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Study Highlights MSC-EVs Potential for Alleviating Lung Fibrosis

Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by fibroblast proliferation and extracellular matrix formation, causing structural damage and lung failure.

27 Jun 2024

Neuroscientists Discover Brain Mechanisms Behind Escape Behavior

Neuroscientists have discovered how the brain bidirectionally controls sensitivity to threats to initiate and complete escape behavior in mice.

27 Jun 2024

Researchers Develop New Way to Simulate Personalized, Microbiome-Mediated Diet Responses

Short-chain fatty acids (SCFAs) are beneficial molecules created by the bacteria residing in our gut that are closely tied to improved host metabolism, lower systemic inflammation, better cardiovascular health, lower cancer risk, and more.

25 Jun 2024

Ultrasound-Triggered Nanodroplets for Targeted Drug Delivery

Conventional drug delivery is often like cracking a nut with a sledgehammer. Whether the drug is swallowed, injected, inhaled, or absorbed through the skin, it ultimately diffuses to most parts of the body, including those where it isn’t needed – or where it even might cause harm.

22 Jun 2024

Understanding Collective Cell Behavior in Constrained Environments

Looking under the microscope, a group of cells slowly moves forward in a line, like a train on the tracks.

20 Jun 2024

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

A synthetic platform that uses dimerization modules consisting of chemical proteins to precisely control the polymerization of actin and demonstrate symmetry breaking.

19 Jun 2024

Stem cell-based kidney chip revolutionizes disease modeling and research

An organ-on-chip system containing a kidney glomerulus using human-induced pluripotent stem cells and an ultrathin membrane.

17 Jun 2024

Human Antibodies Offer Hope for Improved Black Widow Antivenom

Sera produced from horses can be used to treat serious illnesses caused by black widow bites. But this approach is not totally secure. To address this, scientists have produced entirely human antibodies that are capable of neutralizing the European black widow's alpha-latrotoxin.

13 Jun 2024

New Insights into Human Embryonic Development Using Stem Cell Models

A new study using stem cell-based models has shed new light on how the human embryo begins to develop, which could one day benefit the development of fertility treatment.

3 Jun 2024

"Cervix-on-a-Chip" Offers Promise for New Bacterial Vaginosis Treatments

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

3 Jun 2024

Immune Checkpoint Inhibitors Confer a Protective Effect on Bone by Promoting Osteogenesis

Immune checkpoint inhibitors (ICIs), widely employed anticancer agents, have been found to impact bone turnover, potentially conferring a protective effect on bone through the promotion of osteogenesis.

3 Jun 2024

Non-Destructive Test Identifies Potent Cartilage Repair Cells

Researchers from Critical Analytics for Manufacturing Personalized-medicine (CAMP) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, and collaborators from the National University of Singapore Tissue Engineering Programme (NUSTEP) have discovered a more efficient method for evaluating the ability of mesenchymal stromal cells (MSCs) to regenerate cartilage.

3 Jun 2024

Efficient Gene Editing with Compact Cas12a Protein

Researchers have created an innovative version of a critical CRISPR gene-editing protein that has effective editing activity and is small enough to be bundled into a non-pathogenic virus capable of delivering it to targeted cells.

31 May 2024

Cryo-EM Study Reveals Cas7-11-CRISPR Complex Regulation Mechanisms

In a recent study published in Signal Transduction and Targeted Therapy, Chinese researchers studied the cryo-electron microscopy structures of the CRISPR-Cas7-11 nuclease, both alone and in complex with the regulatory protein tetratricopeptide repeat fused with Cas/(human enhancer of filamentation 1) HEF1-associated signal transducer (TPR-CHAT).

24 May 2024

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Diseases that affect the brain and spinal cord can be particularly devastating, and finding new and more effective ways to treat these conditions is an important goal for researchers and clinicians alike.

23 May 2024

Unveiling the Anti-Inflammatory and Anti-Obesity Potential of Menthol-Derived Esters

Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues

20 May 2024

Takara Bio Launches PrimeCap T7 RNA Polymerase for mRNA Therapy Development

Takara Bio announces the launch of PrimeCap™ T7 RNA Polymerase (low dsRNA), a mutant T7 RNA polymerase suitable for mRNA therapeutic research and development.

20 May 2024

Hydrogel Therapy: A Novel Defense Against Viral Infections

Vaccines remain the gold standard of protection against dangerous pathogens, but take considerable time and vast resources to develop.

24 Apr 2024

Nasal Cells in Children Shield Against Severe COVID-19

Children usually have milder COVID-19 symptoms; this could be due to differences in how elderly and young people's nasal cells react to the SARS-CoV-2 virus.

16 Apr 2024

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

In the elderly, a multitude of factors contribute to diminished bone regeneration capabilities, including a reduction in the self-renewal and differentiation abilities of mesenchymal stem cells, an excessive accumulation of inflammatory signals, compromised blood vessel regeneration capacity, an imbalance between bone anabolism and catabolism, and inadequate bone innervation.

13 Apr 2024

in vitro News and Research

Study Highlights MSC-EVs Potential for Alleviating Lung Fibrosis

Neuroscientists Discover Brain Mechanisms Behind Escape Behavior

Researchers Develop New Way to Simulate Personalized, Microbiome-Mediated Diet Responses

Ultrasound-Triggered Nanodroplets for Targeted Drug Delivery

Understanding Collective Cell Behavior in Constrained Environments

Researchers Recreate Chemically Regulated Actin Polymerization to Study Membrane Dynamics

Stem cell-based kidney chip revolutionizes disease modeling and research

Human Antibodies Offer Hope for Improved Black Widow Antivenom

New Insights into Human Embryonic Development Using Stem Cell Models

"Cervix-on-a-Chip" Offers Promise for New Bacterial Vaginosis Treatments

Immune Checkpoint Inhibitors Confer a Protective Effect on Bone by Promoting Osteogenesis

Non-Destructive Test Identifies Potent Cartilage Repair Cells

Efficient Gene Editing with Compact Cas12a Protein

Cryo-EM Study Reveals Cas7-11-CRISPR Complex Regulation Mechanisms

New Chemical Modification Enhances Antisense Oligonucleotide Targeting in CNS Diseases

Unveiling the Anti-Inflammatory and Anti-Obesity Potential of Menthol-Derived Esters

Takara Bio Launches PrimeCap T7 RNA Polymerase for mRNA Therapy Development

Hydrogel Therapy: A Novel Defense Against Viral Infections

Nasal Cells in Children Shield Against Severe COVID-19

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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