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Ancient Gut Microbes Traveled Globally With Prehistoric Human Ancestors

As waves of humans left Africa tens of thousands of years ago, eventually populating the entire planet, they were joined on their world-conquering ride by the trillions of microorganisms that compose the gut microbiome.

8 Oct 2026

Targeting Host Cellular Repair Mechanisms Enhances Tissue Resistance to Infection

Epithelial cells form the body's frontline barriers, helping keep microbes, toxins, and other harmful substances out. Yet these protective cells are constantly exposed to threats, including microbial infections.

6 Oct 2026

Engineered 3D miBrains Model Human Neurovascular Units and Pathology

Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease.

26 Sep 2026

3D Stem-Cell miBrains Model Complex Neurovascular Pathology in Human Tissue

25 Sep 2026

Breakthrough Study Explains Developmental Origins of the Human Brain

For centuries, scientists have thought of the brain as a single, unified organ. But new research led by Stanford Medicine reveals that what we call the brain is two distinct organs that evolved independently over hundreds of millions of years.

21 Sep 2026

Scientists Grow Human Brain Organoids in Cortex-Depleted Mice

Stanford Medicine scientists have chalked up a major advance in growing human brain cells outside of the human brain - and outside of laboratory glassware.

17 Sep 2026

Synchronized Gene Regulatory Pathways Defend C. diff Against Host and Microbiota Threats

The pathogen Clostridioides difficile (C. diff) - a leading cause of hospital-acquired infections - must contend with a variety of threats inside the harsh environment of the gut to survive and grow.

10 Sep 2026

Multi-Omic Integration Reveals Novel Gene-Disease Links in Undiagnosed Rare Conditions

Researchers from Queen Mary University of London, the Berlin Institute of Health at Charité (BIH) and Genomics England have shown that measuring proteins in the blood can provide important additional clues about the effects of genetic variants, helping to identify diagnoses and potential new disease-causing genes that genome sequencing alone has been unable to resolve.

10 Sep 2026

Bulky Molecular CRISPR Systems Barely Fit Inside Single Viral Vectors

The ability to precisely adjust the expression of genes inside the human body - ramping up protective ones and tamping down harmful ones - holds enormous potential for treating and preventing disease.

31 Aug 2026

Mice Studies Prove Engineered Molecules Eradicate Tumors Within Eleven Days

A two-headed molecule designed by Stanford Medicine researchers hijacks one of the most common protein drivers of B-cell lymphoma, flipping it from its role as a promoter of cell growth into an arbiter of cell death.

22 Aug 2026

New Research Links Chronic Inflammation to Tumor Microenvironment Epigenetic Changes

Immune checkpoint inhibitors have revolutionized cancer treatment, yet many colorectal tumors remain resistant. Even among patients who initially respond, more than half eventually develop resistance, highlighting the need to better understand how tumors evade immune attack.

19 Aug 2026

New Study Links TIMP2 Loss to Microglial Immune Dysfunction

Researchers at The Icahn School of Medicine at Mount Sinai have identified a role for the youth-associated protein TIMP2 in supporting the healthy function of microglia, the brain's resident immune cells.

17 Aug 2026

Genomic Database Analysis Identifies New Target for Triple-Negative Breast Tumors

Triple-negative breast cancer accounts for approximately 15% of all breast cancer cases. It is characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, rendering it insensitive to conventional endocrine and targeted therapies.

13 Aug 2026

Research Reevaluates Crucial Microtubule Stabilizing Protein in Dementia Progression

A protein named tau, which has been highly implicated in the world's No. 1 cause of dementia - Alzheimer's disease - and several other neurodegenerative disorders, may spur these diseases in a way that differs greatly from the pathological pathway usually ascribed to it.

7 Aug 2026

University of Oklahoma Study Uncovers Internal Recycling System in Photoreceptors

For decades, scientists believed that photoreceptors in the retina relied primarily on neighboring support cells, known as the retinal pigment epithelium (RPE), to remove waste. While the RPE is still responsible for clearing away the worn-out tips of photoreceptors each day, new findings from the University of Oklahoma reveal that photoreceptors also perform much of their own internal housekeeping.

30 Jul 2026

Study Identifies Immune Cell Failures as Aging Drivers

We may age at different rates, but none of us escapes aging.

17 Jul 2026

Stanford Researchers Find Dual Protein Mechanism Driving Psoriasis Inflammation

Two proteins with opposing functions orchestrate the development and maintenance of healthy skin, Stanford Medicine researchers have found.

26 Jun 2026

Common Genetic Variant Increases Colorectal Cancer Risks for General Population

A team of scientists from the Barbara Ann Karmanos Cancer Institute, Wayne State University, and institutions across the U.S., have published a landmark paper on the role of TGFBR1*6A, a naturally occurring genetic mutation in the TGFBR1 gene found in approximately 14 percent of the general population.

24 Jun 2026

New Cell Therapy Modifies Natural Killer Cells Against Cancer

Scientists have made great progress in harnessing the body's own immune cells to treat so-called liquid tumors, cancers of the blood and lymphatic system.

11 Jun 2026

Study Reveals Asymptomatic Mpox Infections Drive Transmission Among Men

A Kaiser Permanente study of nearly 8,000 men shows that in mid- to late 2024, mpox was far more common among men who have sex with men than previously thought.

15 May 2026