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New technology efficiently delivers immune checkpoint inhibitors for treating brain tumors

Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.

12 Oct 2021

Common drug to treat cancer reverses Alzheimer’s symptoms in mice

A drug commonly used to treat cancer can restore memory and cognitive function in mice that display symptoms of Alzheimer's disease, new UBC research has found.

6 Oct 2021

Study pinpoints means to restore the efficacy of drugs for acute myeloid leukemia

Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.

1 Oct 2021

Intermittent fasting slows aging and increases longevity in fruit flies, study shows

Whether intermittent fasting is called the 5:2 diet or the 16/8 method, celebrities swear that these eating regimens are a great way to lose weight. Fasting is now trendy, but real science backs up claims that fasting two days a week or restricting eating to an eight-hour window each day leads to weight loss.

30 Sep 2021

Novel process enables 3D imaging of human organs with micrometer resolution

Scientists recently demonstrated a process by which specific cell types in human organs can be investigated with micrometer precision.

15 Sep 2021

Pairing microscopy with AI to develop a rapid, accurate COVID-19 test

Beckman researchers paired microscopy with artificial intelligence to develop a COVID-19 test that's fast, accurate, and cost-effective. All we need to do is say "ahh."

13 Sep 2021

Family of naturally occurring proteins shows promise for treating ischemic stroke

Boosting a family of naturally occurring proteins that dampens inflammation in the body has been shown to be effective in reducing damage from an ischemic stroke, according to preclinical researchers at The University of Texas Health Science Center at Houston.

2 Sep 2021

Researchers pinpoint a lack of best practices in mammalian cell culture

A group of KAUST researchers and co-workers in Saudi Arabia and the United States examined 810 randomly selected papers on mammalian cell lines.

16 Aug 2021

Medicines Discovery Catapult relaunches Wolfson Radiochemistry facility in Manchester

Medicines Discovery Catapult (MDC) today announces the relaunch of radiochemistry at the Wolfson Molecular Imaging Centre (WMIC) in Manchester.

5 Aug 2021

New formulation to administer antibodies for choroidal neovascularization therapy

Scientists have created a new formulation based on regulatory T-cell exosomes (rEXS) to administer vascular endothelial growth factor (VEGF) antibodies.

28 Jul 2021

Modification in some RNA molecules could protect against non-alcoholic fatty liver

RNA molecules while carrying genetic instructions from DNA to the protein-making machinery of cells could help guard against non-alcoholic fatty liver.

21 Jul 2021

Researchers use body-on-a-chip cancer models to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

20 Jul 2021

Genetically engineering NK cells can target and kill glioblastoma stem cells

Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity.

18 Jun 2021

Novel platform may lead to more improved gene therapies

Researchers from RCSI University of Medicine and Health Sciences have developed polypeptide-based materials that serve as effective vectors in delivering gene therapies.

11 Jun 2021

Commonly used antidepressant drugs can also help the immune system to attack cancer

A class of drug called monoamine oxidase inhibitors is commonly prescribed to treat depression; the medications work by boosting levels of serotonin, the brain's "happiness hormone."

10 Jun 2021

Gene therapy may be a safe and effective single-dose treatment for hypophosphatasia

A preclinical study led by scientists at Sanford Burnham Prebys has established that AAV8-TNAP-D10--a gene therapy that replaces a key enzyme found in bone--may be a safe and effective single-dose treatment for hypophosphatasia (HPP).

8 Jun 2021

Study discovers novel function for metabolic enzyme medium-chain acyl-CoA dehydrogenase

Scientists have come up with an innovative function for the metabolic enzyme medium-chain acyl-CoA dehydrogenase (MCAD) in glioblastoma (GBM).

1 Jun 2021

More informed choices of contraceptives can prevent breast cancer

Hormonal contraceptives, e.g. the pill, the patch, and the vaginal ring, contain synthetic hormones that prevent pregnancy by either stopping ovulation, changing the cervical mucus to stop sperm from passing through the cervix and finding an egg, or changing the womb's lining to prevent a fertilized egg from being implanted in it.

31 May 2021

Latest articles provide novel insights into the mechanisms driving pridopidine neuroprotective effects

Prilenia Therapeutics B.V., a clinical stage biotech company focused on developing novel treatments for neurodegenerative and neurodevelopmental disorders, today announces the publication of three peer-reviewed journal articles, highlighting key aspects of the mechanism of action of its lead asset, pridopidine, and the importance of S1R activation as a mechanism to attenuate biological features of neurodegenerative diseases.

25 May 2021

Gene expression signatures underlying microglia linked with amyloid plaque phagocytosis

Alzheimer’s disease is the most prevalent form of dementia distinguished by the accumulation of amyloid plaques in the brain.

24 May 2021