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Proteins surrounding organs and tissues switch off natural killer cells’ “killer” function, study finds

Natural killer (NK) cells, which are part of the body’s innate, or first-line, immune response, interact with tumor cells, viral infections, and solid organ transplants, according to a new study.

21 Mar 2022

ISU researchers receive major funding to go forward on blood stem cells research

For years, scientists have been unable to create a patient’s blood cells to cure blood illnesses, but a recently implemented federal funding might help IOWA State University researchers take important steps toward making that prospect a reality.

21 Mar 2022

Experts explore how DNA packaging affects gene regulation

Russian researchers have elucidated the mechanisms involved in the activation of genes in drosophila fly sex cells.

24 Feb 2022

Infusion of intestinal organoids to replace damaged intestinal tissue

Ulcerative colitis is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the colon and rectum.

11 Feb 2022

Scientists on the verge of understanding how climate adaptation happens in plants

A century after scientists first noted that the environment contributes to the evolution of adaptive differences among plant populations, scientists are on the verge of figuring out how that adaptation happens -; by combining results from huge "common garden" experiments with genomic sequencing.

From Penn State University 9 Feb 2022

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Cancerous tumors are made up of rapidly growing, abnormally shaped, cells that can infiltrate and destroy healthy tissues, travel to other parts of the body, and form additional tumors.

8 Feb 2022

Scientists discover families of proteins that could predict organ transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

28 Jan 2022

Experts develop Immuno-CRISPR assay to detect kidney transplant complications

Doctors monitor kidney transplant recipients for signs of rejection in several ways, including biopsy.

7 Jan 2022

Biochemical signals sent from cell to cell play a key role in deciding their fate

Scientists have found a way to prove that biochemical signals sent from cell to cell play an important role in determining how those cells develop.

24 Dec 2021

Discovery may lead to a better understanding of prion and other neurodegenerative diseases

Prion diseases, such as Creutzfeldt-Jakob Disease (CJD), are fast-moving, fatal dementia syndromes associated with the formation of aggregates of the prion protein, PrP.

23 Dec 2021

300 million grant enables the establishment of new international stem cell research center

A grant from the Novo Nordisk Foundation of up to 300 million euro now enables the establishment of a major international research center focused on stem cell medicine.

20 Dec 2021

High-risk lymphoma patients may receive durable benefit from axi-cel CAR T cell therapy

Three clinical studies led by researchers at The University of Texas MD Anderson Cancer Center demonstrated enhanced responses for patients with high-risk lymphoma treated with axicabtagene ciloleucel (axi-cel) chimeric antigen receptor (CAR) T cell therapy.

13 Dec 2021

Research describes dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Clinician scientists and scientists from the National Cancer Centre Singapore and A*STAR's Genome Institute of Singapore, in collaboration with Singapore General Hospital, the National University Health System, Duke-NUS Medical School, Nanyang Technological University, and collaborators from China, Malaysia, Thailand and the Philippines, have described a dynamic genomic landscape of tumour heterogeneity in hepatocellular carcinoma (HCC).

13 Dec 2021

Immune cells in the brain mediate the link between gut microbiome and amyloid beta deposits

New research from the University of Chicago points to microglia, key immune cells in the brain, as a key mediator in the relationship between the gut microbiome and b-amyloid deposits in male mice in a model of Alzheimer's disease.

3 Dec 2021

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.

2 Dec 2021

Novel technique precisely corrects DNA errors in cultured patient cells

Scientists recently created a technique to accurately and quickly correct genetic alterations in the cultivated patient cells.

2 Dec 2021

Researchers successfully generated Leydig cells from human iPS cells

Scientists recently succeeded in creating Leydig cells from human induced pluripotent stem (iPS) cells.

2 Dec 2021

Cellular enlargement drives a decline in function of stem cells, study suggests

MIT biologists have answered an important biological question: Why do cells control their size? Cells of the same type are strikingly uniform in size, while cell size differs between different cell types. This raises the question of whether cell size is important for cellular physiology.

15 Nov 2021

Torquetenovirus in people infected by SARS-CoV-2 can be used as a marker of disease severity

Torquetenovirus (TTV) is one of the viruses most frequently found in the human organism. It is also common in monkeys and domestic animals.

8 Nov 2021

Immune system–related differences in dialysis, kidney transplant patients are amplified by SARS-CoV-2

People with kidney failure who are on dialysis or who have received a kidney transplant face a higher risk of dying from COVID-19.

8 Nov 2021

Transplant News and Research

Proteins surrounding organs and tissues switch off natural killer cells’ “killer” function, study finds

ISU researchers receive major funding to go forward on blood stem cells research

Experts explore how DNA packaging affects gene regulation

Infusion of intestinal organoids to replace damaged intestinal tissue

Scientists on the verge of understanding how climate adaptation happens in plants

Kras oncogenes use genetic reprogramming to drive tumorigenesis

Scientists discover families of proteins that could predict organ transplant rejection

Experts develop Immuno-CRISPR assay to detect kidney transplant complications

Biochemical signals sent from cell to cell play a key role in deciding their fate

Discovery may lead to a better understanding of prion and other neurodegenerative diseases

300 million grant enables the establishment of new international stem cell research center

High-risk lymphoma patients may receive durable benefit from axi-cel CAR T cell therapy

Research describes dynamic genomic landscape of tumor heterogeneity in hepatocellular carcinoma

Immune cells in the brain mediate the link between gut microbiome and amyloid beta deposits

Next-generation sequencing for minimal residual disease proven more sensitive than flow cytometry

Novel technique precisely corrects DNA errors in cultured patient cells

Researchers successfully generated Leydig cells from human iPS cells

Cellular enlargement drives a decline in function of stem cells, study suggests

Torquetenovirus in people infected by SARS-CoV-2 can be used as a marker of disease severity

Immune system–related differences in dialysis, kidney transplant patients are amplified by SARS-CoV-2

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