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Machine Learning Accelerates Personalized T Cell Therapy Development for Cancer Patients

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

18 Mar 2024

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment At the RIKEN Center for Integrative Medical Sciences in Japan, researchers under the direction of Hiroshi Ohno have found a connection between gut microbiota and the effectiveness of oral immunotherapy for milk allergies.

15 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Machine Learning Reveals Cancer-Causing DNA Repeats

It has been difficult to identify and characterize repeats of DNA sequences, also known as “junk DNA” or “dark matter,” that are found in chromosomes and may be involved in cancer or other diseases.

14 Mar 2024

Dual-Target CAR T Cell Therapy Shows Promise Against Recurrent Glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

14 Mar 2024

Study Reveals Unique Bacterial Fingerprints and Their Impact on Health

The trillions of bacteria that call your body home -; collectively known as the microbiome -; appear to be unique to you, like a fingerprint.

13 Mar 2024

NIH Researchers Map Vulnerable Sites on Epstein-Barr Virus gp42 Protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

13 Mar 2024

AI Research Gives Unprecedented Insight Into Heart Genetics and Structure

A ground-breaking research study has used AI to understand the genetic underpinning of the heart’s left ventricle, using three-dimensional images of the organ.

12 Mar 2024

Reducing Iron May Reverse Stem Cell Aging

It is fascinating to learn how researchers at the Albert Einstein College of Medicine and the National Cancer Institute-designated Montefiore Einstein Comprehensive Cancer Center (MECCC) have discovered a way to prevent or even reverse the function of hematopoietic (blood-forming) stem cells (HSCs) as they age.

11 Mar 2024

Transition to Laser-Based 3D Bioprinting: Stride Towards Addressing Organ Shortage

Recent advancements in laser technology are leading to groundbreaking developments in the medical field, from improved treatment of cardiovascular diseases to higher-precision manufacturing of medical devices.

7 Mar 2024

‘Like a PCR Lab in Your Pocket': New Test Strips Raise Game in Gene-Based Diagnostics

Biosensing technology developed by UNSW engineers has made it possible to make portable RAT tests just as accurate as PCR tests carried out in a lab.

7 Mar 2024

Quantifying Strain Variability in Natural Bacterial Populations

Researchers led by Kostas Konstantinidis from the Georgia Institute of Technology developed a novel approach to categorize bacteria into distinct species and strains, addressing a long-standing challenge in microbiology.

5 Mar 2024

Unlocking the Potential of Microbiome-Based Cancer Therapies

The microbiome can identify patients with rare gynecological cancers, biliary tract cancers, and melanoma who will benefit from combination immunotherapy for various cancer types.

4 Mar 2024

Scientists Discover Dual Challenges in DNA Replication Process

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied.

29 Feb 2024

New "Tissue-in-a-CUBE" Offers Alternative to Animal Testing in Drug Development

A research team at the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan has succeeded in establishing a model of the blood-brain barrier using modularized tissue derived from human cells.

29 Feb 2024

Genetic Mechanisms of Alzheimer's Revealed in Colombian Kindred

UC Santa Barbara researchers and collaborators in Colombia, Brazil and Germany are progressing toward an understanding of mechanisms that underlie Alzheimer's disease, in particular an early-onset, genetic form that has afflicted generations of an extended family in Colombia.

28 Feb 2024

Study Provides Insights Into Molecular Mechanisms Underlying Healthy Aging in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, "The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut."

28 Feb 2024

Tandem Repeat Expansions Linked to Cardiomyopathy Risk, Reveals Study

In the first study to use whole genome sequencing to examine tandem repeat expansions in heart conditions, scientists at The Hospital for Sick Children (SickKids) have laid the groundwork for early detection of and future precision therapies for cardiomyopathy.

28 Feb 2024

Scientists Develop First Full Model of Early Human Central Nervous System with Stem Cells

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of Michigan, the Weizmann Institute of Science, and the University of Pennsylvania.

27 Feb 2024

Gut Microbial Metabolite Linked to Increased Thrombosis Risk in COVID-19 Patients

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.

26 Feb 2024