With eight 500 ml bioreactors, the BioXplorer 400XL enables rapid optimization of crucial parameters for aerobic fermentations. Its parallel bioprocessing capabilities, along with the customizable configuration of the bioreactor lid, offer the flexibility to select which parameters to monitor in real time. When paired with WinISO, the BioXplorer 400XL can adapt to changes in the bioprocess, facilitating full automation of the fermentation process.

BioXplorer 400XL from H.E.L Group. Image Credit: H.E.L Group

Overview

Enhanced Bioreactor System

The BioXplorer 400XL contains eight bioreactors, each designed for aerobic fermentation and with a working capacity ranging from 120 mL to 400 mL. These bioreactors can be outfitted with a wide range of probes and sensors, and the system supports a number of gas and liquid feed combinations. The capacity to accurately regulate and monitor up to eight bioprocesses at the same time substantially speeds up screening and optimization studies, resulting in more thorough process knowledge and faster scale-up.

Flexibility and Control

BioXplorer 400XL combines increased larger volumes with the replication and parallelization capabilities of having eight independent reactors controlled by WinISO.

This software simultaneously monitors the bioreactor's key parameters while allowing precise control over them, ensuring ideal conditions are consistently maintained. When combined with customizable options and a wide range of liquid and gas pumps, as well as agitation capabilities, it provides powerful tools for characterizing and optimizing bioprocesses.

Features and Options

Source: H.E.L Group

Specification Point BioXplorer 400XL
Number of independent parallel bioreactors 8
Bioreactor material Glass body, stainless steel lid
Total volume 500 ml
Working volume 120 – 400 ml
Sterilization Autoclavable bioreactors (including sensors)
Temperature Range 0 – 135 °C
Temperature resolution 0.1 °C
Stirrer drive Magnetically driven captive impeller or Overhead agitation (magnetically coupled)
Stirrer speed
  • Magnetically Driven – 250 – 1500 rpm
  • Overhead Agitation – 20- 2000 rpm
Auto re-couple
  • Magnetically Driven – Yes
  • Overhead Agitation – N/A
Liquid additions with independent control for each bioreactor Magnetically Driven – 2 as standard, options for up to 2 additional liquid feeds
Gas additions 1 set of 8 mass flow controllers allowing independent control for each reactor as standard, option for 1 additional set
Standard options for MFC calibration Air, oxygen as option
Gas spargers 1
Exhaust gas Peltier cooled condenser
pH control 1-way control (2-way control optional)
Polarographic DO sensing Standard
DO control Gas/liquid flow rate, stirrer speed (Optional)
BioVIS – Understand cell density trends without taking samples Optional
Foam/Level detection Optional
Control PC and software Windows® PC with WinISO control software preinstalled:
  • Fully independent control of all reactors
  • Advanced control strategies for stirring and liquid and gas additions based on feedback from sensors, time-based profiles, or event detection
  • Real-time display and logging of all reaction parameters
  • Easy export of data in a range of formats, including .csv

* Upper temperature limit for data acquisition from standard pH and DO probes is 60 ˚C and 40 ˚C, respectively. The lower temperature limit requires an integrated circulator option. 

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