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Researchers develop novel cell reprogramming strategy to slow down glioblastomas

Gliomas are the most common primary brain tumors in adults. Among them, high-grade glioblastomas (GBMs) are particularly known to be notoriously aggressive and invasive, which makes it challenging to treat them.

16 Sep 2021

Constitutive BAK/MCL1 complexes could predict sensitivity of chemotherapy drugs, research shows

A research team led by Prof. DAI Haiming from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences recently announced the constitutive BAK/MCL1 complexes could predict chemotherapy drugs sensitivity of ovarian cancer. The result has been published on Cell death & disease.

16 Sep 2021

Researchers reconstruct structures in the ovarian environment using mouse stem cells

Researchers led by Kyushu University have succeeded in using mouse stem cells to reconstruct structures in the ovarian environment critical for the generation of mature egg cells.

15 Sep 2021

Newly identified antibacterial mechanism could inspire novel strategies to combat bacterial pathogens

Similar to how a spider traps its prey, the cells of the human immune system cooperate to trap and “eat” bacteria.

14 Sep 2021

New approach to identify molecular targets for improved prostate cancer therapy

In a new study, researchers have introduced DSER, a technique for identifying molecular targets for enhanced therapy in prostate cancer.

14 Sep 2021

Study explores the efficiency of CasMINI, an engineered CRISPR-Cas system

A compact CRISPR-Cas system, known as CasMINI, can be employed for gene-therapy and cell-engineering applications as it is easier to deliver into cells.

7 Sep 2021

Researchers generate first "atlas" of human melanocytes in the body

Researchers at Huntsman Cancer Institute at the University of Utah (U of U) have generated the first "atlas" of human melanocytes located throughout the body.

3 Sep 2021

New approach to enhance cell-free biosynthesis with engineered yeast extracts

Think of cells as tiny factories: within their walls they have both the machinery to make products such as proteins, and the mechanisms for maintenance to keep processes running smoothly.

31 Aug 2021

Small synthetic molecules could one day cure or prevent COVID-19, herpes

In addition to antibodies and white blood cells, the immune system deploys peptides to fight viruses and other pathogens.

24 Aug 2021

Study finds the link between circular RNA and alternative splicing in gastric cancer

At the Chinese Academy of Sciences, scientists have now come up with a mechanism used by circular RNA to inhibit the metastasis of gastric cancer cells.

23 Aug 2021

Rare variants in the MX1 gene increase susceptibility to zoonotic H7N9 avian influenza

According to recent research, rare, single-nucleotide variants in the MX1 gene increase the human susceptibility to zoonotic H7N9 avian influenza infection.

23 Aug 2021

Researchers print new low-cost, reproducible cell co-cultivation system

Scientists of the MIPT Cell Signaling Regulation Laboratory have developed a new low cost reproducible system for the co-cultivation of cells. This system is based on a polymerized BSA membrane.

9 Aug 2021

Research identifies vitamin C as a key ingredient for immune cell function

A new study has now identified that it is not possible to generate stable regulatory T cells without Vitamin C or enzymes called TET proteins as much as how one cannot make a banana split without bananas.

23 Jul 2021

New method for generating metabolic profiles of individual cells

Researchers from the EMBL and the German Cancer Research Center (DKFZ) demonstrated a new technique to create metabolic profiles of individual cells.

8 Jul 2021

Researchers uncover cellular mechanisms by which the silencing therapies act in cells

Gene silencing therapies are used to interfere with, or "silence", the expression of genes that are associated with disorders. Now, a team at TMDU has uncovered some of the cellular mechanisms by which the silencing therapies act in cells.

7 Jul 2021

Kinetochore modeling could help create artificial chromosomes

Mitosis, the mechanism of cell division, is an age-old process. Yet, the process has not been fully understood or replicated.

5 Jul 2021

Researchers identify key cells involved in childhood brain cancer

A new study coordinated by the University of Trento could have identified the cell of origin of medulloblastoma—a malignant tumor in children that affects the central nervous system. In this study, scientists have used organoids to replicate the tumor tissue, for the first time.

25 Jun 2021

New airway model boosts COVID-19 research

A research team has successfully built a model of lung cells that can be used to simulate how COVID-19 infects the airways.

22 Jun 2021

Genetically engineering NK cells can target and kill glioblastoma stem cells

Preclinical research from The University of Texas MD Anderson Cancer Center finds that although glioblastoma stem cells (GSCs) can be targeted by natural killer (NK) cells, they are able to evade immune attack by releasing the TFG-β signaling protein, which blocks NK cell activity.

18 Jun 2021

Study reveals the key role of motor proteins in mitotic spindle elongation

Proper chromosome segregation into two future daughter cells requires the mitotic spindle to elongate in anaphase. However, although some candidate proteins are implicated in this process, the molecular mechanism that drives spindle elongation in human cells has been unknown, until now!

16 Jun 2021