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Freeze Thaw Cycles Reveal How Lipid Membranes Shape Early Protocell Evolution

Modern cells are complex chemical entities with cytoskeletons, finely regulated internal and external molecules, and genetic material that determines nearly every aspect of their functioning.

21 Jan 2026

Hidden Sperm RNA Remodeling With Age May Impact Next Generation

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity and stillbirth. But what drives this increased risk remains unknown.

21 Jan 2026

Neuronal Activity Maps Challenge Traditional Anatomical Divisions of Prefrontal Cortex

For more than a century, maps of the brain have been based on how brain tissue looks under the microscope.

21 Jan 2026

Yeast-Based Platform Achieves Animal-Free High Quality Chondroitin Sulfate

By systematically redesigning multiple metabolic modules inside Komagataella phaffii, the researchers achieved both high product yield and high sulfation quality, two goals that have long been difficult to reach at the same time.

21 Jan 2026

Engineering Escherichia coli for Sustainable Biosynthesis of Lauryl Glucoside

By reconstructing a non-natural metabolic route in Escherichia coli, the researchers demonstrated that simple sugars can be biologically converted into lauryl glucoside through the coordinated production of its fatty alcohol precursor and a final glycosylation step.

21 Jan 2026

First Fully Synthetic Bacteriophage Engineering System for Antibiotic-Resistant Bacterium

Bacteriophages have been used therapeutically to treat infectious bacterial diseases for over a century.

21 Jan 2026

Rigid Protein Molecular Rulers Enable Precise Control of Antibody Conformation

By extending a naturally rigid bacterial protein by 50% while preserving geometry and stability, the study introduces protein-based "molecular rulers" that could probe antibody shape, limit unwanted motion, and support safer, more effective antibody drug design.

21 Jan 2026

Bacteria Use One Simple Strategy to Navigate Complex Worlds

Just like every other creature, bacteria have evolved creative ways of getting around. Sometimes this is easy, like swimming in open water, but navigating more confined spaces poses different challenges.

19 Jan 2026

Decoding the Molecular Logic of Histamine Signaling in the Brain

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses.

19 Jan 2026

A Hidden Nanomachine Behind Constant Cellular Secretion

Scientists uncover the tiny machine that delivers essential molecular packages to the cell surface, a fundamental activity for maintaining healthy cells.

19 Jan 2026

Mapping the Human E3 Ligase Landscape

Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, which must be synthesized, deployed, and removed with precision.

19 Jan 2026

Model Proteins Could Bring Order to Protein Science

Protein scientists could improve reproducibility and coordination across the field by rallying around a small, shared set of "model proteins," according to a new Perspective by Connecticut College chemist Marc Zimmer.

19 Jan 2026

Replacing Large Mouse Gene Regions with Human DNA

Humanized mouse models are essential for investigating human gene function; however, the complete replacement of mouse genes with entire human sequences has posed significant technical challenges.

19 Jan 2026

Study Overturns Understanding About How T Cells Recognize Lipid Antigens

A new discovery about how cells communicate with each other in the body's immune system has revealed deeper insights for an international team of scientists into fundamental immune system function.

16 Jan 2026

Unveiling How a Respiratory Bacterium Obtains Lipids and Targets Fatty Tissues

A multidisciplinary team has uncovered a key mechanism that allows the human bacterium Mycoplasma pneumoniae-responsible for atypical pneumonia and other respiratory infections-to obtain cholesterol and other essential lipids directly from the human body.

16 Jan 2026