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Lab-Grown Human “Blood Factory” Advances Drug and Disease Testing

The “blood factory” of the human body is composed of specialized tissue that includes bone cells, blood vessels, nerves, and various other cell types.

19 Nov 2025

Sabotaging T Cell Exhaustion for Cancer Therapy

Like all hardworking things, the cytotoxic T lymphocytes (CTLs) of the immune system charged with detecting and destroying cancer cells tend to get very tired-so much so, in fact, that they can even die from exhaustion.

18 Nov 2025

Neurons and Other Nondividing Cells Respond Differently to CRISPR-Cas9 Gene Editing

The gene editing tool known as CRISPR-Cas9 is changing what's possible for treating a wide range of diseases caused by genetic mutations.

18 Nov 2025

New "Ultra-Mild" Method Corrects Cancer DNA Methylation Test Errors

Traditional bisulfite sequencing damages DNA, while enzyme-based alternatives are inconsistent. A novel methylation analysis method, called UMBS-seq, was published this week in Nature Communications. UMBS-seq achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection.

13 Nov 2025

Animal Testing to Be Phased Out Faster as UK Unveils Roadmap for Alternative Methods

Animal testing in science is set to be phased out faster under a new plan to deliver on the government’s manifesto commitment, unveiled by Science Minister Lord Vallance today (Tuesday 11 November).

13 Nov 2025

AlphaSync Brings Continuous Updates to Global Protein Structure Predictions

The shape, or structure, of proteins determines how they work, making it essential for researchers to have access to high-quality structural models.

12 Nov 2025

Rare Stress-Sensitive Neurons Hold the Key to Healthy Brain Blood Flow

While the exact causes of neurodegenerative brain diseases like Alzheimer's and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow.

12 Nov 2025

St. Jude Scientists Discover Hidden Binding Pocket in Nuclear Receptors

A study from St. Jude Children's Research Hospital uncovered an alternative binding pocket within nuclear receptors, revealing a much-needed new therapy route for this important class of drug targets.

7 Nov 2025

Comprehensive Kinase Atlas Redefines Regulation of Gene Transcription Machinery

The enzyme RNA polymerase II transcribes genes into messenger RNA. This process is guided by modifications to the enzyme's "tail" called phosphorylation patterns.

7 Nov 2025

Transforming Stomach Cells into Insulin Factories for Diabetes Treatment

Type 1 diabetes is caused by an insufficient production of the hormone insulin by cells in the pancreas called beta cells and estimated to affect 9.5 million people worldwide.

7 Nov 2025

Using AI and "Protein Language" Models to Speed Monoclonal Antibody Design

Artificial intelligence (AI) and "protein language" models can speed the design of monoclonal antibodies that prevent or reduce the severity of potentially life-threatening viral infections, according to a multi-institutional study led by researchers at Vanderbilt University Medical Center.

6 Nov 2025

Oxidative Stress May Hold Clues to the Origins of Repetitive Behaviors

Abnormal repetitive behaviors in mice are strongly linked to multiple biomarkers of oxidative stress, which occurs when antioxidants cannot counteract the effects of harmful molecules in the body, according to a study published November 5, 2025, in the open-access journal PLOS One by Kendall Coden and Dr. Joseph Garner of Stanford University, U.S.

6 Nov 2025

3D Ultrasound That Sees Entire Organ Blood Flow in Real Time

This study presents a multi-lens ultrasound system that offers tenfold higher resolution for whole-organ imaging, improving microvascular network visualization.

6 Nov 2025

RNA Molecules Alter Genome Structure to Silence Critical Neuronal Genes During Stress

What if the brain's response to stress could be read not in fleeting neurotransmitter bursts, but in the quieting of genes deep inside chromatin? Researchers at the University of Alabama at Birmingham have now shown that stress hormones may silence crucial neuronal genes through an unexpected class of RNA molecules that operate not by encoding proteins, but by reshaping the genome's architecture.

5 Nov 2025