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Single-Cell RNA Sequencing Maps Neuroblastoma Intratumoral Heterogeneity

Neuroblastoma is the most common solid tumor found outside of the brain in children, yet why some children respond well to treatment while others do not has remained poorly understood. St. Jude Children's Research Hospital scientists and their collaborators built one of the most comprehensive datasets of neuroblastoma cells to date, using it to define the tumor's cell types and identify a gene signature marking a malignant cell population tied to poor prognosis.

10 Oct 2026

Retrotransposon Reactivation Suggests Reverse Transcriptase Inhibitors Lower Cancer Risk

A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown.

9 Oct 2026

Prime Editing Generates Genomic Ticker Tapes Tracing Millions of Developing Cells

Growing inside each of us is a cellular family tree.

9 Oct 2026

Enzyme Knockdown Repolarizes Immune Cells for Targeted Immunotherapy

Our bodies contain immune cells called macrophages.

8 Oct 2026

Mitochondrial Genome Dynamics Influence Intrinsic Tumor Aggressiveness

Mitochondria are small organelles within cells that play a central role in vital cellular processes, especially energy production.

8 Oct 2026

Higher-Order Receptor Clustering Acts as Hidden Lymphangiogenic Signal Amplifier

Lymphatic vessels act as the body's "drainage system," collecting excess fluid from tissues. When lymphatic drainage is impaired because lymphatic vessels are underdeveloped, damaged, or dysfunctional, lymphedema can develop, causing swelling, particularly in the arms and legs.

6 Oct 2026

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Blocking USP15 in ovarian cancer cells disrupts growth and enhances chemotherapy sensitivity, revealing a potential target for overcoming treatment resistance.

1 Oct 2026

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Immune cells can reach head and neck tumors, but once there, many stop functioning. This helps explain why immunotherapy with immune checkpoint inhibitors - which have transformed treatment for some cancers - benefit only 17%–23% of patients with head and neck squamous cell carcinoma. These are cancers that arise from cells lining the mouth, throat and voicebox.

1 Oct 2026

Targeted Y Chromosome Deletions Disrupt Key Cellular Immune Response Pathways

A new study found that cancer cells selectively chip away gene-rich sections of the Y chromosome, triggering ripples that regulate tumor growth.

29 Sep 2026

Oncogene-Induced Senescence Exhibits Dual Role in Tumor Suppression and Progression

Researchers at NYU Abu Dhabi have discovered that a single cancer-causing gene can trigger different responses in cells, with some helping to prevent tumors while others may contribute to their development.

29 Sep 2026

Post-Translational Modification Crosstalk Regulates Oncogenic Protein Stability and Activity

A review published in Genes & Diseases highlights the complex interplay between protein arginine methylation and ubiquitination, two forms of protein modification that can profoundly influence cancer development, progression and treatment response. The article brings together current understanding of how these interconnected molecular processes regulate proteins involved in cancer and identifies opportunities for future therapeutic approaches.

28 Sep 2026

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

A new study from The Wistar Institute has found a link between the nervous system and the rapid development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

26 Sep 2026

Chronic Inflammation Linked to Heart Changes and Risks

Chronic inflammation, indicated by GlycA levels, has been linked to heart changes and increased cardiovascular risk, highlighting genetic and environmental interactions.

25 Sep 2026

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Study Uncovers Two-Protein Repair Mechanism Preserving Circular ecDNA Stability

Researchers at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues have discovered that a type of rogue DNA found in aggressive cancers has a hidden structural weakness - and that blocking a single repair protein can cause it to fall apart, suggesting a new therapeutic opportunity.

24 Sep 2026

Tumor News and Research

Single-Cell RNA Sequencing Maps Neuroblastoma Intratumoral Heterogeneity

Retrotransposon Reactivation Suggests Reverse Transcriptase Inhibitors Lower Cancer Risk

Prime Editing Generates Genomic Ticker Tapes Tracing Millions of Developing Cells

Enzyme Knockdown Repolarizes Immune Cells for Targeted Immunotherapy

Mitochondrial Genome Dynamics Influence Intrinsic Tumor Aggressiveness

Higher-Order Receptor Clustering Acts as Hidden Lymphangiogenic Signal Amplifier

USP15 Protein May Help Ovarian Cancer Resist Chemotherapy

Single-Cell Metabolic Profiling Identifies Key Bioenergetic Targets in Human Tumor Tissue

Targeted Y Chromosome Deletions Disrupt Key Cellular Immune Response Pathways

Oncogene-Induced Senescence Exhibits Dual Role in Tumor Suppression and Progression

Post-Translational Modification Crosstalk Regulates Oncogenic Protein Stability and Activity

Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

Chronic Inflammation Linked to Heart Changes and Risks

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Study Uncovers Two-Protein Repair Mechanism Preserving Circular ecDNA Stability

Mitochondrial RNA May Explain How Tumors Become Resistant to Immunotherapy

Tumor Suppressor Pathways Remain Intact but Hyperactive During Progressive Tissue Aging

Obesity May Remove a Natural Defense Against Breast Cancer

Researchers Reveal How p53 Tumor-Suppressor Protein Hide From T Cells

The Future of Vision Restoration With ReVision Implant

How a Single List Is Changing Visibility for Women in Science

How Avatar Medical's 3D Technology Is Transforming How We Visualize the Human Body

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