Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

A Novel Regulator of RNA Processing in Alzheimer's Disease

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies the process of protein synthesis and impacts RNA processing in Alzheimer's patients' brains.

21 Oct 2024

Human Stem Cell-Derived Retinal Organoid Sheets Close Macular Holes

Researchers reported in the journal Stem Cell Reports that retinal holes in a monkey model were successfully healed by transplanting human stem cells. Following transplantation, retinal tissue was continuously added to the macular holes to seal them.

4 Oct 2024

New Insights into the Epigenetic Hallmarks of Cancer

Cancer mortality has just surpassed cardiovascular disease for the first time ever and one in two men, and one in three women, will be diagnosed with some form of the disease in the US, according to the NIH.

3 Oct 2024

Study Finds How Plants Limit Viral Spread to Progeny with RNA Interference

Scientists have learned how plants keep viruses from being passed to their offspring, a finding that could ensure healthier crops.

20 Sep 2024

Breakthrough Discovery on How TGF-Beta Communicates in Cells

Scientists discover how TGF-Beta, a crucial protein in development and cancer, sends its message even while tethered to the cell membrane.

17 Sep 2024

CHIEF Model Transforms Cancer Evaluation with Enhanced Generalizability Across Diverse Histopathology Samples

The CHIEF model revolutionizes cancer diagnosis, leveraging histopathological imaging to predict tumor origins and survival outcomes with exceptional accuracy.

16 Sep 2024

New Protein Identified in Ferns Reveals Role in Plant Gender and Stem Cell Control

Purdue University plant scientists have identified a protein that plays a previously unknown role in controlling cell differentiation and determining gender in vascular plants, using a fern model.

13 Sep 2024

Microbiotica Secures Approvals to Begin Clinical Studies in EU and UK for New Microbiome Medicines

Microbiotica, a biopharma company developing a pipeline of oral precision microbiome medicines called live biotherapeutic products (LBPs), is pleased to announce that it has received regulatory approvals to initiate clinical studies for its first two programmes in advanced melanoma (MELODY-1) and ulcerative colitis (COMPOSER-1) in selected EU countries and the UK. Both studies are due to start shortly, with initial data readouts expected by the end of 2025.

30 Aug 2024

Single-Cell RNA Sequencing Reveals Cellular Changes in Early Alzheimer's Disease

An analysis of more than 1.6 million brain cells from older adults has captured the cellular changes that occur in the early stages of Alzheimer's disease, potentially revealing new routes for preventing the most common cause of dementia in older individuals.

29 Aug 2024

RNA Interference Drugs Offer Faster, More Effective Alternative to Traditional Drug Discovery

Alnylam's RNA interference platform accelerates drug discovery by targeting RNA transcripts, addressing complex diseases with innovative therapeutic strategies.

28 Aug 2024

The Complex Link Between DNA Modification and ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which remains incurable. The disease is characterized by the selective degeneration of upper motor neurons in the motor cortex as well as the lower motor neurons in the brainstem and spinal cord. The cause of ALS remains unknown in 90 percent of cases, which are referred to as sporadic ALS because there is no family history for the disease. Cumulative evidence suggests that sporadic ALS may result from complex interactions between genetic susceptibility and aging.

23 Aug 2024

UChicago Team Secures $7.4 Million Grant to Study Cellular Adaptation

Cells use a variety of processes to adapt to changes and stressors in their environment, like increased temperature.

21 Aug 2024

New Imaging Technique Offers Clearer View of Brain Function

Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution. By imaging much faster and with less harm to brain tissue than traditional two-photon microscopy, the new approach could provide a clearer view of how neurons communicate in real time, leading to new insights into brain function and neurological diseases.

16 Aug 2024

Lipid Accumulation Linked to Senescence in Dopaminergic Neurons

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."

14 Aug 2024

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells. The findings, made in mice, were published today in the journal Science.

9 Aug 2024

Genetic Analysis of Potato and Phytophthora infestans During and After the Irish Potato Famine

In an examination of the genetic material found in historic potato leaves, North Carolina State University researchers reveal more about the tit-for-tat evolutionary changes occurring in both potato plants and the pathogen that caused the 1840s Irish potato famine.

6 Aug 2024

Pathology News and Research

A Novel Regulator of RNA Processing in Alzheimer's Disease

Human Stem Cell-Derived Retinal Organoid Sheets Close Macular Holes

New Insights into the Epigenetic Hallmarks of Cancer

Study Finds How Plants Limit Viral Spread to Progeny with RNA Interference

Breakthrough Discovery on How TGF-Beta Communicates in Cells

CHIEF Model Transforms Cancer Evaluation with Enhanced Generalizability Across Diverse Histopathology Samples

New Protein Identified in Ferns Reveals Role in Plant Gender and Stem Cell Control

Microbiotica Secures Approvals to Begin Clinical Studies in EU and UK for New Microbiome Medicines

Single-Cell RNA Sequencing Reveals Cellular Changes in Early Alzheimer's Disease

RNA Interference Drugs Offer Faster, More Effective Alternative to Traditional Drug Discovery

The Complex Link Between DNA Modification and ALS

UChicago Team Secures $7.4 Million Grant to Study Cellular Adaptation

New Imaging Technique Offers Clearer View of Brain Function

Lipid Accumulation Linked to Senescence in Dopaminergic Neurons

Research Unlocks Secrets of Stem Cell Retention in Bone Marrow

Genetic Analysis of Potato and Phytophthora infestans During and After the Irish Potato Famine

Study Challenges Current Understanding of Parkinson's and Lewy Body Disease Onset

Rapid Parkinson's Model Opens Door to Personalized Treatments

IL-22BP Protein's Influence on Gut Microbiota and Infection Response Revealed

Innovative Model Creates Personalized Parkinson's Disease Brain Cells for Drug Testing

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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