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Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Altering the chemical properties of an anti-nausea drug enables it to enter an interior compartment of the cell and provide long-lasting pain relief, according to a new study led by researchers at NYU College of Dentistry's Pain Research Center.

23 May 2023

Brain-Wide Mapping Reveals How Serotonin Affects Animal Behavior

Because serotonin is one of the primary chemicals the brain uses to influence mood and behavior, it is also the most common target of psychiatric drugs.

16 May 2023

Researchers Elucidate the Molecular Mechanism of Protein Degradation by Extracellular Chaperones

When exposed to stressful conditions, several proteins tend to misfold and form aggregates inside or outside cells.

12 May 2023

First Gene-Edited Calf Produced With Resistance to Bovine Viral Diarrhea Virus

Scientists have collaborated to produce the first gene-edited calf with resistance to bovine viral diarrhea virus (BVDV), a virus that costs the U.S. cattle sector billions of dollars annually.

10 May 2023

T Cells can Fuel Their Ability to Attack Tumors

When you need a bit of motivation, it often has to come from within. New research suggests cancer-fighting immune cells have found a way to do just that.

9 May 2023

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

Proteins that work like air traffic controllers, controlling the flow of signals in and out of human cells, have been examined in unparalleled detail for the first time using modern microscope techniques.

5 May 2023

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

Prostate cancer frequently metastasizes to the bone and is incurable. Moffitt Cancer Center researchers are working to identify new treatment options for this subset of patients.

4 May 2023

New Bio-Inspired Molecules can Enhance Bone Regeneration in Mice

People's ability to regenerate bones declines with age and is further decreased by diseases such as osteoporosis.

2 May 2023

New Approach Could Power the Development of Advanced Cell Therapies

A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods.

2 May 2023

How Bacteria Take Action to Break Out of Dormancy

Solving a riddle that has confounded biologists since bacterial spores -; inert, sleeping bacteria -; were first described more than 150 years ago, researchers at Harvard Medical School have discovered a new kind of cellular sensor that allows spores to detect the presence of nutrients in their environment and quickly spring back to life.

2 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

A team of researchers from the University of California, Irvine, have revealed the first crystal structures of the receptor-binding domain of botulinum neurotoxin E (BoNT/E) in complex with its human neuronal receptors, synaptic vesicle glycoprotein 2A (SV2A).

28 Apr 2023

Receptor News and Research

Identifying Drugs to Put the Brakes On Accelerated Aging From HIV Infection, Treatment

Altered Anti-Nausea Drug can Penetrate Cells and Provide Sustained Pain Relief

Brain-Wide Mapping Reveals How Serotonin Affects Animal Behavior

Researchers Elucidate the Molecular Mechanism of Protein Degradation by Extracellular Chaperones

First Gene-Edited Calf Produced With Resistance to Bovine Viral Diarrhea Virus

T Cells can Fuel Their Ability to Attack Tumors

Analyzing the Complex Sequence of Events Involved in Beta-Arrestin Interactions

New CAR T Strategy Offers a Dual-Targeting Mechanism to Fight Bone Metastatic Prostate Cancer

New Bio-Inspired Molecules can Enhance Bone Regeneration in Mice

New Approach Could Power the Development of Advanced Cell Therapies

How Bacteria Take Action to Break Out of Dormancy

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Novel 3D Structure can Serve as Blueprint to Engineer New BoNT/E Variants

High-Throughput Assay to Analyze the Effects of CAR-T Cells Using Image Cytometry

Some Promising Human Antibodies can Fight New Variants of SARS-CoV-2

Neuronal Activity Necessary and Sufficient to Drive Astrocyte Development

New, Improved Dual Version of Living Yeast Biosensor to Detect All Peptide Variants

Abnormal Immune Activity in Astrocytes Causes Dementia-Related Cognitive Deficits

UH Researcher Designs New Model Expressing the Most Common Disease Mutation in USH2A

A Protein Domain Could Lead to New Treatments for COVID-19

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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