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Neutrophil Activation by NMU Blocks Cytotoxic T Cell Tumor Infiltration

A new study from The Wistar Institute has found a link between the nervous system and the rapid development of neuroendocrine prostate cancer (NEPC), an aggressive form of the disease.

26 Sep 2026

Chronic Inflammation Linked to Heart Changes and Risks

Chronic inflammation, indicated by GlycA levels, has been linked to heart changes and increased cardiovascular risk, highlighting genetic and environmental interactions.

25 Sep 2026

Cancer Cells Hijack Embryonic Repair Mechanisms to Seed Liver Metastases

Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.

25 Sep 2026

Cancer-Associated Fibroblasts Construct Physical Barriers Limiting Antitumor T Cell Infiltration

Researchers at The University of Texas MD Anderson Cancer Center have identified a previously unknown pathway that prostate tumors leverage to suppress the immune system by reshaping the tumor microenvironment to resist treatment.

25 Sep 2026

Study Uncovers Two-Protein Repair Mechanism Preserving Circular ecDNA Stability

Researchers at Memorial Sloan Kettering Cancer Center (MSK) and their colleagues have discovered that a type of rogue DNA found in aggressive cancers has a hidden structural weakness - and that blocking a single repair protein can cause it to fall apart, suggesting a new therapeutic opportunity.

24 Sep 2026

Mitochondrial RNA May Explain How Tumors Become Resistant to Immunotherapy

Research highlights mitochondrial RNA's influence on interferon signaling, linking chronic exposure to tumor growth and offering new avenues for immunotherapy.

22 Sep 2026

Tumor Suppressor Pathways Remain Intact but Hyperactive During Progressive Tissue Aging

A new review was published in Volume 18 of Aging on August 31, 2026, titled "The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework."

22 Sep 2026

Obesity May Remove a Natural Defense Against Breast Cancer

A research team at Huntsman Cancer Institute at the University of Utah (the U) has found that obesity prevents a biological process that kills cancerous cells, revealing a possible reason why obesity is a risk factor for breast cancer.

18 Sep 2026

Researchers Reveal How p53 Tumor-Suppressor Protein Hide From T Cells

One of the biggest challenges in cancer immunotherapy may not be that immune cells are too weak, but that some tumors give them too little to see.

18 Sep 2026

Uncovering B Cell Signaling Pathways to Enhance Targeted T Cell Immunotherapies

Cancer is the second leading cause of death in the United States, according to a 2026 Cancer Research Institute report. Cancer biologists are keenly aware of this statistic, as it drives them to innovations that revolutionize cancer care-innovations like immunotherapy.

17 Sep 2026

Study Uncovers Hidden Human "Dark Proteome" Members Across Protein Models

Hundreds of millions of proteins make up the known protein universe, but most remain largely unexplored. Inside the human body, thousands of these dark proteins remain mysteries. Scientists may know they exist, but not what they do or why they matter.

12 Sep 2026

New Insights Into How Giant-Nucleus Cells Promote Early-Stage Cancer Growth

Iron is an essential micronutrient, but excess iron can damage cells and increase cancer risk. While many cells die from iron-induced oxidative stress, a subset survives and may become cancerous. Previously, the identity of these surviving cells was unclear.

11 Sep 2026

Reprogramming Tumor Immune Microenvironment to Combat Aggressive Glioblastoma Brain Cancer

Mayo Clinic researchers have identified a potential new approach to treating glioblastoma that could help the immune system fight the aggressive brain cancer while improving the effectiveness of existing chemotherapy.

11 Sep 2026

Study Reveals Structural Roughness as Key Factor in Tumor Detachment Dynamics

In 2024, malignant tumors caused more than 21,300 deaths in Austria, 4.7% more than in 2014. Faced with a similarly pressing global challenge, scientists are striving to better understand what drives cancer cells to grow, spread, and invade healthy tissue.

10 Sep 2026

UCLA Breakthrough Generates Thousands of Allogeneic T-Cell Doses From Single Cord Blood Sample

T cell receptor, or TCR, therapy is a cancer treatment that genetically reprograms immune cells, called T cells, to hunt down cancer with precision.

9 Sep 2026

Advanced RNA Sequencing Separates Rare Regenerative Cells From Mature Tissue

Researchers at Weill Cornell Medicine and Hospital for Special Surgery have discovered the unspecialized stem cells that give rise to the body's tendons and ligaments, the tissues connecting muscles and bones.

8 Sep 2026

Research Maps Complex Molecular Rules Governing Specialized Tumor Immunity

For decades, natural killer (NK) cells have been classified into two main groups based on surface markers: one specialized for cytokine production and the other for direct killing.

7 Sep 2026

Study Reveals Hidden Mutational Process in Colorectal Cancer

The discovery of SBS111 in colorectal cancer offers new perspectives on mutational processes and DNA repair, emphasizing its significance in tumor biology.

3 Sep 2026

UNC Researcher Wins Mathers Foundation Grant to Study T-Cell Metabolism

Jessica Thaxton, PhD, MsCR, associate professor in the Department of Cell Biology and Physiology at the UNC School of Medicine and co-leader of the Cancer Cell Biology Research Program at UNC Lineberger Comprehensive Cancer Center, has been awarded a prestigious $700,000 grant from the Mathers Foundation to support research into the role of the endoplasmic reticulum in T-cell metabolism and cancer development.

2 Sep 2026

Super-Resolution DNA Imaging Platform Links Chromatin Loosening to Tumor Progression

Scientists have engineered fluorescent molecules enabling the visualization of DNA organization within living cells with unparalleled resolution, and in fixed cells, nearly the width of the double helix itself.

31 Aug 2026