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How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

29 May 2023

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

The biology underpinning a rare genetic mutation that allows its carrier to live virtually pain-free, heal more rapidly and experience reduced anxiety and fear, has been uncovered by new research from UCL.

24 May 2023

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

23 May 2023

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Neuropathy is a type of chronic pain triggered by nerve injury or certain diseases. It affects millions of people worldwide, significantly deteriorating their quality of life.

5 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

A major challenge in human genetics is understanding which parts of the genome drive specific traits or contribute to disease risk. This challenge is even greater for genetic variants found in the 98% of the genome that does not encode proteins.

5 May 2023

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

Prostate cancer frequently metastasizes to the bone and is incurable. Moffitt Cancer Center researchers are working to identify new treatment options for this subset of patients.

4 May 2023

Mind-Body Connection is More Than Just an Abstraction

Calm body, calm mind, say the practitioners of mindfulness. A new study by researchers at Washington University School of Medicine in St. Louis indicates that the idea that the body and mind are inextricably intertwined is more than just an abstraction.

20 Apr 2023

Understanding the Functioning of Opioid Receptors at Unprecedented Spatial Resolution

The human body naturally produces opioid-like substances, such as endorphins, which block the perception of pain and increase the feeling of well-being.

20 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Common Epstein-Barr virus may be a trigger for multiple sclerosis

In 1868, French physician Jean-Martin Charcot, known as the founder of modern neurology, defined a disease entity in which multiple plaques formed in the brain and spinal cord, with varying physical symptoms, called Sclérose en plaques, or in English as multiple sclerosis (MS).

24 Mar 2023

Wearable microscopes produce real-time images of mouse spinal cord activity

The spinal cord acts as a messenger, carrying signals between the brain and body to regulate everything from breathing to movement.

23 Mar 2023

Curcumin could enhance ovarian cancer treatments

A pharmacology researcher at New York Institute of Technology College of Osteopathic Medicine (NYITCOM) has co-authored a new study that makes a strong case for why a golden spice commonly found in curry could enhance ovarian cancer treatments.

23 Mar 2023

How can the adoption of AI technology accelerate drug discovery?

In this interview, we speak to SLAS 2023 keynote speaker Joshua Smith from IBM Research about the importance of AI in accelerating drug discovery.

From Society for Laboratory Automation and Screening (SLAS) 22 Mar 2023

Illumina launches its first product enabling long- and short-read sequencing on one instrument

Illumina Inc., a global leader in DNA sequencing and array-based technologies, today announced that its first product based on its novel Illumina Complete Long Read technology is now available to order.

22 Mar 2023

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Over a one-third of FDA-approved drugs tend to function by targeting a G protein-coupled receptor, or so-called GPCR. The human body consists of over 800 kinds of GPCRs that offer cells with data concerning the external surrounding to calibrate responses.

20 Mar 2023

Pain News and Research

How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Research Uncovers the Biology Underpinning a Rare Genetic Mutation Linked to Painlessness

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Eliminating or Blocking the Tiam1 Gene Prevents, Reverses Chronic Neuropathic Pain

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

STING-seq Discovers Causal Variants and Genetic Mechanisms for Blood Cell Traits

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

Mind-Body Connection is More Than Just an Abstraction

Understanding the Functioning of Opioid Receptors at Unprecedented Spatial Resolution

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Common Epstein-Barr virus may be a trigger for multiple sclerosis

Wearable microscopes produce real-time images of mouse spinal cord activity

Curcumin could enhance ovarian cancer treatments

How can the adoption of AI technology accelerate drug discovery?

Illumina launches its first product enabling long- and short-read sequencing on one instrument

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

Study identifies previously unknown cell types that drive the onset of osteoarthritis

Study sheds light on unique processes that bestow naked mole-rats’ with eternal fertility

CITES: Regulating the International Wildlife Trade to Preserve the Viability of Species

How can the adoption of AI technology accelerate drug discovery?

Gaining insights into human disease biology through CRISPR platforms

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