Drugs

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

Mitochondria Influence the Ability of Adult Cardiac Cells to Multiply

Water-Soluble Bacterial Enzyme Could Enable Rapid Screening of Potential Antibiotics

Dundee Scientists Reveal Inner Workings of PINK1 Molecular Switch in Parkinson's Disease

Researchers Identify Molecular Stop Signal in Cell Division Monitoring

Stem Cell Factor Levels Show Promise in Predicting Successful IVF for Endometriosis

Remote ischemic conditioning:A potential treatment option for necrotizing enterocolitis

Molecular Machinery Behind Plant Growth and Oil Production Deciphered

Unveiling the Role of NCLX Protein in Mitochondrial Calcium Regulation and Autophagy

PI3K Enzyme's Dual Accelerator and Brake Mechanisms Uncovered

Using State-of-the Art Imaging to Understand Lipid Dysfunction in Alzheimer's

Study Uncovers Cells' Surprising Strategy to Control Signaling Pathways

Novel Imaging Technique Unveils Structural Details of Drug-Resistant Cancer Protein

First Whole Genome Sequencing of Male Breast Cancer Reveals Potential Treatment Targets

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Expert Insights: HiMedia Labs on Advancing Nucleic Acid Extraction Across Industries

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