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T-cells are a critical component of the adaptive immune system and are indispensable in protecting humans from pathogenic infections.

St. Jude Scientists Discover Gene-Regulatory Pathway Protecting Gut Immune Balance

Trillions of bacteria live in the human gut without triggering an immune response. Scientists at St. Jude Children's Research Hospital have now discovered a gene-regulatory pathway that helps maintain this delicate balance. Published today in Science Advances, they showed that a type of immune cell, regulatory T cells, co-opt a well-known general gene expression pathway called COMPASS to suppress inappropriate immune responses and prevent lethal inflammation and autoimmunity.

30 Oct 2026

Evaxion Announces 89% Vaccine Target Precision and Sustained T-Cell and Clinical Responses at Three-Year Follow-Up in Phase 2 Trial with Personalized Cancer Vaccine EVX-01

Evaxion A/S, a clinical-stage TechBio company developing novel immunotherapies with its pioneering AI-Immunology™ platform, announces new three-year immune and clinical outcome data for personalized cancer vaccine EVX-01 in patients with advanced melanoma.

From Evaxion A/S 24 Oct 2026

Metabolic Reprogramming Enhances Gamma Delta CAR T Solid Tumor Clearance

By turning a patient's own immune cells into stronger cancer-fighting cells, CAR T-cell therapy has transformed how some blood cancers are treated. But it's been harder to extend this approach to solid tumors, including cancer that has spread to the bone.

21 Oct 2026

Clinician-Led Approach Could Give Doctors a Control Dial for Cell Therapies

A clinician-led research team has developed a gene-editing platform that could give doctors more control over cell therapies, making them more practical for patients with complex immune conditions.

20 Oct 2026

Dendritic Cell STING Activation Licenses Cytotoxic T Lymphocyte Priming

Immune checkpoint inhibitors (ICIs) have transformed cancer care, yet only a subset of patients benefit. A major barrier is tumor microenvironment (TME) heterogeneity: "hot" tumors are enriched with cytotoxic T lymphocytes (CTLs) and respond better, while "cold" tumors lack T-cell infiltration or are shielded by immunosuppressive barriers.

20 Oct 2026

Balancing Immune Cells May Unlock Hidden Human Regenerative Potential

In a study of fingertip regeneration, a team led by JAX Senior Research Scientist James Godwin found that some immune cells in mice can attack and kill cells needed to rebuild bone, while a subset of those same immune cells can protect the bone-making cells and allow regeneration to continue.

16 Oct 2026

Novel Molecular Pathway Identified to Combat T-Cell Exhaustion in Cancer

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center used a CRISPR screen to identify a key molecular pathway that drives exhaustion in cancer-fighting immune cells, limiting their ability to keep tumors under control.

16 Oct 2026

Transcriptional Repression Mechanism Prevents Protective Immune Pathways From Triggering Autoimmunity

A preclinical study by researchers at UT Southwestern Medical Center has discovered how a protein called ZBTB44 helps prevent excessive immune activity that can cause inflammation in the colon, the main section of the large intestine. The findings, published in Nature Immunology, may help explain how immune responses go awry in a range of chronic inflammatory and autoimmune diseases

13 Oct 2026

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors - which have transformed treatment for some cancers - benefit only 17%–23% of patients with head and neck squamous cell carcinoma. These are cancers that arise from cells lining the mouth, throat and voicebox.

1 Oct 2026

Study Establishes Immune Cell Trafficking as Viable Alzheimer's Target

There is no treatment available today to stop the death of brain cells in neurodegenerative diseases known as tauopathies, including Alzheimer's disease, in which twisted clumps of a protein called tau accumulate in the brain.

29 Sep 2026

Researchers Reveal How p53 Tumor-Suppressor Protein Hide From T Cells

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see.

18 Sep 2026

UCLA Breakthrough Generates Thousands of Allogeneic T-Cell Doses From Single Cord Blood Sample

T cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision.

9 Sep 2026

Optical Metabolic Imaging Profiles Single-Cell Metabolic Fitness in Blood Without Dye Labeling

A routine blood sample contains a diverse collection of immune cells that can reveal important clues about health and disease. These cells, known as peripheral blood mononuclear cells (PBMCs), are widely used to study infections, autoimmune disorders, cancer, and the immune system's response to treatment.

3 Sep 2026

UNC Researcher Wins Mathers Foundation Grant to Study T-Cell Metabolism

Jessica Thaxton, PhD, MsCR, associate professor in the Department of Cell Biology and Physiology at the UNC School of Medicine and co-leader of the Cancer Cell Biology Research Program at UNC Lineberger Comprehensive Cancer Center, has been awarded a prestigious $700,000 grant from the Mathers Foundation to support research into the role of the endoplasmic reticulum in T-cell metabolism and cancer development.

2 Sep 2026

Novel T-Cell Engineering Strategy Prevents Deadly Osteosarcoma Lung Metastasis

Scientists at St. Jude Children's Research Hospital have discovered that removing the gene for Regnase-1 from engineered immune cells makes them more effective at treating relapsed osteosarcoma.

26 Aug 2026

Multiple Specialized Immune Cells Cooperate to Suppress Opportunistic Lung Fungi

Most people carry the fungus Cryptococcus neoformans in their lungs for life and never know it, held in check by the immune system.

21 Aug 2026

New Research Links Chronic Inflammation to Tumor Microenvironment Epigenetic Changes

Immune checkpoint inhibitors have revolutionized cancer treatment, yet many colorectal tumors remain resistant. Even among patients who initially respond, more than half eventually develop resistance, highlighting the need to better understand how tumors evade immune attack.

19 Aug 2026

New Lipid Vesicles Evade Immune Cells to Target Cancer Tumors

Red blood cells serve as the foundation for nanocarriers that show promise in a new study as effective and efficient vehicles for gene therapy, tumor targeting and other medical treatments.

18 Aug 2026

Bone Marrow T Cells Exhibit Conditional Preparedness Against Cancer

A team led by researchers from the German Cancer Research Center (DKFZ), the HI-STEM Stem Cell Institute, and Medical Clinic V at Heidelberg University Hospital (UKHD) has characterized T cells in the bone marrow in cases of multiple myeloma and acute myeloid leukemia: A specific group of tumor-reactive T cells can recognize and, in principle, fight cancer cells, but is often not sufficiently activated.

10 Aug 2026

Newly Identified Protein Prevents T Cells From Destroying Cancer Cells

Researchers at Mayo Clinic have identified a protein that cancer cells use to suppress the body's immune response, a finding that could support the development of new treatments to improve the effectiveness of cancer immunotherapies.

5 Aug 2026