Malignant News and Research

RSS

HKU researchers develop new drug discovery strategy targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

29 Dec 2020

Study uncovers how shattered chromosomes make cancer cells more aggressive

Cancer is one of the world's greatest health afflictions because, unlike some diseases, it is a moving target, constantly evolving to evade and resist treatment.

From UC San Diego 24 Dec 2020

New analysis technique could pave way for major breakthroughs in immunotherapy

In a new study, researchers at Uppsala University have been able to show differences in how Rituximab, a monoclonal antibody drug, interacts with the blood of healthy individuals compared to patients with chronic lymphatic leukaemia.

14 Dec 2020

Researchers discover protein crucial for growing life-saving blood stem cells

A group of scientists from the Centre for Genomic Regulation (CRG) in Barcelona and Columbia University in New York City has discovered a protein that is crucial for expanding the usually scarce, life-saving blood stem cells.

11 Dec 2020

Study reveals new target to make breast cancer more sensitive to immunotherapy

Although immunotherapy has been effective in treating different kinds of cancer, it is still unsuccessful when it comes to treating breast cancers.

11 Dec 2020

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Using 3D mapping techniques to unravel mystery of blood stem cells

Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells.

26 Nov 2020

Study may lead to new strategies that minimize inflammatory reactions after cell transplants

The term leukaemia is used to describe a group of malignant diseases of the haematopoietic system, in which precursors of the white blood cells (leucocytes) proliferate uncontrollably.

20 Nov 2020

Study suggests that melatonin may be a viable treatment option for COVID-19

New findings indicate that melatonin could be a potential treatment option for COVID-19.

10 Nov 2020

Scientists discover link between two signaling pathways crucial to growth of colon cancer

In breakthrough colon cancer research, scientists at ChristianaCare's Helen F. Graham Cancer Center & Research Institute have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The study is published today in the journal PLOS ONE.

29 Oct 2020

Researchers discover new ways to block the colonization and spread of tumor cells

What role do the lymphatic vessels play in the metastasis of cancer cells? Scientists from the German Cancer Research Center and the Mannheim Medical Faculty of the University of Heidelberg developed a method to investigate this question in mice.

27 Oct 2020

VAV1 gene mutations may promote growth of T-cell tumors in laboratory mice

Life is an exquisite orchestration of growth and change, with checks and balances that fine-tune complex entwined interactions, both intrinsic and external.

13 Oct 2020

Developing a 'Trojan Horse' nanotherapy to fight breast cancer

With a nearly $2.6 million grant from the National Institutes of Health, Michigan State University researchers are using nanoscopic particles to turn the body's own cells into weapons that cancer won't see coming.

12 Oct 2020

Study shows thymoquinone compound selectively kills prostate cancer cells

According to a new study reported in the Oncogene journal, the thymoquinone (TQ) compound selectively destroys prostate cancer cells at advanced phases.

9 Oct 2020

Type and direction of force on a cell can alter gene expression

Tissues and cells in the human body are subjected to a constant push and pull - strained by other cells, blood pressure and fluid flow, to name a few.

5 Oct 2020

Memory training for the immune system

After an infection of the human body with a pathogen, a cascade of reactions will usually be set into motion.

29 Sep 2020

Enhancing the effectiveness of immunotherapy against melanoma

Researchers at the University of Bern have discovered a mechanism in the body’s own immune system which is responsible for the maturation and activation of immune cells.

21 Sep 2020

Study sheds new light on the structure and function of ‘immortality protein’

The nuclear magnetic resonance spectrometer of Kazan Federal University played a crucial role in analyzing the telomerase of Hansenula polymorpha.

14 Sep 2020

New technology reveals experimental drugs that help suppress the growth and spread of tumor

A new technology that allows researchers to peer inside malignant tumors shows that two experimental drugs can normalize aberrant blood vessels, oxygenation, and other aspects of the tumor microenvironment in non-small cell lung cancer (NSCLC), helping to suppress the tumor's growth and spread, UT Southwestern researchers report.

4 Sep 2020

Researchers discover the developmental process of strong immune T-cells

There are memory cells that remember previously encountered pathogens and help to react quickly and strongly when exposed to them again.