Pluripotency News and Research

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New Platform Reveals Individual Sensitivity to Disease-Causing Mutations

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

4 Apr 2024

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

DNA Aptamer Promotes Cardiomyocyte Differentiation From Pluripotent Stem Cells

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

12 Oct 2023

Towards A Better Understanding of Early Human Embryonic Development

Despite being an essential developmental process, the understanding of human embryonic genome activation is limited, owing to the lack of in vitro cell models and ethical concerns.

22 Sep 2023

Characterizing a Pivotal Time in Mammalian Embryonic Development

Many of life’s secrets are hidden in the initial stages of embryonic development. Unraveling these mysteries can aid in the understanding of early development and birth abnormalities, as well as the creation of innovative regenerative medicine treatments.

31 May 2023

How Epigenetic Landscape Impacts Pioneer Transcription Factor Binding

St. Jude Children’s Research Hospital researchers are investigating how a type of transcription factor known as a pioneer transcription factor reaches DNA even when it is tightly wrapped.

25 May 2023

Cedars-Sinai and Axiom Space of Houston Collaborate to Send Stem Cells to Space

Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.

18 Apr 2023

The Modified Development Potential of Worm Embryonic Cells

A startling discovery that challenges the conventional wisdom that the majority of the hereditary information for cell differentiation is encoded within DNA and other genetic factors has been made regarding how specific proteins within the chromosomes of roundworms facilitate their offspring to develop specialized cells generations later.

10 Apr 2023

New guidelines to generate high-quality, well-structured organoids

Researchers have opened a new avenue for investigations of neurological development, disease, and therapies that cannot be undertaken in living people by employing stem cells to grow small brain-like structures in the lab.

30 Sep 2022

Key regulator of cell differentiation discovered

Embryonic stem cells and other pluripotent cells divide rapidly and have the capacity to become nearly any cell type in the body.

22 Feb 2022

Researchers elucidate how early embryo cells begin to independently produce proteins

It happens in the first hours after fertilization: The cells of the early embryo begin to independently produce proteins, the building blocks for cells and organs.

16 Feb 2022

Study findings greatly expand the ability to engineer long-range genome edits

Researchers discovered the potential of CRISPR, a tool used by bacteria to defend themselves against viral intruders, nearly a decade ago.

24 Jan 2022

Key networks controlling pluripotency and apoptosis during development revealed

During the early stages of human embryonic development, a small collection of cells called human embryonic stem cells co-ordinates growth and differentiation finally giving rise to highly specialized human tissues.

1 Nov 2021

Novel mechanism sheds light on embryonic stem cell pluripotency

A group of scientists from Sweden recently pinpointed a cellular mechanism that is vital for the ability of these cells to remain as stem cells.

7 Oct 2021

Cryopreservation Excipient for Cell Therapies

AMSBIO has launched STEM-CELLBANKER® EX - a next generation cryopreservation product that eliminates the need for the traditional washing steps required in cell therapy product development.

From AMS Biotechnology 10 Sep 2021

Chemical fingerprints help assess the reprogramming of regular cells into stem cells

The Nobel Prize-winning revelation that ordinary cells might be induced to revert to their earliest pluripotent state heralded the start of the ethical stem cell era.

28 Jun 2021

Study reveals molecular mechanisms involved in the maintenance of naïve embryonic stem cells

Researchers have explained mechanisms that play a role in maintaining the embryonic stem cells in the most optimized state for use in regenerative medicine.

26 Mar 2021

Study outlines transient prospective stages in development of neural crest cells

Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos.

19 Nov 2020

Study reveals proteins that enable SINEUPs to increase protein production

Scientists from an international group led by the RIKEN Center for Integrative Medical Sciences and Yokohama City University have discovered that a pair of proteins play a key role in allowing an important type of functional non-coding RNA, known as SINEUPs, to act to promote their target messenger RNA.

2 Nov 2020