Prostate Cancer News and Research

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Prostate cancer is the most common non-skin cancer in the United States and the third most common cancer worldwide. More than 1 million men in the United States have prostate cancer and it is the second leading cause of cancer death amongst men after lung cancer. In 2009, an estimated 192,280 new cases are expected to be diagnosed and approximately 27,360 men are expected to die from the disease. Castration-resistant prostate cancer (CRPC) is defined as prostate cancer that continues to grow despite all standard-of-care hormonal (anti-androgen) therapies. Patients with castration-resistant (also known as hormone-refractory) prostate cancer have few treatment options and a poor prognosis.

New Proximity Labeling Method Discovers Critical Protein Interactions in Cancer

Using a photochemically driven labeling technique, a Cornell University-led research group has devised a strategy for capturing cancer-specific protein-to-protein interactions, which could one day spawn targeted therapies for prostate, small-cell lung, pancreatic and other deadly forms of the disease.

14 Aug 2026

Deep-Learning Holography Detects Elusive Circulating Tumor Cells in Prostate Cancer

Researchers combined microfluidic enrichment, AI-assisted holography, and fluorescence profiling to identify circulating tumor cell candidates in 13 men with metastatic castration-resistant prostate cancer and 8 healthy donors. The platform found higher median candidate counts in patients, while nearly two-thirds of PSMA-positive candidates lacked EpCAM, suggesting EpCAM-dependent assays could miss some cells.

27 Jul 2026

New Research Links CALB2 Gene to Mechanoresistance in Metastatic Prostate Cancer

When a cancer cell leaves the original tumor to spread to a new, far away location, it first has to survive what most cells cannot: periodic high force moments in the vessels and heart of up to 5,000 dynes per centimeter squared as it circulates throughout the body.

24 Jul 2026

CRISPR Gene Editing Reveals How Enhancer Hierarchies Regulate Gene Expression

Enhancers are pieces of DNA that act like switches, regulating when genes are turned on and off and how strongly they are activated.

23 Jul 2026

Researchers Discover Genetic Markers Predicting Prostate Cancer Ferroptosis

A new study from researchers at The University of Texas MD Anderson Cancer Center has identified genetic factors that determine whether prostate cancers are susceptible to a type of cell death known as ferroptosis.

3 Jul 2026

Study Identifies Potential Metabolic Biomarkers for Metastatic Castration-Resistant Tumors

Ceramides-lipid molecules in cells that affect many physiological functions including cell differentiation, migration, and death-and their metabolites have been implicated in the development of cancer and other conditions.

26 May 2026

Restricted Interaction Peptides Change Shape to Lock Therapy Inside Solid Tumors

Medications are designed to treat diseased tissues while sparing healthy ones, often by attaching the drug to something that helps guide it directly to its target.

14 May 2026

New Method Predicts Cancer Patient Outcomes at Single-Cell Resolution

Oregon Health & Science University researchers have developed a first-of-its-kind method to predict cancer patient survival using advanced molecular data from individual cells.

22 Apr 2026

New Platform Models Cancer Metastasis and Cell Cluster Survival

Metastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they travel through the bloodstream.

28 Mar 2026

New Computational Tool Streamlines Analysis of Massive Genomic Datasets

In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models or cultured cells.

19 Mar 2026

Aged Neutrophils With CCL3 Drive Tumor Growth Across Cancers

Renowned as first responders to threatening infections, neutrophils also happen to feature prominently in the microenvironment of tumors, where they and other immune cells play opposing and frequently mutable roles in promoting-or resisting-cancer progression.

6 Feb 2026

Genomic Test Can Accurately Identify Early Recurrence Risk in Prostate Cancer Patients

A new Moffitt Cancer Center study suggests a widely used genomic test can more accurately identify which men with early prostate cancer are at high risk for their disease to come back quickly after treatment, particularly African American men who face the highest burden from this disease.

26 Dec 2025

Breakthrough Research Uncovers Dual Role of Enzymes in Prostate Cancer

A major international study has uncovered a new vulnerability in prostate cancer cells that could help improve treatment for one of the most common cancers affecting men.

15 Oct 2025

Microbial Signatures Help Distinguish Colorectal Tumors from Other Cancers

Colorectal cancer is unique in having its own microbial 'fingerprint' – according to new research from the University of East Anglia.

4 Sep 2025

New Cellular Signature Reveals Why Some Prostate Cancers Resist Standard Treatment

A new study from University of Michigan Rogel Cancer Center researchers identifies a cellular signature that explains why about one-third of prostate cancers respond especially poorly to treatment.

9 Jul 2025

Fusion Genes Emerge as Key Drivers in Cancer Development

Fusion genes, arising from abnormal chromosomal rearrangements, are gaining recognition as pivotal players in cancer development. These genetic alterations result in the creation of hybrid genes with altered functions, often driving tumor progression.

25 Jun 2025