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Antibodies from natural controllers appear to play crucial role in eliminating hepatitis B virus

Infections in humans caused by the hepatitis B virus (HBV) represent a major public health problem. Despite the availability of effective protective vaccines, more than 250 million individuals worldwide are chronically infected according to WHO estimates.

From Institut Pasteur 14 Aug 2020

Researchers use 3D printing to produce cardiomyocytes from stem cells

The life of each human being starts from a single cell, which subsequently divides to ultimately form into an embryo.

12 Aug 2020

Discovery Could Lead To More Potent Garlic, Boosting Flavor And Bad Breath

For centuries, people around the world have used garlic as a spice, natural remedy, and pest deterrent, but they did not know how powerful garlic was.

6 Aug 2020

Machine learning can increase effectiveness of drug repurposing for psychiatric disorders

Artificial intelligence can increase the effectiveness of drug repositioning or repurposing research, according to a study published in Translational Psychiatry.

4 Aug 2020

Konstanz biologists win Ursula M. Händel Animal Welfare Prize

Marcel Leist, Professor of In-Vitro Toxicology and Biomedicine at the University of Konstanz, and Thomas Hartung, Professor of Environmental Health Sciences at the University of Konstanz and Doerenkamp-Zbinden Chair of Evidence-Based Toxicology at Johns Hopkins Bloomberg School of Public Health in Baltimore, have been awarded the Ursula M. Händel Animal Welfare Prize 2020 of the German Research Foundation.

3 Aug 2020

New tool predicts and identifies novel genes involved in various biological processes

Chromatin plays a significant role in the silencing and activation of gene transcription, and establish the fate of the cells during development.

30 Jul 2020

Heparin blocks SARS-CoV-2 infection in cell studies

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.

27 Jul 2020

Researchers use mathematical modeling to unravel the mechanisms behind tetraploidy

Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.

27 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

Researchers recreate pancreatic tissue 'in vitro' using 3D cell culture technique

Pancreatic cancer is a life-threatening disease with very poor survival rates in patients, and--despite various efforts--its treatment remains challenging.

23 Jul 2020

Researchers identify a potential biomarker of aging

The skin is the only organ that shows age more profoundly. While researchers have hypothesized about the ravages of time on skin and also the epidermal stem cells that undergo differentiation to restore the external layer of the skin, no suitable method is available to assess their aging at the molecular level.

22 Jul 2020

SARS-CoV-2 protein effectively shuts down host protein production, shows study

A detailed study of a SARS-Cov-2 protein, Nsp1, with a central role in weakening the host anti-viral immune response shows that it effectively shuts down production ofproteins in the host.

20 Jul 2020

Retinoic acid is the key to produce healthy offspring from testicular tissue transplantation

One in fifty births in Japan are said to be through in vitro fertilization, and many couples remain unable to conceive for reasons unknown. Infertility is also an undesired side-effect of lifesaving cancer treatment in childhood.

17 Jul 2020

Modified mRNAs improve efficiency of protein synthesis

Since mRNAs play a key role in protein synthesis in vivo, the use of mRNAs as medicines and for in vitro protein synthesis has been desired.

17 Jul 2020

Blood vessels communicate with peripheral neurons to regulate neuronal differentiation

Researchers at Pompeu Fabra University have shown for the first time that blood vessels communicate with neurons in the peripheral nervous system, regulating their proliferation and differentiation.

17 Jul 2020

Innovative robot can help develop medicated chewing gum

Medicated chewing gum has been recognised as a new advanced drug delivery method but currently there is no gold standard for testing drug release from chewing gum in vitro.

15 Jul 2020

New radiopharmaceutical offers precise diagnosis and treatment of prostate cancer in preclinical studies

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

14 Jul 2020

Metagenomic data on intestinal microflora can open up treatments for intestinal dysbiosis

Scientists from Osaka City University, The Institute for Medical Science, and The University of Tokyo have presented intestinal viral and bacterial metagenome data from the fecal samples collected from 101 healthy Japanese persons.

13 Jul 2020

Novel technology significantly improves the quality of stem cells

For years, stem cells have continued to have excellent potential in regenerative medicine.

6 Jul 2020

Long-term culture of human pancreatic slices as a model to study regeneration of beta cells

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.

2 Jul 2020

in vitro News and Research

Antibodies from natural controllers appear to play crucial role in eliminating hepatitis B virus

Researchers use 3D printing to produce cardiomyocytes from stem cells

Discovery Could Lead To More Potent Garlic, Boosting Flavor And Bad Breath

Machine learning can increase effectiveness of drug repurposing for psychiatric disorders

Konstanz biologists win Ursula M. Händel Animal Welfare Prize

New tool predicts and identifies novel genes involved in various biological processes

Heparin blocks SARS-CoV-2 infection in cell studies

Researchers use mathematical modeling to unravel the mechanisms behind tetraploidy

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

Researchers recreate pancreatic tissue 'in vitro' using 3D cell culture technique

Researchers identify a potential biomarker of aging

SARS-CoV-2 protein effectively shuts down host protein production, shows study

Retinoic acid is the key to produce healthy offspring from testicular tissue transplantation

Modified mRNAs improve efficiency of protein synthesis

Blood vessels communicate with peripheral neurons to regulate neuronal differentiation

Innovative robot can help develop medicated chewing gum

New radiopharmaceutical offers precise diagnosis and treatment of prostate cancer in preclinical studies

Metagenomic data on intestinal microflora can open up treatments for intestinal dysbiosis

Novel technology significantly improves the quality of stem cells

Long-term culture of human pancreatic slices as a model to study regeneration of beta cells

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