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First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Chemists identify effective inhibitors to block the uptake of SARS-CoV-2

The cell membrane is impermeable to viruses: to get inside and infect a cell, they use a range of strategies to exploit the cellular and biochemical properties of the membranes.

23 Nov 2020

Gaining new insights into bacterial pneumonia

Jacqueline Kimmey speaks to AZoLifeSciences about her research into bacterial pneumonia and the genes that drive its spread from the lungs into the blood.

23 Nov 2020

Pairs of antibodies may be more effective at preventing and treating COVID-19

Pairs of antibodies may be more effective than single antibodies at preventing and treating COVID-19, according to a new study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University in New York.

20 Nov 2020

Study outlines transient prospective stages in development of neural crest cells

Last year, researchers at the University of California, Riverside, identified the early origins of neural crest cells -- embryonic cells in vertebrates that travel throughout the body and generate many cell types -- in chick embryos.

19 Nov 2020

Several hepatitis C drugs can inhibit the SARS-CoV-2 main protease

Scientists have determined that drugs meant for treating hepatitis C can block SARS-CoV-2 main protease, which allows reproduction in the novel coronavirus.

17 Nov 2020

Scientists identify potential targets against coronavirus

Scientists comprehensively studied the RNA genomic structure of the SARS-CoV-2 coronavirus.

11 Nov 2020

Study shows how UCH37 enzyme regulates a cell’s waste management system

Researchers reported the discovery of a new enzyme, called UCH37, that controls the waste management system of a cell.

9 Nov 2020

Researchers reveal identity of the last unknown protein of autophagy

Drs. Nobuo Noda (Director) and Kazuaki Matoba (Senior Researcher) et al. at the Institute of Microbial Chemistry (BIKAKEN, Tokyo, Japan) discovered that Atg9, one of the proteins that function to mediate autophagy, has phospholipid-translocation activity (the lipid scramblase activity) between the two layers of the lipid bilayer and elucidated that the protein's activity brings about autophagosome membrane expansion.

5 Nov 2020

Researchers develop RNA catalyst that sheds light on evolution

Enzymes enable biochemical reactions that would otherwise not take place on their own. In nature, it is mostly proteins that function as enzymes.

29 Oct 2020

Scientists develop human airway stem cells to accelerate research on COVID-19, influenza

For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients.

27 Oct 2020

Dietary supplement can support immune system to combat SARS-CoV-2 infections

SPIN (SPermidin and eugenol INtegrator for the contrasting incidence of coronavirus in EU population) is a European project powered by EIT Food that is currently developing a dietary supplement supporting the function of the immune system in the fight against SARS-CoV-2 infections in the population at high risk.

22 Oct 2020

Study discusses the role of insects as a potential new food allergen

Those with food allergies must avoid allergens in food. Health problems can be triggered by even the smallest traces for those affected. This is why manufacturers of ready-made foods must list the ingredients on the packaging.

21 Oct 2020

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

19 Oct 2020

Researchers develop a new method for siRNA stabilization

In the gene controlling mechanism, known as RNA interference, the expression of particular genes is downregulated by siRNAs or endogenic microRNAs.

19 Oct 2020

Researchers assess heat-stress tolerance of different varieties of sweet potato

Climate change poses a threat to the world's subsistence crops. Heatwaves, which are likely to intensify according to climate evolution predictions, are generating levels of heat stress that are damaging to agricultural production.

15 Oct 2020

Oncopig fulfills the unmet clinical modeling needs for hepatocellular carcinoma

Volume 11, Issue 28 of Oncotarget features "Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation" by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs.

12 Oct 2020