Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Leishmania Parasites Found to Infect Non-Immune Cells

The organisms that cause visceral leishmaniasis, a potentially deadly version of the parasitic disease that most often affects the skin to cause disfiguring disease, appear to have a secret weapon, new research suggests: They can infect non-immune cells and persist in those uncommon environments.

4 Oct 2023

Pre-Targeted Radioimmunotherapy System Cures Fatal Ovarian Cancer in Preclinical Study

A new 225Ac-DOTA-based pre-targeted radioimmunotherapy (PRIT) system has been shown to cure a highly lethal form of advanced intraperitoneal ovarian cancer in a preclinical setting with minimal side effects.

19 Sep 2023

Genomic Surveillance Finds Malaria-Causing Parasites Resistant to Treatments

Scientists have discovered new strains of malaria-causing parasites in Ethiopia that are both resistant to current treatments and evade detection by common diagnostic tests—a development that could increase malaria cases and deaths while making eradicating the disease even more difficult.

12 Sep 2023

T Cells Infiltrate Brain and Worsen Alzheimer's Pathology, Study Finds

Cognitive decline associated with Alzheimer's disease (AD) develops when neurons begin to die, which can be caused by inappropriate immune responses and excessive inflammation in the brain triggered by amyloid beta deposits and tau tangles, two hallmarks of the disease.

28 Aug 2023

Direct-to-Consumer Blood Test for Assessing User’s Alzheimer’s Disease Risk

In July, the first direct-to-consumer blood test designed to assess a user’s risk for developing Alzheimer’s disease hit the market. The test, which has not undergone Food and Drug Administration (FDA) review, measures the level of a protein called beta amyloid, a key component of plaques that form in the brains of Alzheimer’s disease patients, disrupting brain function.

23 Aug 2023

Schizophrenia-Linked Chromosome Deletion Affects Mitochondria

Investigators are learning more about how schizophrenia develops by investigating the most powerful known genetic risk factor.

22 Aug 2023

The Prevalence of Fibrinogen Aα-Chain Amyloidosis in Japanese Squirrels

Fibrinogen Aα-chain amyloidosis, a condition previously unknown in animals other than humans, has been shown to be extremely common in Japanese squirrels (Sciurus lis), according to a study conducted by Dr Tomoaki Murakami of the Tokyo University of Agriculture and Technology.

21 Aug 2023

Targeting Long-read RNA Sequencing with Low-Cost Technology

Researchers at the Children’s Hospital of Philadelphia (CHOP) have created a flexible and affordable approach for targeted sequencing of full-length RNA molecules, which might hasten the development of novel diagnostics and therapies.

16 Aug 2023

Study Links Adenovirus Infection With a Rare Blood Clotting Disorder

Platelets, or thrombocytes, are specialized cellular fragments that form blood clots when we get scrapes and traumatic injuries. Viral infections, autoimmune disease, and other conditions can cause platelet levels to drop throughout the body, termed thrombocytopenia.

11 Aug 2023

The “Unknome” Dataset Contains Protein Sequences That Are Still Unknown

Researchers from the UK anticipate that a new, freely accessible database they have developed will get smaller rather than bigger over time. This is due to the fact that it is a compilation of the many understudied proteins that are encoded by genes in the human genome, whose existence is recognized but whose activities are mostly unknown.

9 Aug 2023

Researchers Find New Way to Defeat Gray Mold Without Toxic Chemicals

It's a mold that causes billions in crop losses every year, infecting berries, tomatoes and most other fruits and vegetables.

9 Aug 2023

New Insights Into How T Cells Become Exhausted in Cancer

Immune system T cells that should be able to kill cancer cells become dysfunctional or "exhausted" within hours of encountering a tumor, according to a study reported Aug. 3 in Nature Immunology.

7 Aug 2023

New Way to Defeat the Gray Mold Without Showering Toxic Chemicals

It's a mold that causes billions in crop losses every year, infecting berries, tomatoes and most other fruits and vegetables. Now, researchers have found a way to defeat the mold without showering toxic chemicals on the crops.

4 Aug 2023

AMP Releases CYP3A4 and CYP3A5 Genotyping Assay Recommendations

The Association for Molecular Pathology (AMP), the world’s leading professional society for molecular diagnostics, released consensus recommendations today to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, encourage standardization of testing across labs, and better patient care.

11 Jul 2023

USDA Funds Texas A&M AgriLife Research to Develop “Holy Grail” of Tomatoes

The U.S. Department of Agriculture has funded a new Texas A&M AgriLife Research project expected to bring researchers even closer to developing the "holy grail" of tomatoes.

7 Jul 2023

Novel Peptide may be Key to Understanding Skin Aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "A novel peptide 'T14' reflects age and photo-aging in human skin."

6 Jul 2023

Analyzing the Role of Pyroptosis in Improving the Treatment of Lung Cancer

Lung cancer, one of the most aggressive forms of cancer, continues to be a leading cause of death worldwide. Although several new therapies have been developed for this disease, it has a poor prognosis in its advanced stages.

29 Jun 2023

Discovering a Major Factor Causing Aggressive Cancer

Researchers from the University of Otago have identified a crucial factor that contributes to the aggressive spread of colon cancer, marking a significant advancement in the fight against fatal tumors.

27 Jun 2023

Review: Role of Alternative Splicing Defects in Major Neurodegenerative Diseases

Alternative splicing, a clever way a cell generates many different variations of messenger RNAs -; single-stranded RNAs involved in protein synthesis -; and proteins from the same stretch of DNA, plays an important role in molecular biology.

21 Jun 2023

Understanding How Genes Predispose Humans to Allergies

New research is expanding the scientific understanding of why some people are more allergic than others. Researchers at the University of Pennsylvania’s Perelman School of Medicine discovered how genetic changes that modify a specific protein called ETS1 can affect our body’s response to allergens.

16 Jun 2023