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New Study Reveals How Genetic Mutations Hijack the Parkinson's LRRK2 Switch

Researchers at Weill Cornell Medicine have uncovered how a key Parkinson's protein called LRRK2 shifts between inactive and active forms, revealing the structural changes that enable certain mutations to push the protein into an overactive state.

11 Aug 2026

McMaster Team Identifies Natural Immune Defense Against Advanced Fatty Liver Disease

Researchers at McMaster University have discovered that a naturally occurring hormone best known for suppressing appetite and promoting weight loss also helps protect the liver from inflammation through a previously unknown signaling pathway, opening new possibilities for treating advanced fatty liver disease.

11 Aug 2026

New Living Material Restricts Cyanobacterial Cell Division to Boost Ethylene Output

Finnish researchers have taken an important step toward long-lasting production of renewable chemicals and fuels using photosynthetic microorganisms.

11 Aug 2026

Researchers Engineer AI Framework to Solve Longstanding Protein Isoform Mystery

A single human gene can produce multiple protein isoforms through alternative splicing, greatly expanding the functional diversity of the proteome.

11 Aug 2026

New Single-Cell Database Reveals Hidden Inner Workings of Spinal Cord Circuits

Scientists at St. Jude Children's Research Hospital created a single-cell atlas of a key class of spinal neurons involved in motor coordination. From that resource, they identified a small subgroup of interneurons associated with the speed of rhythmic movements such as walking. The findings, which have implications for understanding spinal cord function and recovery from injury, were published today in Nature Communications.

11 Aug 2026

Bone Marrow T Cells Exhibit Conditional Preparedness Against Cancer

A team led by researchers from the German Cancer Research Center (DKFZ), the HI-STEM Stem Cell Institute, and Medical Clinic V at Heidelberg University Hospital (UKHD) has characterized T cells in the bone marrow in cases of multiple myeloma and acute myeloid leukemia: A specific group of tumor-reactive T cells can recognize and, in principle, fight cancer cells, but is often not sufficiently activated.

10 Aug 2026

3D Genome Mapping in Rare Immune Cells Reveals New Crohn’s Disease Genes

A new study co-led by Prof. Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology, has been published in Nature Genetics.

10 Aug 2026

Rare Immune Cell Spatial DNA Maps Uncover Hidden Autoimmune Triggers

A new study co-led by Prof. Valeriya Malysheva, group leader at the VIB-UAntwerp Center for Molecular Neurology, has been published in Nature Genetics.

8 Aug 2026

Decoding Brown Rat Pangenomes Provides Accurate Blueprints for Human Illness

Researchers have created the most complete genetic profile of the brown rat to date, according to a UTHealth Houston-led team, paving the way for scientists to more accurately research the genetic links to conditions like heart disease, kidney disease, high blood pressure, and stroke.

8 Aug 2026

Mapping Alternative RNA Splice Isoforms to Identify Novel Therapeutic Targets

Proteogenomics represents a transformative approach in cancer research that bridges the gap between genomic alterations and their functional consequences at the protein level.

8 Aug 2026

Research Reevaluates Crucial Microtubule Stabilizing Protein in Dementia Progression

A protein named tau, which has been highly implicated in the world's No. 1 cause of dementia - Alzheimer's disease - and several other neurodegenerative disorders, may spur these diseases in a way that differs greatly from the pathological pathway usually ascribed to it.

7 Aug 2026

Fruit Fly Genetics Explain How Early Embryos Dictate Head Development

One of the most important milestones in the early life of an organism is when the embryo breaks symmetry and arranges itself to form the head (anterior) at one end and tail (posterior) at the other end.

7 Aug 2026

Scientists Track Specialized Small RNAs Governing Safe Stem Cell Development

Scientists are shedding new light on a little-known biological system that could help unlock the full potential of stem cell therapy, one of the most promising areas of modern medicine.

7 Aug 2026

Emerging m6A RNA Biology Explains Brain Vulnerability to Environmental Hazards

A growing understanding of RNA biology is reshaping how scientists view the relationship between environmental toxicants, brain development, and neurodegenerative disease.

7 Aug 2026

Living Organisms Depend on Bacterial Production of Critical Vitamin B12

All living organisms need a little bit of it to form red blood cells and DNA, as well as to build and support brain and nerve cells. But it's hard to come by: Humans don't make it. Animals don't make it. Plants don't make it.

7 Aug 2026

Modulating T Cell Exhaustion Offers Novel Therapeutic Pathways in Transplantation

A comprehensive new review examines the complex role of T cell exhaustion in organ transplantation, highlighting how this dysfunctional immune state can both promote graft tolerance and create vulnerabilities to infection and malignancy.

7 Aug 2026

Localized Biochemical Halos Shield Pancreatic Beta Cells From Rejection

A protein known as interleukin 10 (IL-10) is the lynchpin of a new method to protect transplanted cells from host immune system aggression.

6 Aug 2026

Uncovering Novel Biomechanical Bacterial Defenses to Optimize Future Antibiotics

A group of Cornell College students and their professor have discovered surprising results in their research on antimicrobial peptides, which are being studied as a method of combating antibiotic resistance.

6 Aug 2026

Tireless Stem Cells Drive Continuous Renewal Across High Friction Human Intestines

Digestion is hard on the cells that line the human gut, and they are constantly being shed and replaced. This renewal is driven by a population of tireless stem cells. These stem cells can both replace the various types of intestinal cells that have been lost as well as renew themselves.

6 Aug 2026

Stable RNA Structures Revolutionize Quality of Life in Oncology Care

A new review highlights the growing importance of circular RNAs (circRNAs) in addressing one of the most pressing challenges in modern oncology: treatment-related toxicity.

6 Aug 2026