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Super-resolution fluorescence microscopy offers first molecular view inside cells

Medical scientists from UNSW Sydney have successfully detected the interactions that occur between individual molecules located inside intact cells, thus achieving unparalleled resolution capabilities in single-molecule microscopy.

21 Apr 2020

Chemical tools can regulate lipid concentration in living cells

Lipids have several crucial functions in the human body: They serve as messengers, which mediate the growth of cells and regulate the release of hormones.

20 Apr 2020

Study pinpoints a key brain region for controlling binge drinking

A team of National Institutes of Health-funded researchers at the Medical University of South Carolina has found that deactivating a stress-signaling system in a brain area known for motivation and emotion-related behaviors decreases binge drinking.

20 Apr 2020

Study Reveals Bile Metabolite Of Gut Microbes Boosts Immune Cells

A study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells.

20 Apr 2020

Designing Peptide Inhibitors For Possible COVID-19 Treatments

Scientists across the globe are rushing to find inhibitors of SARS-CoV-2, the new coronavirus behind the COVID-19 pandemic.

20 Apr 2020

Specialized proteins could help combat severe cytokine storms in COVID-19 patients

One of the defining features of COVID-19 is the excessive immune response that can occur in severe cases. This burst of immune overreaction, also called a cytokine storm, damages the lungs and can be fatal.

17 Apr 2020

Synapses of the human nervous system

The glutamate receptors do not actually adhere to “distance keeping.” Now, high-resolution microscopic studies have revealed that the receptors often appear in small groups at the synapses and remain in contact with other proteins.

17 Apr 2020

UTSW researchers solve structure of key protein involved in muscle contraction

Researchers at UT Southwestern Medical Center have uncovered the detailed shape of a key protein involved in muscle contraction.

16 Apr 2020

3D simulations will show how coronavirus spike protein binds to human cell receptors

Computational chemist Mahmoud Moradi will develop enhanced, 3D simulations of the molecular dynamics of coronavirus spike glycoproteins to gain better understanding of how the virus binds to human cells.

16 Apr 2020

How human cells recognize undesirable guests

Until now, the immune sensor TLR8 has remained in the shadows of science. A research team led by the University of Bonn has now discovered how this sensor plays an important role in defending human cells against intruders.

15 Apr 2020

Role of VRAC ion channel in fight against virus infections

VRAC/LRRC8 chloride channels play a crucial role in the transport of neurotransmitters, amino acids, and cytostatics.

14 Apr 2020

A commonly expressed protein in skin can 'turn on' allergic itch

A commonly expressed protein in skin - periostin - can directly activate itch-associated neurons in the skin, according to new research from North Carolina State University.

9 Apr 2020

Scientists discover unexpected pathway by which brown fat can burn energy

When we are exposed to sufficient cold or exercise, small clusters of brown fat cells in our bodies begin to burn up energy.

7 Apr 2020

Scientists discover molecular mechanism that regulates the body's immune sentinels

A team at the Centro Nacional de Investigaciones Cardiovasculares, working in partnership with researchers at Mount Sinai Hospital in New York, has discovered a new molecular mechanism mediated by nuclear receptors that determines the identity and expansion of macrophages--one of the cell types that act as immune sentinels in the body.

6 Apr 2020