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Study Reveals Shared Genetic Roots Between ALS and Hereditary Spastic Paraplegia

Motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP), share physical similarities but have been largely viewed as genetically distinct.

3 Nov 2025

Intracellular Compounds Offer Blueprint for Next-Generation Targeted Therapies

New research led by the University of Minnesota Medical School demonstrates that molecules acting as "molecular bumpers" and "molecular glues" can rewire G protein-coupled receptor (GPCR) signaling, turning the cell's busiest receptors into precision tools - opening the door to a new generation of safer, smarter medicines.

3 Nov 2025

Scientists Build the First Cellular Atlas of the World’s Deadliest Mosquito

The most dangerous animal in the world just got easier to study-and perhaps defeat one day.

3 Nov 2025

Expansion Microscopy Reveals Hidden Architecture of Oceanic Plankton

Plankton are the invisible engines of life on Earth, producing much of the planet's oxygen and forming the foundation of the oceanic food chain.

3 Nov 2025

Researchers Use Bacterium’s Own Defenses to Amplify Antibiotic Power

Scientists at St. Jude Children's Research Hospital have found a way to use a bacterium's own drug resistance mechanisms against itself, presenting a potentially safer and more effective way to treat certain antibiotic-resistant infections.

3 Nov 2025

Frazzled Protein Found to Shape Fast Neural Connections in Fruit Flies

Florida Atlantic University neuroscientists have uncovered a surprising role for a protein named "Frazzled" (known as DCC in mammals) in the nervous system of fruit flies, showing how it helps neurons connect and communicate with lightning speed.

3 Nov 2025

How Leucine Boosts Cellular Energy Production

Researchers at the University of Cologne have found that a particular dietary amino acid enhances cellular energy, thereby creating new opportunities for the treatment of metabolic disorders.

3 Nov 2025

Rapid Cell-Free Crystallization Method Reveals 3D Structures of Flexible Sugars

A quick, purification-free method was developed by researchers at Institute of Science Tokyo, to capture the detailed 3D structures of flexible sugar molecules.

31 Oct 2025

New Method Doubles Therapeutic Cell Production for Duchenne Muscular Dystrophy

If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.

31 Oct 2025

Breakthrough Small Molecule Offers New Hope for Diabetes Treatment

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

31 Oct 2025

Unexpected Enzyme Strategy Behind Antibiotic Resistance

Researchers at McGill University have identified two enzymes that employ an unprecedented mechanism to provide resistance, thereby introducing a new dimension in the fight against antimicrobial resistance (AMR), which ranks among the top 10 global public health challenges.

31 Oct 2025

How Gut Bacteria Influence Mammalian Cell Physiology

The microbiome-the trillions of bacteria, viruses, and fungi that live quietly in our body-plays a crucial role in shaping human health by providing a variety of micronutrients necessary for vital functions.

30 Oct 2025

Research Sheds New Light On How Neurons Transmit Strains and Stresses

How do embryos develop? Why does the cortex of the mammalian brain fold? How do we feel touch at our fingertips? These and other fundamental biological questions remain unsolved. Yet, scientists know they all rely on a common principle: the conversion of a physical stimulus into a biochemical signal.

30 Oct 2025

Fruit Fly Study Reveals New Details on Alzheimer's Disease Risk Genes

Scientists have identified hundreds of genes that may increase the risk of developing Alzheimer's disease but the roles these genes play in the brain are poorly understood.

30 Oct 2025

Unlocking the Secrets of Neural Ion Channels

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores that let charged ions enter a cell-and the molecular gatekeepers that help control them.

30 Oct 2025

Reversible Epigenetic Switches Influence Memory Formation

Our experiences leave traces in the brain, stored in small groups of cells called "engrams". Engrams are thought to hold the information of a memory and are reactivated when we remember, which makes them very interesting to research on memory and age- or trauma-related memory loss.

30 Oct 2025

Researchers Uncover How Pseudomonas Bacteria Sense and Build Biofilms

The bacterium known as Pseudomonas aeruginosa is an unwelcome visitor in the human body. Serious infections can result when a bunch of these bugs settle together on a surface to form a biofilm - a community of microbes like the slime on spoiled food, but in this case residing inside a person.

29 Oct 2025