Signaling Pathway News and Research

RSS

Study sheds light on genetic causes of Alzheimer’s disease and other dementias

If we want to enhance our knowledge and treatment of Alzheimer’s disease, we need to identify genetic risk factors.

7 Apr 2022

Study helps to make sense of cell-to-cell variation in response to external stimuli

Why do genetically similar cells react to the same extrinsic stimuli, such as antibiotics, in such diverse ways?

1 Apr 2022

Non-steroidal anti-inflammatory drugs help to enhance crop genome editing tools, study says

According to plant scientists at RIKEN, a class of non-steroidal anti-inflammatory drugs might be useful for studying the molecular processes underlying plant immunity.

21 Mar 2022

New database provides extensive information on kinase-associated neural protein phosphorylation

Biological functions rely on accurate cellular communication involving different molecules. Most major signaling pathways involved in such communication, called signal transduction, often involve a family of kinases—enzymes catalyzing the transfer of phosphates between specific substrate molecules.

17 Mar 2022

Researchers develop an antibody as a tool for opening the blood-brain barrier

The brain is composed of billions of neurons-; vulnerable cells that require a protective environment to function properly.

17 Mar 2022

New PRMC-MS method enables comprehensive analysis of membrane lipids

The development of new scientific ways to see more deeply into the building blocks of nature on a cellular level has led to the some of the greatest advances in medicine over the last century.

11 Mar 2022

Intestinal cell changes are driven by the BMP signaling pathway, study finds

Intestinal cells can change specializations during their lives. The BMP signaling pathway – an important communication mechanism between cells – appears to be the driver of these changes.

2 Mar 2022

Central signaling pathway likely to help reduce the progression of autoimmune disorders

When the immune system fails and assaults the body’s own components, autoimmune disorders develop.

25 Feb 2022

MIT researchers create a new cerebrovasculature atlas

While neurons and glial cells are by far the most numerous cells in the brain, many other types of cells play important roles. Among those are cerebrovascular cells, which form the blood vessels that deliver oxygen and other nutrients to the brain.

16 Feb 2022

Study offers insight into how activated protein C may protect aging patients from reperfusion injury

A University of South Florida Health (USF Health) preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

1 Feb 2022

Targeting MAPK4 in triple-negative breast cancer may lead to improved treatments

Scientific evidence supporting the involvement of the enzyme MAPK4 in cancer growth and resistance to certain therapies has been growing quickly.

12 Jan 2022

Olfactory receptor gene may drive breast cancer metastasis to the brain

An olfactory receptor gene that aids in the sense of smell may also play a role in the metastasis of breast cancer to the brain, bones and lung, researchers from Massachusetts General Hospital have found.

4 Jan 2022

Researchers uncover a new signaling pathway essential for T cell viability

They are at the forefront in the fight against viruses, bacteria, and malignant cells: the T cells of our immune system. But the older we get, the fewer of them our body produces.

23 Dec 2021

Cancer drug effective against Alzheimer’s disease, says research

According to recent research carried out by researchers from the Weill Cornell Medicine, a gene mutation associated with Alzheimer’s disease changes a signaling pathway in specific immune cells of individuals with the disease.

7 Dec 2021

Study analyzes connections between COVID-19 severity and gene expression

Recent research reveals how genetic variations associated with severe cases of COVID-19 impact the immune cells.

25 Nov 2021

Stem cell therapy for heart disease enhanced with protein from fetal heart

The human heart, upon aging, slowly loses its capability to repair itself after injury. Damage caused by injuries like heart attack and cardiac ischemia—linked to decreased oxygen levels in the heart—can result in below normal capacity of heart functioning, making it tough for the patients to carry out daily activities.

25 Oct 2021

Novel mechanism sheds light on embryonic stem cell pluripotency

A group of scientists from Sweden recently pinpointed a cellular mechanism that is vital for the ability of these cells to remain as stem cells.

7 Oct 2021

Researchers identify the mechanism leading to deafness in Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

6 Oct 2021

Radiation therapy can reprogram heart muscle cells to a younger state, suggests study

New research from Washington University School of Medicine in St. Louis suggests that radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure.

27 Sep 2021

Study analyzes the role of heart cell protein as a potential therapeutic for heart failure

Recent research identified that a protein involved in regulating calcium signaling within heart cells can play a vital role in the prevention of chronic heart failure.

From The University of Utah 29 Jul 2021