Male Infertility News and Research

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Male infertility is on the rise in society. Approximately 15% of married couples have trouble conceiving despite having regular unprotected sex for more than a year. Out of the couples who are in their thirties, only 30% are able to conceive within the first three months; the rest have trouble due to male infertility issues.

Scientists Unlock the Mechanism Behind piRNA's Defense Against Jumping Genes

Adverse genetic mutations can cause harm and are due to various circumstances. "Jumping genes" are one cause of mutations, but cells try and combat them with a specialized RNA called piRNA.

22 Mar 2025

New Research Sheds Light on Y Chromosome’s Role in Male Infertility

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

24 Jan 2025

Study Reveals Epigenetic Changes in Sperm from Non-Genetic Infertility Causes

How non-genetic factors can induce epigenetic modifications to the sperm and cause male infertility.

3 Jul 2024

Understanding the Dynamic Regulation of Manchette Microtubules in Sperm Development

A team of researchers, led by Wenxiang Meng from the Institute of Genetics and Developmental Biology at the Chinese Academy of Sciences, has demonstrated that the deletion of the calmodulin-regulated spectrin-associated protein 1 (CAMSAP1) gene in mice, which is associated with the minus ends of non-centrosomal microtubules, results in a condition known as oligoasthenoteratozoospermia.

6 Nov 2023

Prime Target for Male Contraceptive Development Identified

As far as a highly effective, reversible, and non-hormonal male contraceptive for humans and animals is concerned, the discovery of a gene in multiple mammalian species could set the stage.

18 Apr 2023

Developing Sperm Cells from Primate Stem Cells

We speak to Professor Charles Easley about his latest research into male infertility, and how sperm cells could be potentially developed from primate stem cells.

From University of Georgia 15 Dec 2021

De Novo Mutations may Play a Role in Male Infertility

In this interview, we speak to Dr. Miguel J. Xavier about his latest research into male infertility and how de novo mutations may play a part.

From Newcastle University 19 Nov 2021

Earlier known protein complex acts as a centriole stabilizer, says study

Microtubules are fibers in cells that construct a network to offer shape and structure to cells along with mediating transport mechanisms.

4 Nov 2021

Scientists identify gene crucial to sperm cell production

Scientists at Cincinnati Children's appear to have flipped another piece in the underexplored puzzle of male infertility.

27 Oct 2021

Functional sperm cells can be made in a dish using primate embryonic stem cells, study shows

With global rates of male infertility continuing to rise, a new study in spermatogonial stem cell research led by researchers at the University of Georgia provides hope for future clinical therapies.

From University of Georgia 20 Oct 2021

Researchers reveal how ubiquitous signaling molecule plays a critical role in male fertility

Mammalian sperm cannot fertilize an egg from the get-go. It's an ability acquired only after insemination, during passage through the female reproductive tract, and requires two consecutive, time-sensitive processes to provide sperm with the physical and biochemical traits necessary to complete their fundamental job.

From UC San Diego 20 Aug 2021

Natural compound acts as reversible male contraceptive pill

Researchers have developed a novel approach that has resulted in the discovery of a natural compound that acts as a male contraceptive agent.

5 Mar 2021

New delivery system may treat male infertility

According to the Mayo Clinic, about 15% of couples are infertile, and male infertility plays a role in over one-third of these cases. Often, problems with sperm development are to blame.

22 Oct 2020

Retinoic acid is the key to produce healthy offspring from testicular tissue transplantation

One in fifty births in Japan are said to be through in vitro fertilization, and many couples remain unable to conceive for reasons unknown. Infertility is also an undesired side-effect of lifesaving cancer treatment in childhood.

17 Jul 2020

C19ORF57 gene could advance reproductive medicine

The gene C19ORF57 has been identified to play a major role in meiosis by the Institute of Molecular Embryology and Genetics at Kumamoto University.

5 Jun 2020

Researchers discover new therapeutic targets for cancer, male infertility

Researchers analyzed 13,000 tumors, highlighting two formerly overlooked genes as promising new therapeutic targets for treating cancer.

7 May 2020

Novel protein facilitates a critical event in mammalian fertilization

Fertilization is a fundamental process in sexual reproduction when the combination of male and female gametes blends genetic material to create a new unique individual. Now, researchers from Japan have identified a new factor that may help orchestrate this vitally complex life event.

From Osaka University 17 Apr 2020