Alzheimer's disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills and, eventually, the ability to carry out the simplest tasks of daily living. In most people with AD, symptoms first appear after age 60. AD is the most common cause of dementia among older people, but it is not a normal part of aging. Dementia refers to a decline in cognitive function that interferes with daily life and activities. AD starts in a region of the brain that affects recent memory, then gradually spreads to other parts of the brain. Although treatment can slow the progression of AD and help manage its symptoms in some people, currently there is no cure for this devastating disease.
A new priority research paper, featured as the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22, was published on December 29, 2024. The paper is titled "Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution."
Researchers with the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC) have unveiled a critical mechanism that links cellular stress in the brain to the progression of Alzheimer's disease (AD).
A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers at the University of Illinois Urbana-Champaign report.
In recent years, mice have entered a new arena – virtual reality – and now Cornell University researchers have built mini VR headsets to more fully immerse them.
Much like plants in a thriving forest, certain cells in the brain create a nurturing environment, enhancing the health and resilience of their neighbors, while others promote stress and damage, akin to a noxious weed in an ecosystem.
Microgravity exposure accelerates brain cell development in organoids, revealing potential implications for neurodegenerative disease research and space health.
In a provocative new study, scientists challenge a fundamental tenet in neuroscience about the shape of axons -- the long, thin filaments radiating from nerve cells that transmit electrical signals from cell to cell – and propose a new model for understanding how information is transmitted in the brain.
Why do adults make new brain cells? A new study published in Cell Stem Cell provides the first cellular evidence that making new brain cells in adults supports verbal learning and memory, which enables people to have conversations and to remember what they hear.
Millions of people worldwide suffer from Alzheimer's disease, a crippling illness that gradually robs people of their memory and cognitive abilities.
Beyond their use as fuel during fasting, the body's production of ketones plays a part in controlling cellular functions and aging processes.
In 1992, Judith Frydman, PhD, discovered a molecular complex with an essential purpose in all of our cells: folding proteins correctly.
An international group of researchers from FutureNeuro, the Research Ireland Centre for Translational Brain Science, and RCSI University of Medicine and Health Sciences have created a novel technique to characterize gene activity in the living human brain.
A study published in Nature by researchers at Baylor College of Medicine changes the way we understand memory.
Researchers at the University of Wisconsin–Madison are cautioning that the growing use of artificial intelligence techniques in genetics and medicine may result in incorrect inferences regarding the relationship between genes and physical traits, such as risk factors for diseases like diabetes.
In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.
Parkinson's disease (PD) and Alzheimer's disease (AD) are examples of brain illnesses that begin to develop in patients far earlier than the onset of their initial clinical symptoms.
Alzheimer's disease is characterized by a progressive loss of nerve cells leading to a decline in memory and cognition. A team of researchers at KU Leuven and VIB explored the molecular sequence of events in this cellular demise and identified specific inhibitors that could prevent the loss of nerve cells in different mouse models of the disease.
Using stem cells generated from patients with a rare and severe form of autism spectrum disorder and intellectual disability, Scripps Research scientists have grown personalized "mini-brains" (or organoids) to study the disorder in new detail.
A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies the process of protein synthesis and impacts RNA processing in Alzheimer's patients' brains.
Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze.
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