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Novel Two-Dimensional Mapping Combines Generation Probability with Somatic Hypermutation

A research team led by Associate Professor Yohei Funakoshi, Associate Professor Kimikazu Yakushijin, and Professor Hironobu Minami of the Division of Medical Oncology/Hematology at Kobe University Hospital, together with Associate Professor Goh Ohji of the Division of Infectious Disease Therapeutics and Takaji Matsutani of Anymics Inc., has developed the pGen-SHM plot.

5 Oct 2026

Spatial Single-Cell Transcriptomics Maps Cellular Niches in Fatal COVID-19 Lungs

Researchers at the University of Liège have used imaging-based spatial single-cell transcriptomics to map the cellular organization of lungs from people who died with severe COVID-19.

5 Oct 2026

Researchers Discover Key Protein Mechanism Enabling Fungal Drug Resistance

The battle lines have finally shifted in the war against a deadly fungal disease.

5 Oct 2026

Engineered Biological Bandages Utilize Human Epicardial Cells for Heart Repair

Researchers have discovered a new cell type that may help regulate blood vessel growth in the heart during development and in response to injury, according to a study from Weill Cornell Medicine. Working with zebrafish, they found that the new cell type helps stabilize the vascular network that supplies oxygen to growing cardiac muscle.

5 Oct 2026

Gut Bacterial Gene tnaA Converts Dietary Tryptophan Into Toxic Indole

Researchers at LMU have discovered how a metabolite produced by gut bacteria can influence brain damage after stroke.

5 Oct 2026

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Blocking USP15 in ovarian cancer cells disrupts growth and enhances chemotherapy sensitivity, revealing a potential target for overcoming treatment resistance.

1 Oct 2026

Experts Extend Lives of Animals By Activating ‘Energy Saver’ Mode

The study, published today in Aging Cell, found strong evidence that triggering a protein governing energy level may help organisms live longer, in some cases by over 25%.

1 Oct 2026

Single-Molecule Optical Tweezers Visualize Real-Time Dynamic Protein and DNA Interactions

A protein that's essential to every cell's ability to turn off unnecessary genes is well known for its key function of compacting genes and its connection to cancer when it undergoes mutation.

1 Oct 2026

Invasive E. coli Strains Promote Host Invasion of Harmless Strains

When scientists assess how dangerous a bacterium is, the first question often seems simple: can it be stopped or killed?

1 Oct 2026

Electron Microscopy Imaging Confirms Piezo1-Dependent Axonal Sheath Structural Remodeling

Researchers at Upstate Medical University have identified a key mechanism that helps determine the length of myelin, the protective coating that surrounds many nerve fibers and allows signals to travel efficiently through the nervous system.

1 Oct 2026

Single-Molecule Optical Tweezers Visualize Real-Time Dynamic Protein and DNA Interactions

A protein that's essential to every cell's ability to turn off unnecessary genes is well known for its key function of compacting genes and its connection to cancer when it undergoes mutation. But until now, scientists weren't quite sure how the protein gets where it needs to go to keep genes bound up so they aren't activated.

1 Oct 2026

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors - which have transformed treatment for some cancers - benefit only 17%–23% of patients with head and neck squamous cell carcinoma. These are cancers that arise from cells lining the mouth, throat and voicebox.

1 Oct 2026

Singlet Oxygen Oxidizes Electron-Rich Base Pairs to Cleave Bacterial DNA

Engineers have developed a new approach for turning ordinary water into a weapon against antibiotic-resistant bacteria, according to a study publishing September 30 in the Cell Press journal Chem Catalysis.

1 Oct 2026

Kupffer Cells Increase Apolipoprotein Secretion in Response to Indigestible Plastics

Microplastics appear capable of significantly impairing the function of phagocytes in the liver, at least in mice. In turn, this disrupts the metabolism of this vital organ and increases the build-up of fat inside it. These are the key findings from a joint German-Austrian study led by the University of Bonn, details of which have now been published in the journal "Nature Metabolism."

1 Oct 2026

A Flash of Blue Light Helped Cells Overcome a Major Division Defect

Cell division represents a complex process. Central to this intricacy is a cellular structure devoid of a membrane, known as the centrosome, consisting of over 200 different components.

30 Sep 2026

Innovative OpenFISH Technique Enables Integrated Spatial Molecular Imaging in Tissues

Spatial transcriptomics (ST) shows which genes are being expressed and where within a tissue. Spatial metabolomics (SM), on the other hand, maps the location of metabolites—small molecules produced or used by cells—within tissue.

30 Sep 2026

Novel Therapeutic Approaches for Malaria Using Anti-Cancer Compound Derivatives

Molecules known for their anti-cancer activity have proven effective in combating Plasmodium falciparum, the parasite that causes malaria.

30 Sep 2026

Gut-Derived Neutral Ceramidase Regulates MASH Through Microbial and Epithelial Signaling

Metabolic dysfunction-associated steatohepatitis (MASH) is often viewed through the lens of hepatic lipid accumulation, inflammation and fibrosis.

30 Sep 2026

Decoding the Mechanisms Behind Long-Term Epigenetic Gene Regulation Shifts

The transmission of biological traits from one generation to the next is generally attributed to DNA. But could some changes be passed on without altering the DNA sequence?

30 Sep 2026

Lifeblood, UQ and SMART CRC Pump New Life Into Lab-Grown Blood Production

Lifeblood researchers are among only a few research groups in the world who are already growing fully functional red blood cells from donor stem cells in the lab but producing them in quantities large enough for use in patients is inefficient and expensive.

29 Sep 2026

Cell News and Research

Novel Two-Dimensional Mapping Combines Generation Probability with Somatic Hypermutation

Spatial Single-Cell Transcriptomics Maps Cellular Niches in Fatal COVID-19 Lungs

Researchers Discover Key Protein Mechanism Enabling Fungal Drug Resistance

Engineered Biological Bandages Utilize Human Epicardial Cells for Heart Repair

Gut Bacterial Gene tnaA Converts Dietary Tryptophan Into Toxic Indole

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Experts Extend Lives of Animals By Activating ‘Energy Saver’ Mode

Single-Molecule Optical Tweezers Visualize Real-Time Dynamic Protein and DNA Interactions

Invasive E. coli Strains Promote Host Invasion of Harmless Strains

Electron Microscopy Imaging Confirms Piezo1-Dependent Axonal Sheath Structural Remodeling

Single-Molecule Optical Tweezers Visualize Real-Time Dynamic Protein and DNA Interactions

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Singlet Oxygen Oxidizes Electron-Rich Base Pairs to Cleave Bacterial DNA

Kupffer Cells Increase Apolipoprotein Secretion in Response to Indigestible Plastics

A Flash of Blue Light Helped Cells Overcome a Major Division Defect

Innovative OpenFISH Technique Enables Integrated Spatial Molecular Imaging in Tissues

Novel Therapeutic Approaches for Malaria Using Anti-Cancer Compound Derivatives

Gut-Derived Neutral Ceramidase Regulates MASH Through Microbial and Epithelial Signaling

Decoding the Mechanisms Behind Long-Term Epigenetic Gene Regulation Shifts

Lifeblood, UQ and SMART CRC Pump New Life Into Lab-Grown Blood Production

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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