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Blood Vessel Cells Play a Crucial Role in Bone Development

Researchers have discovered a protein that inhibits the activity of bone-forming cells (osteoblasts) by preventing their maturation during the process of migrating to bone-formation sites.

14 Oct 2024

The Promise of Venomous Crustaceans in Drug Development

Many animals use venoms for self-defense or hunting. The components of such venom, known as toxins, interfere with various physiological processes - which is also the reason why they are so interesting for the development of new pharmacological agents.

7 Oct 2024

Study Confirms Comparable Efficacy of Lamotrigine and Mexiletine in Muscle Channelopathy

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

30 Sep 2024

Genome-Scale Analysis Reveals Cholera's Evolution

The genetic components that make the cholera-causing bacterium so lethal have been identified by experts using a state-of-the-art computational method, and this information may be crucial to averting the terrible illness.

24 Sep 2024

New Research Uncovers Healing Benefits of Pyroptosis

A study by the team of Prof. Kodi Ravichandran (VIB-UGent Center for Inflammation Research) and colleagues found that pyroptosis, a form of programmed cell death traditionally thought to be purely inflammatory, also plays a crucial role in promoting healing and tissue repair.

12 Sep 2024

Genetic Variants Linked to Rare Bicuspid Aortic Valve Disease Identified

Genetic variants linked to a rare form of bicuspid aortic valve disease that affects young adults and can lead to dangerous and potentially life-threatening aortic complications have been identified by researchers at UTHealth Houston.

3 Sep 2024

Gut Microbiota Modulates Rotavirus Vaccine Effectiveness

Scientists at Georgia State University's Institute for Biomedical Sciences have shown that some gut flora can reduce the effectiveness of the rotavirus vaccine.

27 Aug 2024

Emerging Treatments and Drug Repositioning for NAFLD and NASH

The current research on drug candidates and molecular targets being clinically tested for the treatment of non-alcoholic steatohepatitis (NASH) and NAFLD.

9 Aug 2024

Breakthrough Compound ZTA-261 Shows Promise for Safer Lipid Disorder Treatment

Scientists at Nagoya University in Japan have made a significant breakthrough in treating lipid disorders.

8 Aug 2024

Mini-Gut Model Unlocks Secrets of COVID-19 Diarrhea

Researchers at Johns Hopkins Medicine claim to have identified multiple molecular pathways linked to diarrhea caused by COVID-19, offering possible therapeutic interventions utilizing human stem cells to create a sort of “mini intestine-in-a-dish.

7 Aug 2024

Mast Cells Recruit Neutrophils in Immune Response

Mast cells are well-known for their part in allergic reactions, but the immune system relies heavily on them. They release chemicals in response to allergens, which cause common allergy symptoms like tissue swelling and inflammation.

5 Aug 2024

Exploring Drug Repurposing For Arboviral Infections Through Cavitomix

The CavitOmiX drug discovery method, developed by the drug and enzyme discovery platform Innophore.

2 Aug 2024

Neuropeptides Revealed as Key Messengers in Fear Response

Researchers at Salk developed techniques to examine neuropeptides, which are messenger proteins in the brain that regulate the fear response in mice.

23 Jul 2024

Neuregulin 3 Gene Variant Linked to Gabapentin Effectiveness in Chronic Pelvic Pain

Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows.

16 Jul 2024

New Cold-Sensing Protein Discovery Could Revolutionize Pain Management

The only available treatments for millions of people with chronic pain worldwide frequently involve the use of opioids, which pose the risk of addiction and overdose.

24 Jun 2024

Human Antibodies Offer Hope for Improved Black Widow Antivenom

Sera produced from horses can be used to treat serious illnesses caused by black widow bites. But this approach is not totally secure. To address this, scientists have produced entirely human antibodies that are capable of neutralizing the European black widow's alpha-latrotoxin.

13 Jun 2024

Super-Cooled Brain Cell Molecules Shed Light on Epilepsy Drug Action

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius -; nearly twice as cold as the coldest places in Antarctica -; scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

11 Jun 2024