Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.
Researchers at Children's Hospital of Philadelphiahave developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant (HSCT).
The Stem Cell and Bone Marrow Transplant Program at Cedars-Sinai Cancer was recently recognized with two important hallmarks of quality: official accreditation for CAR T-cell therapy, and a third year in a row ranking among the top adult bone marrow transplant programs in the U.S.
In the regulation of hematopoietic stem cells—which are the immature stem cells that produce all the blood cell lineages—the cell protein retinoid X receptor (RXR) is an important element.
If the body’s emergency hematopoiesis program activates, it signifies an alert state of the immune system and serves two functions: In comparison to “normal mode” hematopoiesis, the emergency program results in enhanced replacement of immune cells consumed during infections or inflammations.
CAR T cells, or engineered immune cells, have demonstrated to the world the potential of customized immunotherapies to treat blood cancers. Researchers have just released highly encouraging preliminary data for CAR T therapy in a small group of lupus patients.
Lab tests on astronaut Scott Kelly’s blood cells after he returned from a year-long stay aboard the International Space Station (ISS) showed telomeric and pre-leukemic changes.
A new cell-intrinsic mechanism has been unraveled by scientists at the University of Basel. This regulates the correct number of T cells present in the organism and thus guarantees that the immune system functions in a proper manner.
Vaccines function by effectively producing immune cells that live for a long time, frequently for decades. These immune cells form a protective barrier that prevents or reduces re-infection, as well as a memory that enables one to identify an old invader, such as a virus, and eliminate it before it causes disease.
A fault in cells that form a key part of the immune system can be repaired with a pioneering gene editing technique, finds new research demonstrated in human cells and mice, led by UCL scientists.
The genes that are activated in a single cell can now be determined thanks to advances in high-throughput biological studies. However, interpreting the resulting complex datasets might be difficult.
According to a recent study conducted by scientists at Emory University in Atlanta, the administration of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive type of skin cancer, expedited their metastatic bone growth.
Researchers at Johns Hopkins Medicine claim to have discovered significant molecular variations between cancer cells that adhere to an initial tumor and those that spread out to develop distant tumors while researching the fatal form of breast cancer known as triple negative.
Researchers have developed a unique 3D printed system for harvesting stem cells from bioreactors, offering the potential for high quality, wide-scale production of stem cells in Australia at a lower cost.
Ophthalmologists and researchers have been looking into mesenchymal stem cells (MSCs) with regenerative and differentiation capacities as a potential therapy option for corneal disorders.
Hypomethylating agents (HMA) are currently used as a first-line treatment for patients with myelodysplastic syndrome (MDS) - a group of disorders where there is insufficient production of healthy mature blood cells in the bone marrow - and increasingly in other diseases, but their mechanism of action remains unclear.
Small interfering RNAs, or siRNAs, have the potential to cure tumors by targeting knocking down oncogenes that drive tumor development while avoiding the damage associated with chemotherapy.
Glioblastomas (GBMs) are cancerous tumors of the brain and spinal cord that are incredibly aggressive.
Researchers from Tokyo University of Agriculture and Technology have made a novel revelation about the processes of bone loss in gum disease (periodontitis).
A finding by UC Riverside bioengineers could hasten development of lab-grown blood vessels and other tissues to replace and regenerate damaged tissues in human patients.
The mystery is being unraveled of why the control centers, or nuclei, of certain blood cancer cells have a distinctly odd shape.