Immunotherapy News and Research

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Immunotherapy is the concept of using the immune system to treat disease, for example, developing a vaccine against cancer. Immunotherapy may also refer to the therapy of diseases caused by the immune system, allergies for example.

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Lung cancer patients who may not react well to immunotherapy (ICB) could be identified by the oncogenic activation of MYC, an important gene in the development of cancer.

17 Apr 2023

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

17 Apr 2023

A Nanoplasmonics Approach to Observe Real-Time Production of Cell Secretions

Researchers at the University of Geneva have developed a novel optical imaging approach that provides a four-dimensional view of cell secretions in real-time, including their spatial and temporal dynamics.

13 Apr 2023

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain cancer that often kills within a year of diagnosis. Surgery is almost impossible because of the tumors' location.

13 Apr 2023

A New, Cost-Effective Therapy to Treat a Wide Range of Cancers

A potential immunotherapy method for treating metastatic melanoma is adoptive cell therapy (ACT). The method, which utilizes the use of immune cells extracted from the patient’s own tumors, could offer cancer patients new options for treatment by eschewing radiation therapies and harsh chemotherapy drugs.

11 Apr 2023

Immunotherapy Response in Advanced Melanoma: Effect of Previous Treatments

According to a study conducted by UCLA, patients with advanced melanoma responded differently to PD-1 checkpoint blockade immunotherapy depending on a variety of variables, including whether or not they had previously received CTLA-4 blockade, another type of immunotherapy.

11 Apr 2023

Gut Microbiome and Enhanced Tumor Immune Response in Pancreatic Cancer Survivors

Even as pancreatic cancer treatments advance, only around 9% of patients live beyond five years. Scientists have failed to identify genetic distinctions that explain why some patients live for a long time and others do not, so they have moved their emphasis to the gut microbiome.

5 Apr 2023

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

New research from Washington University School of Medicine in St. Louis suggests that transposable elements in various cancers potentially may be used to harness novel immunotherapies against tumors that don't typically respond to immune-based treatments. Shown is a 3D rendering of cancer cells.

4 Apr 2023

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

Cancer immunotherapies that recruit a patient's own immune system to destroy tumors have transformed the treatment of many types of cancer. Yet these therapies do not elicit universally good treatment responses.

31 Mar 2023

Novel inhibitor, hopeaphenol, blocks HIV expression

In the United States, around 1.2 million people are living with HIV as of 2022. Many of these people can now live productive, symptom-free lives thanks to antiretroviral therapies, but a solution that permanently removes HIV from an infected person’s body is still a long way off.

30 Mar 2023

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

Cancer that has spread to areas like the lungs can apply the brakes to a natural pathway that should recruit killer T cells directly to where it has metastasized, scientists report.

29 Mar 2023

Thickness of cancer cells' glycocalyx barrier determines immune cell evasion of tumors

One of the ways that cancer cells hide from the body's immune system is by forming a thin surface barrier called the glycocalyx.

27 Mar 2023

Keeping lymph nodes in the body can boost the efficacy of cancer immunotherapy

Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells.

21 Mar 2023

Macrophages likely to be a potential target for ER+ breast cancer

Most immunotherapies that aim to increase T cell activity are ineffective in treating estrogen receptor-positive (ER+) breast cancer. A new study of invasive ER+ breast cancers led by researchers at the University of Pittsburgh School of Medicine implies that targeting a different type of immune cell called macrophages may be a more effective approach.

From University of Pittsburgh 20 Mar 2023

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

Most immunotherapies, which aim to boost T cell activity, work poorly in treating estrogen receptor-positive (ER+) breast cancer.

20 Mar 2023

Decreased viral infection severity in females linked to extra copy of epigenetic regulator

It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery – until possibly now.

20 Mar 2023

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

In a Phase II trial led by researchers from The University of Texas MD Anderson Cancer Center, adding ipilimumab to a neoadjuvant, or pre-surgical, combination of nivolumab plus platinum-based chemotherapy, resulted in a major pathologic response (MPR) in half of all treated patients with early-stage, resectable non-small cell lung cancer (NSCLC).

20 Mar 2023

Potential approach to improve solid tumor T cell therapy

Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a new strategy that uses a “one-two punch” to assist T cells in attacking solid tumors.

17 Mar 2023

Highlighting a potential sex‐specific precision immunotherapy strategy

Immunotherapy is an effective form of treatment for various types of cancer. However, its effect on pancreatic cancer is restricted and varies between men and women. Karolinska Institutet scientists have observed a possible explanation for this gender difference.

17 Mar 2023

High correlation between the product of a gene in the majority of cancers

The product of a gene expressed in most cancers, including the most prevalent type of head and neck cancer, has been linked to elevated levels of white blood cells that produce antibodies inside tumors, according to researchers at the University of California San Diego School of Medicine and UC San Diego Moores Cancer Center.

14 Mar 2023

Immunotherapy News and Research

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Study Presents Crucial Themes in the Biology of Pancreatic Cancer

A Nanoplasmonics Approach to Observe Real-Time Production of Cell Secretions

Potential Therapy for Lethal Pediatric Brain Cancer Using ASO Technology

A New, Cost-Effective Therapy to Treat a Wide Range of Cancers

Immunotherapy Response in Advanced Melanoma: Effect of Previous Treatments

Gut Microbiome and Enhanced Tumor Immune Response in Pancreatic Cancer Survivors

Jumping Genes in Various Cancers may be Used to Direct Novel Immunotherapies to Tumors

Neutrophils can affect the success of immunotherapy in treating cancer, study shows

Novel inhibitor, hopeaphenol, blocks HIV expression

Additional therapeutic maneuver may be needed to stop some metastasized tumors Cancer That...

Thickness of cancer cells' glycocalyx barrier determines immune cell evasion of tumors

Keeping lymph nodes in the body can boost the efficacy of cancer immunotherapy

Macrophages likely to be a potential target for ER+ breast cancer

Immune landscape in invasive ER+ breast cancers reveals a macrophage-driven microenvironment

Decreased viral infection severity in females linked to extra copy of epigenetic regulator

Neoadjuvant dual immunotherapy and chemotherapy improve outcomes in patients with resectable NSCLC

Potential approach to improve solid tumor T cell therapy

Highlighting a potential sex‐specific precision immunotherapy strategy

High correlation between the product of a gene in the majority of cancers

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