Pharmacology News and Research

RSS

Pharmacology is the study of how chemical substances interact with living systems. If substances have medicinal properties, they are considered pharmaceuticals. The field encompasses drug composition and properties, interactions, toxicology, therapy, and medical applications and antipathogenic capabilities.

Bacterial Protein Utilizes DNA for Target Recognition and Plasmid Elimination

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

30 Aug 2024

Cryo-EM Study Sheds Light on HSV Drug Resistance Mechanisms Through Protein Movement

All organisms -; from fungi to mammals -; have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with an ability to mutate greater than any other organism. As a result, they can evade treatments or acquire resistance to once-effective antiviral medications.

28 Aug 2024

Ginseng Genome Map Unlocks New Possibilities for Medicinal Applications

A landmark study has successfully decoded the complete ginseng genome, unveiling the genetic mechanisms that govern saponin biosynthesis. This detailed genetic map illuminates the evolutionary and metabolic pathways of Panax ginseng, a staple in traditional medicine.

19 Jul 2024

FAM110A's Dual Role: Orchestrating Microtubule-Actin Interactions in Mitosis

An international research collaboration, led by Prof. Dr. Robert Grosse (Centre for Integrative Biological Signalling Studies and Institute of Clinical and Experimental Pharmacology and Toxicology, University of Freiburg), Dr. Libor Macurek (Institute of Molecular Genetics, Czech Academy of Sciences, Prague) and Dr. Zdenek Lansky (Institute of Biotechnology, Czech Academy of Sciences, Prague) has uncovered a new mechanism of the crosstalk between microtubules and actin cytoskeleton during cell division and revealed unique characteristics of the previously unexplored protein FAM110A.

17 Jul 2024

The Protein STAT3 Helps the Immune System Fight Leukemia

Study at the Karl Landsteiner University of Health Sciences uncovers unknown interaction between leukemic cells and immune cells. Potential biomarkers for future immunotherapies found.

From Karl Landsteiner University of Health Sciences 17 Jul 2024

Surface Plasmon Resonance Sensors: Transforming Drug Development and Clinical Diagnostics

The latest developments in SPR-based biosensors and their applications in drug discovery.

15 Jul 2024

UCL Study Uncovers Astrocytes' Role in Brain Energy Boosting Mechanism

A key mechanism which detects when the brain needs an additional energy boost to support its activity has been identified in a study in mice and cells led by UCL scientists.

4 Jul 2024

Study Uncovers a Biological Explanation for Long-Term Memories

Whether it's a first-time visit to a zoo or when we learned to ride a bicycle, we have memories from our childhoods kept well into adult years.

27 Jun 2024

Synthetic Anti-Clotting Agent Derived from Bloodsucking Organisms Saliva

Ticks, mosquitoes, and leeches are endowed by nature with a rapid method of preventing blood clotting while they feed on their host.

14 May 2024

New Insights Into PARP1 Biology Could Open Avenues to Improve Cancer Treatments

A new study led by University of Pittsburgh and UPMC Hillman Cancer Center researchers shows that an enzyme called PARP1 is involved in repair of telomeres, the lengths of DNA that protect the tips of chromosomes, and that impairing this process can lead to telomere shortening and genomic instability that can cause cancer.

8 May 2024

New Method Sheds Light on How Protein Modifications Power T Cells

Imagine riding a bike. Now imagine riding a bike with an enormous beach ball stuck on your handlebars. That "modification" might change your experience quite a bit.

30 Apr 2024

Study Reveals Molecular Assembly of One of the Most Common Anti-Phage Systems

One of the many secrets to bacteria's success is their ability to defend themselves from viruses, called phages, that infect bacteria and use their cellular machinery to make copies of themselves.

29 Apr 2024

New Study Discovers Gene Associated with Epilepsy and Autism

A genetic mutation or variation in the SCN2A gene is known to cause infantile seizures, autism spectrum disorder, and intellectual disability, among other moderate-to-severe impairments in movement, communication, feeding, and vision.

29 Apr 2024

Study Unravels How Tumors Evade Immune Response by Targeting T Cells

Tumors actively prevent the formation of immune responses by so-called cytotoxic T cells, which are essential in combating cancer.

25 Apr 2024

Study Uncovers Cells' Surprising Strategy to Control Signaling Pathways

Healthy cells respond appropriately to changes in their environment. They do this by sensing what's happening outside and relaying a command to the precise biomolecule in the precise domain that can carry out the necessary response.

23 Apr 2024

Blessed Thistle Compound Shows Promise in Nerve Repair

Cnicin, a compound found in Blessed Thistle (Cnicus benedictus), significantly accelerates axon growth in human and animal models.

22 Apr 2024

Unraveling the Molecular Mechanisms of DNA Entanglement Resolution

Picture in your mind a traditional "landline" telephone with a coiled cord connecting the handset to the phone.

12 Apr 2024

Acidic Fortress of Tumors Could Rebuff Immune Cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

2 Apr 2024

Nanoparticle-Based Therapy Shows Promise in Eradicating Tumors

A nanoparticle-based therapy developed by UT Southwestern Medical Center scientists stimulated an immune pathway that eradicated tumors in mouse models of various cancer types.

28 Mar 2024

Nature-Inspired Approach Accelerates Folding of Cysteine-Rich Peptides for Drug Discovery

Certain types of peptides and microproteins for drug discovery research can be made more efficiently and quickly using a reaction solvent that helps mimic nature's way.

25 Mar 2024