Pathophysiology News and Research

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Novel protein biomarker panel can detect Parkinson's disease in early stages using blood samples

A team of researchers used multiplexed mass spectrometry data and a machine learning model to identify biomarkers that can predict Parkinson’s disease.

27 Jun 2024

Remote ischemic conditioning:A potential treatment option for necrotizing enterocolitis

Necrotizing enterocolitis is a life-threatening neonatal disease with high morbidity and mortality rates.

21 May 2024

Breaking Down the Complex Mechanisms of Neurodegeneration

By using a novel neuronal cell culture model, researchers at the University of Zurich have illuminated the complex mechanisms behind neurodegeneration.

23 Feb 2024

The Prevalence of Fibrinogen Aα-Chain Amyloidosis in Japanese Squirrels

Fibrinogen Aα-chain amyloidosis, a condition previously unknown in animals other than humans, has been shown to be extremely common in Japanese squirrels (Sciurus lis), according to a study conducted by Dr Tomoaki Murakami of the Tokyo University of Agriculture and Technology.

21 Aug 2023

Study Shows How Sensory Neurons Control Gastrointestinal Tracts

Gastrointestinal and digestive issues impact roughly 3 million people across the United States alone, and that number is growing.

4 Aug 2023

The Association Between Type 2 Diabetes Treatment Response and Genetic Variants

People who are at a high risk of developing type 2 diabetes can be prescribed a variety of medications to decrease blood sugar levels, but it is not always apparent which people would benefit from which treatments the most.

6 Jun 2023

Machine Learning Reveals Sex-Specific Genes, Molecular Pathways Linked to Alzheimer's Disease Progression

Alzheimer's Disease (AD) is a complex neurodegenerative illness with genetic and environmental origins.

22 May 2023

Low protein synthesis in humans causes rare intestinal disease

According to a recent study, which will be published on November 1st, 2022, by Yun-Fei Li of Zhejiang University School of Medicine in Hangzhou, China, and colleagues, a decrease in protein synthesis in growing gut cells contributes to a rare genetic condition, and an affordable nutritional supplement could help reverse that decrease.

3 Nov 2022

Rare and protective loss-of-function mutations offer possible NAFLD drug targets

A significant genome-wide association study on the nonalcoholic fatty liver disease (NAFLD) has just been published in Nature Genetics by researchers from Amgen subsidiary deCODE Genetics.

26 Oct 2022

Scientists decipher a direct dialog between the gut microbiota and the brain

Gut microbiota by-products circulate in the bloodstream, regulating host physiological processes including immunity, metabolism and brain functions.

From Institut Pasteur 18 Apr 2022

HIF-1alpha inhibitor preserves the activity of insulin-producing beta cells in diabetic mice

High blood glucose is responsible for several complications in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden have identified a new antidiabetic substance that preserves the activity of insulin-producing beta cells and prevents high blood glucose in mice.

31 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

8 Mar 2022

Largest genome study identifies new genetic risk factors for migraine

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

4 Feb 2022

Scientists discover new genetic link to non-alcoholic inflammatory liver disease

Non-alcoholic fatty liver disease (NAFLD) is the accumulation of fat in the liver unrelated to alcohol abuse or other liver diseases.

11 Nov 2021

Study identifies a novel role for regulatory protein Bach1 in Parkinson's disease

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, afflicting more than 10 million people worldwide and more than one million Americans. While there is no cure for PD, current therapies focus on treating motor symptoms and fail to reverse, or even address, the underlying neurological damage.

26 Oct 2021

Pathophysiology News and Research

Novel protein biomarker panel can detect Parkinson's disease in early stages using blood samples

Remote ischemic conditioning:A potential treatment option for necrotizing enterocolitis

Breaking Down the Complex Mechanisms of Neurodegeneration

The Prevalence of Fibrinogen Aα-Chain Amyloidosis in Japanese Squirrels

Study Shows How Sensory Neurons Control Gastrointestinal Tracts

The Association Between Type 2 Diabetes Treatment Response and Genetic Variants

Machine Learning Reveals Sex-Specific Genes, Molecular Pathways Linked to Alzheimer's Disease Progression

Low protein synthesis in humans causes rare intestinal disease

Rare and protective loss-of-function mutations offer possible NAFLD drug targets

Scientists decipher a direct dialog between the gut microbiota and the brain

HIF-1alpha inhibitor preserves the activity of insulin-producing beta cells in diabetic mice

New database provides extensive information on kinase-associated neural protein phosphorylation

Study takes a deep dive into the molecular biology of the brain in bipolar disorder patients

Largest genome study identifies new genetic risk factors for migraine

Scientists discover new genetic link to non-alcoholic inflammatory liver disease

Study identifies a novel role for regulatory protein Bach1 in Parkinson's disease

Neuroinflammation protein associated with sex-specific survival differences in glioblastoma patients

Bacteria-derived curli amyloid fibril promotes neurodegeneration in the host

Metabolite produced by gut microbes found to be involved in regulating commensal bacteria

Researchers identify a novel pathomechanism leading to Usher syndrome

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Expert Insights: HiMedia Labs on Advancing Nucleic Acid Extraction Across Industries

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