Blessed Thistle Compound Shows Promise in Nerve Repair

Cnicin, a compound found in Blessed Thistle (Cnicus benedictus), significantly accelerates axon growth in human and animal models. This research, led by Dr. Philipp Gobrecht and Professor Dr. Dietmar Fischer at the University of Cologne, opens a new avenue for potential nerve regeneration treatments. The findings are published in Phytomedicine.

Rapid Help for Nerves

In humans and other animals with long axons, damaged nerves' regeneration pathways are also long. Because the axons cannot reach their destination in time, this frequently results in a lengthy and sometimes irreversible healing process. Hence, an accelerated regeneration growth rate can play a significant role in this situation by guaranteeing that the fibers arrive at their original location on schedule and preventing the occurrence of irreversible functional deficits.

Using human cells obtained from patient-donated retinae, as well as animal models, the researchers were able to demonstrate axon regeneration. Giving mice or rats a daily dose of Clinipin aided in the rapid improvement of paralysis and neuropathy.

Cnicin has one very important advantage over other compounds: it can be ingested (by mouth) and enter the bloodstream. It is not required to be administered via injection.

The correct dose is very important here, as Cnicin only works within a specific therapeutic window. Doses that are too low or too high are ineffective. This is why further clinical studies on humans are crucial.

Dr. Dietmar Fischer, Study, University of Cologne

Researchers at the University of Cologne are currently organizing pertinent investigations. Drugs to restore the damaged nervous system are being researched and developed by the Center for Pharmacology.

Journal reference:

Gobrecht, P., et al. (2024) Cnicin promotes functional nerve regeneration. Phytomedicine.        


The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of AZoLifeSciences.
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