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Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

Funding will enable the development of Spirea’s pipeline of antibody drug conjugate therapeutics for the treatment of solid tumours.

From Spirea 14 Jun 2022

Computational approach could enable large-scale analyses of tumor-specific total mRNA levels from patient samples

Researchers at The University of Texas MD Anderson Cancer Center have developed a new approach to quantify tumor-specific total mRNA levels from patient tumor samples, which contain both cancer and non-cancer cells.

14 Jun 2022

ZDHHC18-mediated MDH2 palmitoylation upholds mitochondrial respiration and boosts ovarian cancer malignancy

To drive anabolic processes, epithelial ovarian cancer (EOC) is heavily reliant on the tricarboxylic acid (TCA) cycle and oxidative phosphorylation.

13 Jun 2022

Researchers discover a new interferon-gamma receptor signaling pathway

The interferon-gamma receptor (IFNgR) signaling pathway has been identified to be crucial for the vulnerability of glioblastoma tumors to death by CAR T-cell immunotherapy, according to researchers at Massachusetts General Hospital (MGH).

10 Jun 2022

Dietary modifications can lower symptoms of allergic reactions, a new study reveals

Micronutrient deficits can increase inflammation and make the immune system more susceptible to allergens. Iron deficiency indicates danger to immune cells and causes an excessive immunological response.

8 Jun 2022

Novel insights into how some bacteria evade antibiotics

Scientists have revealed how antibiotics can regress certain fast-growing bacteria. The research was published in the journal eLife on June 8th, 2022.

8 Jun 2022

Axol Bioscience introduces CiPA-validated human stem cell-derived ventricular cardiomyocytes to help improve drug discovery

Axol Bioscience Ltd. (Axol), an established provider of iPSC-derived cells, media, and characterization services for life science discovery, today announced that its human induced pluripotent stem cell (iPSC)-derived ventricular cardiomyocytes have undergone comprehensive in vitro pro-arrhythmia assay (CiPA) validation.

From Axol Bioscience Ltd 8 Jun 2022

Study discovers new antibiotics effective against drug-resistant tuberculosis

Every year, 1.5 million people die from infections caused by Mycobacterium tuberculosis. Antibiotics are available to treat tuberculosis, but the bacteria has evolved multi-drug resistant (MDR), extensively drug-resistant (XDR), and fully drug-resistant (TDR) strains in recent years.

1 Jun 2022

Study reveals how RNAi workhorse protein optimizes to keep protein synthesis on track

Proteins are made in cells in the same way as they are made in factories. However, making too much at the wrong moment may lead to illnesses like cancer, so they use RNA interference (RNAi) to regulate production.

1 Jun 2022

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Highly structured chromatin encodes the program of life with only one set of genes in the core of every cell. Since various genes are stimulated at different periods of life while staying silent elsewhere, this is feasible. Some genes from a former life stage are hidden deep within the nuclear perimeter, while others manage to break out.

1 Jun 2022

Researchers analyze the involvement of immune cells in lung cancer survival

Lung cancer affects approximately 48,500 persons in the United Kingdom every year. New treatments are urgently needed because only around 20% of patients live 5 years after diagnosis, and it is the leading cause of cancer death.

1 Jun 2022

Researchers created ultrasound-guided microbubbles to enhance immunotherapy performance

The University of Texas MD Anderson Cancer Center scientists have created an ultrasound-guided cancer immunotherapy approach that promotes systemic antitumor immunity and increases immune checkpoint blockade therapeutic potential. Nature Nanotechnology published the results of the pioneering study.

1 Jun 2022

Scientists discover a new left-handed Z-DNA technique to kill hard-to-treat tumors

An international collaboration of scientists has discovered a new technique to kill cancers that are difficult to treat, according to an article published in Nature.

30 May 2022

Researchers determine the novel medical target of angiogenesis for ccRCC patients

Research reported that the DMDRMR/miR-378a-5p/ DAB2IP axis enhances angiogenesis and sunitinib resistance, suggesting that it could be used for patients with ccRCC.

30 May 2022

Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.

From National University of Singapore (NUS) 27 May 2022

Genetic testing advances help to uncover primary immune deficiency diseases

Infections caused by primary immunodeficiency diseases (PID) can be persistent and life-threatening. More than 450 PIDs have been identified, yet diagnosing them quickly and accurately remains a difficulty.

27 May 2022

Easy-to-find soft corals make the elusive "anti-cancer" compound, scientists report

The bottom of the ocean is full of mysteries but scientists have recently uncovered one of its best-kept secrets. For 25 years, drug hunters have been searching for the source of a natural chemical that had shown promise in initial studies for treating cancer.

From The University of Utah 24 May 2022

Clinical News and Research

Spirea raises £2.4M ($3M) to develop antibody drug conjugates in cancer

Computational approach could enable large-scale analyses of tumor-specific total mRNA levels from patient samples

ZDHHC18-mediated MDH2 palmitoylation upholds mitochondrial respiration and boosts ovarian cancer malignancy

Researchers discover a new interferon-gamma receptor signaling pathway

Dietary modifications can lower symptoms of allergic reactions, a new study reveals

Novel insights into how some bacteria evade antibiotics

Axol Bioscience introduces CiPA-validated human stem cell-derived ventricular cardiomyocytes to help improve drug discovery

Study discovers new antibiotics effective against drug-resistant tuberculosis

Study reveals how RNAi workhorse protein optimizes to keep protein synthesis on track

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Researchers analyze the involvement of immune cells in lung cancer survival

Researchers created ultrasound-guided microbubbles to enhance immunotherapy performance

Scientists discover a new left-handed Z-DNA technique to kill hard-to-treat tumors

Researchers determine the novel medical target of angiogenesis for ccRCC patients

Drugs used for myelodysplastic syndrome could potentially activate a sleeping oncogene

Genetic testing advances help to uncover primary immune deficiency diseases

Easy-to-find soft corals make the elusive "anti-cancer" compound, scientists report

Researchers devise a new treatment approach to cure aggressive brain tumors

Immune-boosting drugs with antibiotics may reduce the health risks of fungal infections

Research shows how visible hotspots may be easy to target with immune-stimulating drugs

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