Preclinical News and Research

RSS

Mapping Gene Signatures Unveils How Lewy Bodies Impact Brain Cells

A new study by scientists at Van Andel Institute provides an initial glimpse into the intricate molecular changes taking place in brain cells with Lewy bodies, crucial pathological markers of Parkinson’s disease and certain dementias.

17 Apr 2024

Understanding Prostate Cancer Disparities Through Proteogenomics

Certain proteogenomic signatures in the prostate cancers of men of African and European ancestries were associated with higher risk of metastasis and/or recurrence of the disease, according to a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2024, held April 5-10.

10 Apr 2024

TAM-Sense Offers Painless Imaging of Tumor Inflammation

The National Institutes of Health (NIH) has awarded two new grants totaling $6.7 million to researchers at the University of California San Diego School of Medicine.

2 Apr 2024

Bioinformatics Tool Recognizes Chromosome Changes in Cancer Cells

A group from IRB Barcelona and the University of Barcelona has created a novel bioinformatics instrument to recognize the chromosomal changes characteristic of cancerous cells.

22 Mar 2024

Latest CRISPR-Cas Gene Editing Can Eliminate All Traces of HIV Virus From Infected Cells

New research presented early ahead of this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2024, Barcelona, 27-30 April) from a team of researchers in the Netherlands shows how the latest CRISPR-Cas gene editing technology can be used to eliminate all traces of the HIV virus from infected cells in the laboratory, raising hopes of a cure.

20 Mar 2024

Drug Candidates Show Promise to Reverse HIV's Ability to Escape Immune System Detection

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

20 Mar 2024

New Research Sheds Light on the Evolution of Skin Appendages

The evolution of hair had a crucial role in the development of animals, including humans. However, it was previously unknown where the genetic code for hair originated in the evolutionary process.

19 Mar 2024

New Biomarker Offers Early Detection of ALS and FTD

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

19 Mar 2024

Baby Gut Bacteria Found to Play Crucial Role in Immune Development

Researchers at Weill Cornell Medicine have shown that certain bacteria invade the stomach soon after birth and produce serotonin, a neurotransmitter that helps teach gut immune cells.

18 Mar 2024

Method Seeks to Eliminate the Need for Frozen mRNA Vaccines

CEPI has provided funding to a public research university in Belgium to investigate whether a novel vaccine stabilization method could eliminate the need for mRNA vaccines to be stored in frozen storage and enable a quick and expanded response to future outbreaks in as little as 100 days.

14 Mar 2024

ELRIG UK Announces Steve Bates and Dr Anderson Ryan as Keynote Speakers at Research and Innovation 2024

The European Laboratory Research & Innovation Group (ELRIG) UK today announced the keynote speakers for its upcoming Research and Innovation conference taking place at the University of Manchester from 20–21 March.

From ELRIG (UK) Ltd. 8 Feb 2024

Diagnostic Biochips: Brain Research Tools for the Future

In this interview, we delve into the innovative world of Diagnostic Biochips with its founder, Brian Jamieson. He shares insights into the company's inception, its contributions to advancing brain research, and the future of neural interfacing technology.

1 Feb 2024

Gene Therapy Can Interrupt the Progression of Deadly Inherited Heart Condition

A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.

31 Jan 2024

Boosting Central Memory T Cells with Targeted Protein Modulation

The Hackensack Meridian Center for Discovery and Innovation's (CDI) Xue Lab has made yet another advancement in the understanding of the immune system and its potential for disease-fighting modulation.

22 Jan 2024

Traffic Jam in the Brain: Study Uncovers Cellular Cause of Rare Neurological Disease

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

22 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Human Conjunctiva Model Developed For First Time

The Hubrecht Institute's Organoid group created the first organoid model of the human conjunctiva. The function of these organoids is mimicked by the human conjunctiva, a tissue involved in the formation of tears.

12 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

Brain Cell Genetics Drive Alzheimer's Progression

Developing treatments for Alzheimer's disease (AD) is difficult because complex underlying mechanisms drive different types of cells that may contribute to the disorder.

6 Dec 2023