The BioXplorer range from H.E.L Group comprises automated bioreactor systems designed for fermentation, cell culture and bioprocess development. Available in different reactor volumes and configurations, the systems support parallel experimentation, process optimisation and scale-up.
The BioXplorer 100 and 400 are benchtop parallel bioreactor systems, with XL configurations providing additional reactors for increased experimental throughput. The BioXplorer 5000 offers larger working volumes for process development and scale-up.
All systems provide automated monitoring and control of key bioprocess parameters, enabling reproducible experiments under a range of operating conditions.
Features and Options
BioXplorer Configuration Comparison
 |
 |
 |
| BioXplorer 100 |
BioXplorer 400 |
BioXplorer 5000 |
Image Credit: H.E.L Group
| Specification Point |
BioXplorer 100/100XL |
BioXplorer 400/400XL |
BioXplorer 5000/5000XL |
| Number of independent parallel bioreactors |
8 (100); 16 (100XL) |
4 (400); 8 (400XL) |
1 |
| Bioreactor material |
Glass body, stainless steel lid |
Glass body, stainless steel lid |
Glass, interchangeable insulated vessels |
| Total volume |
200 mL |
500 mL |
Interchangeable 1-5 L vessels |
| Working volume |
50-150 ml |
120-400 mL |
1-5 L |
| Sterilization |
Autoclavable bioreactors (including sensors) |
| Autoclavable bioreactors (including sensors) |
|
- |
| Temperature Range |
0 – 135 °C |
0 – 135 °C |
−50 to 250°C (circulator-dependent) |
| Temperature resolution |
0.1 °C |
0.1 °C |
Stability typically ±0.1°C |
| Stirrer drive |
Magnetically driven captive impeller |
Magnetically driven captive impeller or overhead agitation (magnetically coupled) |
Overhead agitation |
| Stirrer speed |
250 – 1500 rpm |
Magnetic: 250–1,500 rpm; overhead: 20–2,000 rpm |
Up to 2,000 rpm / 400 Ncm |
| Liquid additions with independent control for each bioreactor |
2 as standard, options for upto 2 additional liquid feeds |
Automated liquid feeds, including volumetric syringe pumps; number not specified |
| Gas additions |
1 set of 8 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set |
Automated gas feeds; number of MFCs not specified |
| Standard options for MFC calibration |
Air, oxygen as option |
- |
| Gas spargers |
1 |
- |
| Exhaust gas |
Peltier cooled condenser |
- |
| pH control |
1-way control (2-way control optional) |
Available |
| pH sensing |
0-14 |
Available |
| Polarographic DO sensing |
Standard |
DO sensing available |
| DO control |
Gas/liquid flow rate, stirrer speed |
Available |
| BioVIS – Understand cell density trends without taking samples |
Optional |
Available |
| Tandem off-gas analysis |
Optional |
Available |
| Foam/Level detection |
Optional |
- |
| Control PC and software |
Windows® PC with WinISO control software (preinstalled) |
WinISO: recipe planning, data logging and ELN export |
- Specification dependent on configuration or not confirmed. Contact H.E.L Group for further details.
BioXplorer 5000 temperature range depends on the selected circulator. Lower-temperature operation on BioXplorer 100 and 400 configurations may require an optional circulator.
The following features and options are available across the BioXplorer range, unless otherwise specified.
Intelligent Software Control and Analysis
- H.E.L's WinISO software provides automated experiment control, real-time data logging and monitoring.
- Independent control of reactor parameters and user-configurable experimental procedures.
- Automated feedback control of stirring, liquid and gas additions based on sensor measurements, time-based profiles or event detection.
- Real-time graphical display and export of experimental data, including CSV files.
Safety Features
- User-configurable operating limits and alarm conditions.
- Automated monitoring and shutdown procedures.
- Hardware and software safety features for controlled bioprocess operation.