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New Base Editing Strategy Rewrites Genetic Code to Minimize Huntington's Symptoms

A gene editing tool designed to precisely rewrite the gene that causes Huntington's disease reduced toxic protein fragments and symptoms associated with the disease in mice, researchers at the University of Illinois Urbana-Champaign report.

30 Jul 2026

Study Provides New Insights for the Development of Novel Antifungal Drug Targets

This study was conducted by the research group of Professor Liao Guojian from the College of Pharmaceutical Sciences, Southwest University. Candidate genes potentially involved in lysine synthesis in C. neoformans were identified and knocked out.

29 Jul 2026

Microneedle Patches Turn Skin Into a Window for Immune Bioanalysis

Researchers combined local restimulation of skin-resident memory T cells with hydrogel-coated microneedle patches to recruit and sample rare immune cells. In mouse models, the approach recovered more antigen-specific T cells than a blood sample or punch biopsy, while studies in humans supported short-term tolerability and proof-of-concept cell sampling.

28 Jul 2026

Wearable Microneedle Sensor Enables In Vivo Bioanalysis of Cardiac Biomarkers

Researchers developed a microneedle electrochemiluminescence device that measured cardiac troponins in interstitial fluid at 30-minute intervals and detected cTnI down to 21.3 fg/mL in artificial interstitial fluid. In 15 rats and 1 pig, researchers recorded biomarker trends broadly consistent with serum ELISA results, although the wired, single-target prototype has not been tested in humans.

28 Jul 2026

New Molecule Restores Muscle Repair Signal Linked to Age-Related Muscle Loss

One of the first tissues to deteriorate with aging is skeletal muscle. Weakness, scarring, internal muscle fat accumulation, and the loss of fast-twitch muscle fibers—which are crucial for rapid and forceful movements—can result from this deterioration.

27 Jul 2026

Antibody-Based Strategy Makes Stem Cell Transplants Safer

Stem cell transplantation (also called bone marrow transplantation) and gene therapy are among the most powerful curative approaches for blood diseases such as sickle cell disease, b-thalassemia, immune deficiencies, and some blood cancers.

9 Jul 2026

Optoelectronic Tweezers Revolutionize Live Cell Screening Without Causing Physical Damage

Single-cell research can reveal cellular heterogeneity, functional diversity, and disease-related mechanisms, making it an important foundation for precision diagnostics, drug development, and personalized therapy.

7 Jul 2026

Southern Medical University Uncovers Crucial Protein Linked to Lung Fibrosis

A study published recently in Current Molecular Pharmacology has uncovered a key mechanism linking aging to persistent pulmonary fibrosis, identifying the transcriptional regulator fPRDM16 as a potential therapeutic target.

26 Jun 2026

New Research Identifies Molecular Switch for Disfiguring Hypertrophic Skin Scars

A research team has uncovered a cellular and molecular mechanism that may help explain why some wounds develop into hypertrophic scars, the raised and often rigid scars that can cause itching, pain, disfigurement, and restricted movement.

26 Jun 2026

Cryo-EM Imaging Uncovers the Structure of a Mysterious Molecular "Gate"

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open questions in cell biology. Using cryo-electron microscopy (cryo‑EM), Leonid Sazanov and Ziyu Zhao at the Institute of Science and Technology Austria (ISTA) have now uncovered new details about a molecular "gate." Their findings were published in Molecular Cell.

23 Jun 2026

Decoding Hidden Metabolic Tissue Crosstalk via Advanced Proteomic Tracking

The body's organs are in constant communication. Fat tissue tells the liver when to store or release energy, the immune system signals localized inflammation, and thousands of proteins carry these messages to organs throughout the body.

23 Jun 2026

Researchers Study Chloroplast Antenna Proteins to Boost Global Crop Yields

Plants must carefully strike a balance between harvesting sunlight to fuel photosynthesis and protecting themselves from light damage.

17 Jun 2026

Molecular Cell Study Explains Gut Microbiome Impact on Liver Genes

A local research study led by scientists from the A*STAR Genome Institute of Singapore (A*STAR GIS) has uncovered how the gut microbiome can influence gene activity in the liver by acting on short stretches of regulatory DNA that function like molecular "switches".

16 Jun 2026

Antibody-Directed Xenophagy Pathway Blocks Intracellular Infections From Spreading

Scientists have revealed the process by which cells can internally digest bacteria and viruses.

5 Jun 2026

A New Non-Destructive Tool Maps Active Transcription Profiles in Living Tissue

Cell function is determined by how DNA is expressed into proteins. That process includes two main steps - transcription, when messenger RNA (mRNA) makes copies of active genes, and translation, when mRNA guides protein assembly.

2 Jun 2026

AI Designs Custom Miniproteins to Precisely Control Cell Receptors

G protein-coupled receptors, or GPCRs, sit in the plasma membrane, the boundary that defines the inside and outside of a living cell. They communicate with nearly every physiological process in our bodies - from the ability to see and smell, to sensing of adrenaline, insulin, nutrients and medicines.

22 May 2026

Copper-Free Click Reactions Allow Safe In Vivo Tracking of Tumors Inside the Body

Conventional cancer treatments like chemotherapy often struggle with poor targeting, leading to severe systemic toxicity and drug resistance. Diagnostic techniques, while improving, are frequently invasive and cannot monitor treatment responses in real time.

20 May 2026