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TRF1 Knockout Mice Exhibit Healthier Metabolic States Without Telomere Shortening

A new research paper was published in Volume 17, Issue 9 of Aging-US on September 17, 2025, titled "Depletion of the TRF1 telomere-binding protein leads to leaner mice with altered metabolic profiles."

28 Oct 2025

Mitochondria and Lysosomes Orchestrate Metabolic States of Regulatory T Cells

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

27 Oct 2025

Understanding the Ecological Trap Threatening Winter-Ready Species

Even as autumn days grow shorter, a warming climate means Ohio winters aren't as cold as they were just a few decades ago, according to National Oceanic and Atmospheric Administration data.

10 Oct 2025

Breakthrough in Understanding How Tick-Borne Encephalitis Virus Infects Human Brain Cells

The protein on human cells that tick-borne encephalitis virus (TBEV) uses for infection has now been identified-a major step toward understanding how TBEV causes neurological disease and for developing antiviral drugs.

3 Oct 2025

PNPLA3 Gene Variant Linked to Liver Injury After Chemotherapy in Colorectal Cancer Patients

A new international study led by Mayo Clinic researchers has identified a genetic factor that may explain why some patients with colorectal cancer that has spread to the liver experience more severe liver damage after chemotherapy.

30 Sep 2025

PANoptosis Could Revolutionize Liver Cancer Diagnostics and Treatment

Liver cancer, particularly hepatocellular carcinoma (HCC), remains one of the deadliest cancers, driven by high recurrence and resistance to therapy.

22 Sep 2025

Metastatic Lung Cancer Cells Cozy Up to Neurons and Form Synapses

Small cell lung cancer cells that metastasize to the brain cozy up to neurons and form working electrical connections, called synapses, according to an upcoming study led by Stanford Medicine researchers.

11 Sep 2025

Aptamer Group Introduces Novel Biomarker Discovery Service

Aptamer Group plc, the leading developer of next-generation synthetic binders delivering innovation to the life science industry, today announced the launch of its biomarker discovery service, offering researchers in pharmaceutical, biotechnology, and diagnostic development an innovative approach to identify and validate new disease markers.

28 Aug 2025

Genes and Diet Work Together to Regulate the Liver’s Circadian Clock

Our bodies follow a natural 24-hour cycle known as the circadian rhythm that influences everything from sleep to metabolism.

27 Aug 2025

RNA Binding Proteins and EVs Offer Clues to Cancer's Evasion of Immune Response

Certain types of biochemical processes can impair the immune system's ability to recognize and kill cancer cells. Purdue University's W. Andy Tao and his associates have developed a new way to study these processes.

27 Aug 2025

New Research Explains How Alcohol Inhibits Gut Health

Alcohol-associated liver disease (ALD) is a leading cause of liver transplantation and mortality globally, and its effect is only increasing.

27 Aug 2025

Epigenetic Noise Enables Cells to Shift Identity and Influence Immunity

All cells in the body contain the same DNA, but different cell types express different genes; skin cells express genes for the skin, liver cells express liver genes, and so on.

21 Aug 2025

ISS National Lab-Sponsored Experiment Tests 3D Bioprinted Tissue for Growing Artificial Livers

To explore how 3D bioprinted liver tissue constructs complete with vascular channels behave in microgravity, the Wake Forest Institute for Regenerative Medicine (WFIRM) is sending an investigation to the International Space Station (ISS).

21 Aug 2025

New Technology Maps Over 140 Proteins Across Human Tissues

Each organ in the human body contains different types of cells arranged in specific ways.

20 Aug 2025

Smaller Scale Mutations in HNF1A Gene Nudge Millions Toward Type-2 Diabetes

Mutations in a single gene, HNF1A, are known to cause MODY3, a rare, early onset form of diabetes.

7 Aug 2025

Hemostatic Dressing Developed for Severe Burn Injuries

A team led by Dr. Chao Zhong and Bolin An of the Chinese Academy of Sciences' Shenzhen Institute of Advanced Technology, along with Dr. Yan Liu of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, created a novel hemostatic dressing based on bacterial cellulose (BC) that allows for quick and long-lasting bleeding control.

4 Aug 2025