Carcinogenesis News and Research

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Protein RAD51 Acts as Guardian Against DNA Over-Replication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent.

5 Mar 2024

Epimutations in BRCA1 Gene Linked to Triple-Negative Breast Cancer

Research reveals that around 20 per cent of all cases of the most severe form of breast cancer may arise from the small group of normal tissue cells carrying an epimutation of a specific gene.

8 Dec 2023

Study Identifies Risk Genes and Regulatory Variants for Colorectal Cancer by Integrating Multi-Omics Data

This study was led by Prof. Xiao-Ping Miao' team from the School of Public Health, Wuhan University, in collaboration with Prof. Shaokai Zhang from the Henan Cancer Hospital.

2 Nov 2023

New Protein Found to be Key to Proper Functioning of Acinar Cells

The energy supply in the body has been regulated by the pancreas, located behind the stomach. This mechanism happens by secreting proteins (enzymes) accountable for glucose–the body’s primary fuel–reaching other organs when needed and in the exact amount.

24 Jul 2023

Understanding the Process of Gene Regulation Using Cryogenic Electron Microscopy

LMU researchers show detailed displacement process of TBP transcription factor from DNA by Mot1 enzyme.

2 May 2023

Monitoring bovine meat and milk factor protein expression could enable colorectal cancer detection

Bovine meat and milk factors (BMMFs)-; initially identified by de Villiers et al. in 2014-; represent a class of infectious agents in beef and cow's milk that have been linked to the development of cancer.

23 Feb 2023

Accumulation of collagen at injured sites in the gut stimulates cellular reprogramming, study reveals

Most cells have a pretty normal life: they're born, they grow, they get old, and they die. But the Benjamin Buttons of the cellular world can go from old to young again in the right context.

30 Jan 2023

New method for generating metabolic profiles of individual cells

Researchers from the EMBL and the German Cancer Research Center (DKFZ) demonstrated a new technique to create metabolic profiles of individual cells.

8 Jul 2021

Exploring the Genetic effects of Chernobyl Radiation

In this interview, AZoLifeSciences speaks to researchers from the National Cancer Institute about their latest research that investigated the genetic effects of Chernobyl radiation.

From National Cancer Institute (NCI) 13 May 2021

Study shows how nonmalignant cells adapt to harsh tumor microenvironment

Cells need energy to survive and thrive. Generally, if oxygen is available, cells will oxidize glucose to carbon dioxide, which is very efficient, much like burning gasoline in your car. However, even in the presence of adequate oxygen, many malignant cells choose instead to ferment glucose to lactic acid, which is a much less efficient process.

20 Jan 2021

Scientists use new technology to observe DNA defects in children with Fanconi anemia

Scientists have successfully utilized a novel stem cell technology to examine the skin, specific to a group of living patients, in laboratory settings.

24 Nov 2020

New data shows immunotherapy is beneficial for patients with gastric, esophageal cancers

New data presented at ESMO 2020 have shown that immunotherapy is beneficial for patients with gastric and esophageal cancers who currently have poor survival. (1-3)

24 Sep 2020

Increased blood lead levels in children are linked to reduced expression of genes

Researchers have revealed a connection between methylation of genes implicated in heme synthesis and carcinogenesis and high blood lead levels in children, signifying a previously unfamiliar mechanism for lead poisoning.

10 Aug 2020

Organoids reveal inflammatory processes that play a role in infectious diseases

Research is employing mini-organs to model the digestive tract in the laboratory setting. These supposed organoids shed light on the inflammatory processes.

6 Jul 2020

Researchers discover a mechanical cause for cell extrusion

In the human body, the inner or outer boundaries of organs are lined with the supposed epithelial sheets.

22 Jun 2020

Scientists Recreate DNA Damage Caused By Toxins From Smoking

Researchers from the University of York have recreated how toxins from smoking cause unique patterns of DNA damage.

29 Apr 2020

Amperometric Sensors Assist In Analyzing Food Safety

Antioxidants are one of the most widely investigated compounds due to their role in protecting living systems from the negative effects of free radicals.

24 Apr 2020

A Cellular Mechanism Protecting Against Cancer

Researchers at the University of Bayreuth have discovered a natural protective mechanism that leads to the programmed death of potentially diseased cells.