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Bone-building hormone eases chronic low back pain by restoring vertebral microarchitecture

Parathyroid hormone shows promise in treating low back pain by remodeling degenerating vertebral endplates and limiting pathological sensory innervation.

12 Feb 2026

Single-cell atlas reveals how melanoma evades the immune system

Integrative analysis of immune ecotypes in skin cancers highlights metabolic reprogramming and macrophage polarization as key factors in melanoma progression.

11 Feb 2026

New Insights into TRiC and Prefoldin Mechanics

Proteins are the molecular machines of cells. They are manufactured in protein factories known as ribosomes using their blueprint, or genetic information.

6 Feb 2026

Why The Gut Helps Hypervirulent Bacteria Acquire Antibiotic Resistance

Study shows hypervirulent Klebsiella pneumoniae can acquire drug resistance in the gut, challenging traditional views on antibiotic resistance transmission.

4 Feb 2026

Gravity-Driven Microfluidic Platform Enhances Immune Cell-Tissue Co-Culture

Advanced in vitro models such as organ-on-chip systems aim to replicate human physiology more accurately than conventional cell cultures. However, most existing platforms struggle to incorporate circulating cells like immune cells or circulating tumor cells.

3 Feb 2026

Expanding the Biosynthetic Capabilities of Microbes Using Light

Researchers are continually looking for new ways to hack the cellular machinery of microbes like yeast and bacteria to make products that are useful for humans and society.

2 Feb 2026

Single Enzyme Enables Low-Cost Synthesis of All RNA Nucleotides

A single enzyme that can generate all four nucleotide triphosphates, the building blocks of ribonucleic acid (RNA), was identified by researchers at the Institute of Science Tokyo.

24 Jan 2026

Engineered Human Skin Acts as a Living Biosensor for Inflammation

Implanted living skin-based biosensors offer a breakthrough in inflammation tracking, providing real-time biomarker monitoring without invasive procedures.

21 Jan 2026

Turning Human Fat into Insulin-Producing Organoids That Reverse Diabetes

By preserving fat tissue architecture, researchers created organoids that restore insulin function, paving the way for advancements in diabetes treatment.

8 Jan 2026

New Method Turns Glial Cells Directly Into Parvalbumin Neurons

Parvalbumin cells play a central role in keeping brain activity in equilibrium. They control nervcell signaling, reduce overactivity and make sure that the brain is working to a rhythm.

5 Jan 2026

Engineered EVs Offer a Modular and Clinically Adaptable Immune-Tolerance Platform

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.

24 Dec 2025

New 3D Model Reveals Crucial Interactions During Early Embryo Development

By engineering a system replicating the womb lining with high biological accuracy, researchers at the Babraham Institute and Stanford University have been able to study the implantation of human embryos, opening up this enigmatic process to investigation.

24 Dec 2025

Simple Vibration Platform Enables Uniform Biomolecular Condensate Formation

A research group led by Professor Hiroaki SUZUKI and Takeshi HAYAKAWA from the Faculty of Science and Engineering at Chuo University, graduate student Zhitai HUANG, graduate students Kanji KANEKO (at the time) and Ryotaro YONEYAMA (at the time), together with Specially Appointed Assistant Professor Tomoya MARUYAMA from the Research Center for Autonomous Systems Materialogy (ASMat), Institute of Integrated Research (IIR), Institute of Science Tokyo, and Professor Masahiro TAKINOUE from the Laboratory for Chemistry and Life Science, Institute of Integrated Research, Institute of Science Tokyo, has developed a novel and highly accessible technology for producing uniform Biomolecular Condensates using a simple, low-cost vibration platform.

23 Dec 2025

Smart Hydrogel Senses Infected Wounds and Delivers the Right Treatment

The novel hydrogel adapts to wound environments, offering precise antibacterial and regenerative support, addressing the challenges of infected wounds.

18 Dec 2025

Essential Proteins May Have Evolved to Allow Misfolding Repair

Proteins need to fold into specific shapes to perform their functions in cells, but they occasionally misfold, which can prevent them from properly functioning and even lead to disease.

18 Dec 2025

Nearly 1/3 of Pesticides and Industrial Chemicals Harm Gut Bacteria

A study reveals that common pesticides and industrial chemicals inhibit gut bacteria, highlighting risks to health and the need for revised safety assessments.

5 Dec 2025

Circular Single-Stranded DNA Molecule Can Simultaneously Silence Multiple MicroRNAs

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen Dong of the Institute of Chemistry, Chinese Academy of Sciences, have collaborated to develop a circular single-stranded DNA molecule capable of simultaneously silencing multiple miRNAs.

4 Dec 2025

Light-Activated AR3 Triggers Alkalinity-Driven Apoptosis in Cancer Cells

One of the hallmarks of cancer cells is their ability to evade apoptosis, or programmed cell death, through changes in protein expression.

2 Dec 2025

Real-Time Visualization Reveals the Transcriptional Gearbox

Life's instructions are written in DNA, but it is the enzyme RNA polymerase II (Pol II) that reads the script, transcribing RNA in eukaryotic cells and eventually giving rise to proteins.

28 Nov 2025

UBQLN2 Liquid Droplets Found to Catalyze Early α-Synuclein Aggregation

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region of the brain, damaging these neurons and leading to the motor symptoms of the disease. α-synuclein (α-syn), a misfolded protein, aggregates and forms fibrils, which leads to the formation of LBs.

27 Nov 2025