Proteomics News and Research

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The term 'proteome' was first coined in 1994, and refers to all the proteins in a cell, tissue, or organism. Proteomics refers to the study of the proteome. Because proteins are involved in almost all biological activities, the proteome is a rich source of biological information.

Study Identifies 39 Genetic Mutations Associated With Heart Failure

In a new study co-led by investigators at the United States Department of Veterans Affairs and Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, a global team of scientists conducted one of the largest genetic association studies on heart failure to date.

25 Aug 2023

New Collaboration Aims to Advance Cancer Therapies Against Previously Undruggable Targets

The University of Texas MD Anderson Cancer Center and Nexo Therapeutics today announced a multi-year strategic collaboration that aligns the innovative technology and capabilities of each organization at the earliest stages of drug discovery and development to rapidly advance impactful new cancer therapies against previously undruggable targets.

26 Jul 2023

Xenogeneic-Free Brain Organoids Offer New Hope for Studying Neurodegenerative Diseases

Researchers at University of Michigan developed a method to produce artificially grown miniature brains -; called human brain organoids -; free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated.

14 Jul 2023

New Method Provides Near-Perfect Control Over the Manipulation of Individual Molecules

Aleksandra Radenovic, Head of the School of Engineering’s Laboratory of Nanoscale Biology, has spent years working to enhance nanopore technology, which primarily involves a molecule like DNA through a tiny pore in a membrane to quantify an ionic current.

20 Jun 2023

The New Player in ALS—An Ancient, Virus-Like Protein

ALS (amyotrophic lateral sclerosis) is a deadly neurodegenerative disease that attacks nerve cells in the brain and spinal cord, progressively robbing individuals of their capability to speak, move, eat, and breathe.

8 Jun 2023

Novel Map Depicts the Human Body's Highly Complicated System for Repairing DNA Damage

Writing in the May 22, 2023 issue of Cell Systems, a diverse team of scientists, led by researchers at University of California San Diego School of Medicine, have produced a novel map that depicts the human body's enormously complicated and highly evolved system for addressing and repairing DNA damage -; a cause and consequence of many diseases.

23 May 2023

Proteomics Approach Identifies p62-Mediated Selective Autophagy of the Supramolecular Vault Complex

Our body functioning is delicately balanced between the synthesis and breakdown of various cellular components.

16 May 2023

Robust AI System Identifies Protein Patterns Within Individual Cells

A highly innovative artificial intelligence (AI) system identified protein patterns within individual cells with world-leading accuracy and speed.

From University of Surrey 16 May 2023

Using Mass-Spectrometry-Based Cancer Proteomics Datasets to Discover Potential Therapeutic Targets

A new research perspective was published in Oncotarget's Volume 14 on May 4, 2023, entitled, "Using cancer proteomics data to identify gene candidates for therapeutic targeting."

11 May 2023

Researchers Create a Computational Tool to Gain New Insights From Multi-Omics Data

Despite the astounding advances made in understanding the biologic underpinnings of cancer, many cancers are missing obvious genetic drivers.

5 May 2023

New Extraction Protocol Offers a More Comprehensive Picture of Cellular Activity

Researchers at the Van Andel Institute have created a new extraction protocol for RNA-seq and metabolomic analysis that provides a more comprehensive picture of cellular activity than either technique alone.

3 May 2023

Previously Unknown Regulatory Mechanism for Circadian and Temperature Signaling Pathways Revealed

Ever wondered why people become tired when the sun goes down? What causes some flower petals to open during the day and close at night? Or how monarch butterflies ascertain when to migrate south?

2 May 2023

Insights into mechanisms impacting NSCLC disease progression

Proteomics is the study and analysis of proteins in a biological system, including their structures, functions, associations, and alterations.

5 Apr 2023

Meta-scale approach to quantifying the protein variants in the human body

A key conundrum in biology is why many very simple creatures, such as the widely studied worm C. elegans, have almost as many genes as the human genome, which has about 20,000 genes.

27 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

Potential therapeutic can synergize with existing drugs to effectively destroy leukemia cells

A team of researchers has discovered a potential therapeutic that can synergize with existing drugs to more effectively kill certain leukemia cells.

9 Mar 2023

Study shows why a specific gene mutation has opposite effects on mice and human cancers

A small but significant metabolic difference between human and mouse lung tumor cells, has been discovered by Weill Cornell Medicine researchers, explaining a discrepancy in previous study results, and pointing toward new strategies for developing cancer treatments.

27 Feb 2023

Metabolic reactions upon activating Akt2 enzyme revealed

Takeaki Ozawa and his team from the University of Tokyo reveal the metabolic reactions upon activating an enzyme called Akt2.

22 Feb 2023

Analyzing the existence of unknown miniproteins

Evolutionarily young miniproteins are unique in humans, and scientists have recently found thousands of them.

21 Feb 2023

New models provide better understanding of how life originated

The first signs of life emerged on Earth in the form of microbes about four billion years ago. While scientists are still determining exactly when and how these microbes appeared, it's clear that the emergence of life is intricately intertwined with the chemical and physical characteristics of early Earth.

13 Feb 2023