Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder. They now report that the effects of the therapy appear to be long-lasting, with 90% of patients who received the treatment eight to 11 years ago still disease-free.
More than 40,000 allogeneic hematopoietic stem cell transplants are carried out worldwide every year, mostly for patients suffering from leukemia or other diseases of the hematopoietic system.
Multi-institutional researchers have succeeded in efficiently delivering an immune checkpoint inhibitor (ICI) into the mouse brain, confirming its high efficacy and specificity in treating orthotopically transplanted mice with glioblastoma (GBM). The research was published in Nature Biomedical Engineering.
Mesenchymal stem cells (MSCs) are anticipated to harbor great potential in the area of regenerative medicine, which aims at restoring damaged tissues.
Research reveals how stem cells slow down their rolling inside the circulatory system by developing long tethers that bind to the inner surfaces of blood vessels.
Researchers carried out the first extensive investigation of the formation of the blood and immune systems in the prenatal bone marrow.
Opioids are a class of substances that control sensations such as pain and emotions in animals. While plant-derived opioid narcotics such as morphine are the most well-recognized, other opioid molecules like endorphins can also be synthesized by the body or artificially developed in laboratories.
Researchers elucidate why certain drugs, in clinical trials, for treating a kind of acute myeloid leukemia often fail and revealed a means to restore their efficacy.
The bones become thinner with age, resulting in frequent fractures and making them susceptible to bone diseases like osteoporosis.
A new Cornell study has found the antimicrobial properties of certain stem cell proteins could offer a potential treatment to reduce infection in skin wounds.
Stem cell transplants do not lead to changes in the DNA of the donor cells. That's according to a new study, which provides important evidence for the safety of this procedure.
New research published today in JAMA Oncology reports how two separate DNA changes appear to predict aggressive childhood leukemias when they occur in combination.
Hematopoietic stem cells — the precursors to blood cells — have been notoriously difficult to grow in a dish, a critical tool in basic research.
A team of researchers from the University of California - Davis Health (UC Davis) has made a breakthrough discovery of a unique type of stem cell that reduces the amount of the virus that causes AIDS.
Type 2 diabetes patients who are not overweight and who have had the disorder for less than a decade can benefit from stromal stem cells transplanted from their own bone marrow, according to a study published today in STEM CELLS Translational Medicine.
Researchers from the Wellcome Sanger Institute and the University of Cambridge discovered that in children with neuroblastoma—a tumor of immature nerve cells—platinum chemotherapy created mutations in the genome that might lead to leukemia in some children later on.
Your immune system is always busy fighting incoming threats. It consists of a system of cells, and when there is a shortage of cells, it affects the performance of the immune system.
The chemotherapy drug decitabine is commonly used to treat patients with blood cancers, but its response rate is somewhat low. Researchers have now identified why this is the case, opening the door to more personalized cancer therapies for those with these types of cancers, and perhaps further afield.
According to a new study, targeting a pathway that is critical for the survival of some cases of acute myeloid leukemia could open up a new therapeutic route for patients.
The human immune system comprises functionally specialized cellular defense mechanisms that protect the body against disease.