Pharmacology News and Research

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Pharmacology is the study of how chemical substances interact with living systems. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, interactions, toxicology, therapy, and medical applications and antipathogenic capabilities.

MAGE Technology Helps Reveal the Potency of Antibiotics

By substituting each of the 20 amino acid alternatives found in nature for one of the 38 amino acid components that make up the rifampicin binding site on E. coli, the study authors were able to produce 760 distinct RNAP mutants. The development of this mutant pool was then examined under various circumstances, including rifampicin therapy.

31 Aug 2023

Discovery on Learning and Memory Could Lead to New Alzheimer's Treatments

Scientists at the University of Colorado Anschutz Medical Campus have made a `paradigm shifting’ discovery on the mechanisms required for learning and memory that could lead to new therapies for Alzheimer’s disease and potentially Down syndrome.

31 Aug 2023

Age-Related Hearing Loss Associated With Decrease of Cholesterol in the Inner Ear

Researchers led by María Eugenia Gomez-Casati, the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET; Mauricio Martin, the Institute of Medical Research Mercedes; and Martín Ferreyra, (INIMEC-CONICET-UNC), National University of Córdoba in Argentina report that age-related hearing loss is associated with a decrease of cholesterol in the inner ear.

25 Aug 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Identifying The Best Antibodies Using X-Rays

Imagine you're going to a party where you only know a single person. While you've been friends with this person for a long time, you're concerned about them leaving you alone in a room full of strangers. Even though they promise they'll stick by your side, they immediately walk away from you upon entering the party to speak to someone else they know.

26 Jul 2023

New Process by Which Enzymes Help Prevent Heart Damage in Chemotherapy Patients Identified

Researchers at the University of Illinois Chicago have identified a process by which enzymes can help prevent heart damage in chemotherapy patients.

21 Jul 2023

Researchers Make Breakthrough in Fight Against Familial Hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world.

21 Jul 2023

AI-Powered Collaboration Aims to Transform Drug Development

Critical Path Institute (C-Path), a leading global nonprofit committed to expediting drug development through the acceleration of regulatory-endorsed solutions, today announced a newly formalized Memorandum of Understanding (MOU) with Vivpro, an industry-leading provider of a revolutionary biointelligence software platform and innovative services.

14 Jul 2023

Revealing the Function of Retrotransposons

A retrotransposon, a parasitic DNA sequence that borrows the cell’s own machinery to accomplish its objectives, has been discovered.

13 Jul 2023

The Future of Nanobiotechnology: Ethical Considerations

Prosthetics moved by thoughts. Targeted treatments for aggressive brain cancer. Soldiers with enhanced vision or bionic ears.

13 Jul 2023

AMP Releases CYP3A4 and CYP3A5 Genotyping Assay Recommendations

The Association for Molecular Pathology (AMP), the world’s leading professional society for molecular diagnostics, released consensus recommendations today to aid in the design and validation of clinical CYP3A4 and CYP3A5 genotyping assays, encourage standardization of testing across labs, and better patient care.

11 Jul 2023

Elaborate 3D Structures of DNA That Mimics Protein Functions

According to a study from scientists at Weill Cornell Medicine and the National Heart, Lung, and Blood Institute, a division of the National Institutes of Health, DNA can imitate protein activities by folding into complex, three-dimensional structures.

22 Jun 2023

Metrion Biosciences Appoints Dr Steve Jenkinson as VP, Drug Discovery and Safety Assessment to Strengthen US Operations

Metrion Biosciences Ltd (“Metrion”), the specialist ion channel contract research and drug discovery company, today announced the appointment of Dr Steve Jenkinson as Vice President, Drug Discovery and Safety Assessment.

12 Jun 2023

Combining Proteins With Nano-Based Engineering to Create Circuits

Penn State researchers have developed the first protein-based nano-computing agent that can be used as a circuit.

29 May 2023

How the Disturbed Recycling Chain of Endoplasmic Reticulum Causes Neurodegenerative Diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

29 May 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Study Provides a New Picture of How Bacterial Cells Repair Faulty DNA

A new study adds to an emerging, radically new picture of how bacterial cells continually repair faulty sections of their DNA.

17 May 2023

Discovery of Shanghai APP Mutation Offers New Avenues for Treatment of Alzheimer's Disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting tens of millions of people worldwide, and it is the most common cause of dementia.

15 May 2023

Manipulating Brain Cells via Light Irradiation

An international research team, comprising scientists from DZNE, University Hospital Bonn, the Netherlands, and the US has been awarded a US$ 1.3 million grant by the "Human Frontier Science Program" to investigate brain immune cells and manipulate them via light irradiation.

8 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023